Results 111 to 120 of about 24,180 (354)
Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]
, 2017 International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu +10 more
core +3 more sources
Succination inactivates gasdermin D and blocks pyroptosis
Science, 2020 Fumarate targets pyroptosis A form of inflammatory cell death called pyroptosis depends on the caspase-mediated cleavage of gasdermin D (GSDMD), the fragments of which assemble into permeability pores that then kill the cell.
Fiachra Humphries +16 more
semanticscholar +1 more source
Advanced Science, EarlyView.Although Zinc(II) complexes are effective in photodynamic therapy, their efficacy is limited by the poor tissue penetration of light. This work introduces a novel zinc(II) complex for sonodynamic therapy. Under ultrasound activation, it generates substantial singlet oxygen, induces pyroptosis in breast cancer cells, and promotes anti‐tumor immune ...
Sijie Wen +8 more
wiley +1 more source
Triggering Pyroptosis in Cancer
BiomoleculesPyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of cell death, canonical pyroptosis involves the specific cleavage of gasdermin by caspase-1,
Daniel E. Johnson, Zhibin Cui
doaj +1 more source
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. [PDF]
, 2011 Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including ...
Abel, Rebekah A +81 more
core +2 more sources
Nature CommunicationsImmune checkpoint inhibitor (ICI)-induced myocarditis involves intensive immune/inflammation activation; however, its molecular basis is unclear.
Si-Jia Sun +17 more
semanticscholar +1 more source
Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles
Advanced Science, EarlyView.A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu +13 more
wiley +1 more source
The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. [PDF]
, 2016 Published onlineJournal ArticleResearch Support, Non-U.S. Gov'tBACKGROUND: Many genetic variants have been associated with susceptibility to complex traits by genome wide association studies (GWAS), but for most, causal genes and mechanisms of action ...
Frayling, Timothy M. +7 more
core +1 more source
Nature CommunicationsInfluenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during infection ...
Samuel Speaks +17 more
semanticscholar +1 more source
Advanced Science, EarlyView.This study proposes for the first time that hepatic GSDMD plays a key protective role in sepsis. Hepatic GSDMD may release inflammatory inhibitory factors including VEGF‐B and Gremlin‐1 through pore‐forming activity to inhibit the production of inflammatory factors from macrophages, thereby alleviating the inflammatory response of septic mice ...
Yihan Qian +9 more
wiley +1 more source