Results 1 to 10 of about 24,180 (354)

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

Nature Cell Biology, 2020
Although pyroptosis is critical for macrophages against pathogen infection, its role and mechanism in cancer cells remains unclear. PD-L1 has been detected in the nucleus, with unknown function.
Jung-Mao Hsu, Wei-Jan Wang, Yun Wu
exaly   +4 more sources

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation [PDF]

Nature Communications, 2019
Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane.
Dan A Erkes, Andrew E Aplin, Emad S Alnemri   +2 more
exaly   +4 more sources

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Science Immunology, 2020
GSDME-mediated target cell pyroptosis by CAR T cells activates macrophages to release proinflammatory cytokines for CRS. Gasdermin E as troublemaker Cytokine release syndrome (CRS) is a complication associated with chimeric antigen receptor (CAR) T cell ...
Yuying Liu, Yiliang Fang, Xinfeng Chen
exaly   +3 more sources

Vastly different energy landscapes of the membrane insertions of monomeric gasdermin D and A3 [PDF]

Communications Chemistry
Gasdermin D and gasdermin A3 belong to the same family of pore-forming proteins and executors of pyroptosis, a form of programmed cell death. To unveil the process of their pore formation, we examine the energy landscapes upon insertion of the gasdermin ...
Viktoria Korn, Kristyna Pluhackova
doaj   +2 more sources

Gasdermins in Innate Host Defense Against Entamoeba histolytica and Other Protozoan Parasites [PDF]

Frontiers in Immunology, 2022
Gasdermins (GSDMs) are a group of proteins that are cleaved by inflammatory caspases to induce pore formation in the plasma membrane to cause membrane permeabilization and lytic cell death or pyroptosis.
Shanshan Wang, France Moreau, Kris Chadee   +2 more
doaj   +2 more sources

Cryo-EM structure of the gasdermin A3 membrane pore [PDF]

Nature, 2018
Jianbin Ruan, Shiyu Xia, Xing Liu
exaly   +2 more sources

Gasdermin D: A potential mediator and prognostic marker of bladder cancer

Frontiers in Molecular Biosciences, 2022
Background: Bladder cancer is considered one of the commonest widespread cancers, its presentation ranges from non-muscle invasive form to being muscle-invasive. The gasdermin family of proteins consists of six proteins.
Randa El-Gamal, Randa El-Gamal, Mona Abdelrahim, Mohamed El-Sherbiny, Eman T. Enan, Mohammad El-Nablaway, Mohammad El-Nablaway   +6 more
doaj   +1 more source

Evolutionary analyses of the gasdermin family suggest conserved roles in infection response despite loss of pore-forming functionality

BMC Biology, 2022
Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines.
Diego Angosto-Bazarra, Cristina Alarcón-Vila, Laura Hurtado-Navarro, María C. Baños, Jack Rivers-Auty, Pablo Pelegrín   +5 more
doaj   +1 more source

Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy

Frontiers in Pharmacology, 2021
Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in the plasma membrane, and cells swell, rupture, and then release their contents, including inflammatory cytokines.
Wen Li, Jing Sun, Xiaoxi Zhou, Yue Lu, Wenpeng Cui, Lining Miao   +5 more
doaj   +1 more source

Methods for monitoring cancer cell pyroptosis

Cancer Biology & Medicine, 2022
Pyroptosis is a form of proinflammatory cell death that depends on the gasdermin family of proteins. The main features of pyroptosis are altered membrane permeability, cell swelling, membrane rupture, and the ability to mobilize a strong immune response.
Shuo Wang, Yuantong Liu, Lu Zhang, Zhijun Sun   +3 more
doaj   +1 more source