Results 111 to 120 of about 22,095 (292)
Phytotherapy Research, EarlyView.ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte +3 more
wiley +1 more source
Monitoring gasdermin pore formation in vitro
, 2019 The gasdermin (GSDM) family consists of gasdermin A (GSDMA), B (GSDMB), C (GSDMC), D (GSDMD), E or DNFA5 (GSDME), and DFNB59 in human. Expressed in the skin, gastrointestinal tract, and various immune cells, GSDMs mediate homeostasis and inflammation upon activation by caspases and unknown proteases.
Shiyu, Xia, Jianbin, Ruan, Hao, Wu
openaire +3 more sources
Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies
Sensory Neuroscience, EarlyView.ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao +6 more
wiley +1 more source
Exploring the role of pyroptosis in the pathogenicity of heart disease
Frontiers in PhysiologyCell death is an essential cellular mechanism that ensures quality control and whole-body homeostasis. Various modes of cell death have been studied and detailed.
Rohail Bhatti, Priscila Y. Sato
doaj +1 more source
Genetic risk factors for the development of allergic disease identified by genome-wide association [PDF]
, 2014 An increasing proportion of the worldwide population is affected by allergic diseases such as allergic rhinitis (AR), atopic dermatitis (AD) and allergic asthma and improved treatment options are needed particularly for severe, refractory disease ...
Hodge, Emily +2 more
core +3 more sources
VIEW, EarlyView.Areca nut extract (ANE), commonly consumed in some cultures, can damage gut cells by triggering inflammation and cell death through a pathway called cGAS‐STING. This leads to the release of harmful inflammatory substances and weakens the gut barrier. Our study shows that resveratrol, a natural compound found in foods like grapes, can block this harmful
Jing Zhang +4 more
wiley +1 more source
Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids [PDF]
, 2019 Current clinical diagnosis is typically based on a combination of approaches including clinical examination of the patient, clinical experience, physiologic and/or genetic parameters, high-tech diagnostic medical imaging, and an extended list of ...
Hoste, Eric, Vanden Berghe, Tom
core +2 more sources
The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li +4 more
wiley +1 more source
Microbiology and Immunology, EarlyView.ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen +9 more
wiley +1 more source
Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells [PDF]
, 2017 Introduction: The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases.
Cypryk, Wojciech +3 more
core +1 more source