Results 1 to 10 of about 26,160 (305)

The Versatile Gasdermin Family: Their Function and Roles in Diseases

Frontiers in Immunology, 2021
The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except ...
Yi-Xiang Zheng, Yan Huang, Daolin Tang
exaly   +3 more sources

The gasdermin family: emerging therapeutic targets in diseases

Signal Transduction and Targeted Therapy
The gasdermin (GSDM) family has garnered significant attention for its pivotal role in immunity and disease as a key player in pyroptosis. This recently characterized class of pore-forming effector proteins is pivotal in orchestrating processes such as ...
Sheng Xu
exaly   +2 more sources

The Role of Pyroptosis in Colorectal Cancer: From Mechanisms to Therapeutic Opportunities [PDF]

Cancer Management and Research
Haiqing Xie, Xueting Deng, Quanpeng Li Medical Center for Digestive Diseases, Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Quanpeng Li, Medical Center for Digestive Diseases, Second ...
Xie H, Deng X, Li Q
doaj   +2 more sources

Pore-forming activity and structural autoinhibition of the gasdermin family

Nature, 2016
Jingjin Ding, Wang Liu, Jianjin Shi
exaly   +2 more sources

Gasdermin D: A potential mediator and prognostic marker of bladder cancer

Frontiers in Molecular Biosciences, 2022
Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal, Randa El-Gamal, Mona Abdelrahim, Mohamed El-Sherbiny, Eman T. Enan, Mohammad El-Nablaway, Mohammad El-Nablaway   +6 more
doaj   +1 more source

Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy

Frontiers in Pharmacology, 2021
Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in the plasma membrane, and cells swell, rupture, and then release their contents, including inflammatory cytokines.
Wen Li, Jing Sun, Xiaoxi Zhou, Yue Lu, Wenpeng Cui, Lining Miao   +5 more
doaj   +1 more source

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

BMC Biology, 2022
Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra, Cristina Alarcón-Vila, Laura Hurtado-Navarro, María C. Baños, Jack Rivers-Auty, Pablo Pelegrín   +5 more
doaj   +1 more source

Methods for monitoring cancer cell pyroptosis

Cancer Biology & Medicine, 2022
Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response.
Shuo Wang, Yuantong Liu, Lu Zhang, Zhijun Sun   +3 more
doaj   +1 more source

Role of pyroptosis in the pathogenesis and treatment of diseases

MedComm, 2023
Programmed cell death (PCD) is regarded as a pathological form of cell death with an intracellular program mediated, which plays a pivotal role in maintaining homeostasis and embryonic development.
Xiangyu Jin, Yinchu Ma, Didi Liu, Yi Huang   +3 more
doaj   +1 more source

Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism

Cells, 2022
With global ageing, sarcopenia, as an age-related disease, has brought a heavy burden to individuals and society. Increasing attention has been given to further exploring the morbidity mechanism and intervention measures for sarcopenia.
Hongfu Jin, Wenqing Xie, Miao He, Hengzhen Li, Wenfeng Xiao, Yusheng Li   +5 more
doaj   +1 more source