Results 11 to 20 of about 22,095 (292)
Sublytic gasdermin-D pores captured in atomistic molecular simulations [PDF]
eLife, 2022 Gasdermin-D (GSDMD) is the ultimate effector of pyroptosis, a form of programmed cell death associated with pathogen invasion and inflammation. After proteolytic cleavage by caspases, the GSDMD N-terminal domain (GSDMDNT) assembles on the inner leaflet ...
Stefan L Schaefer, Gerhard Hummer
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Frontiers in Immunology, 2023 Sepsis is a hyper-heterogeneous syndrome in which the systemic inflammatory response persists throughout the course of the disease and the inflammatory and immune responses are dynamically altered at different pathogenic stages.
Wenhua Wang, Zhihui He, Zhihui He
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Scientific ReportsGasdermin C is one of the least studied members of the gasdermin family of proteins, known for their critical involvement in pyroptosis and host defense.
Reyes Gámez-Belmonte +13 more
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Pyroptosis, inflammasome, and gasdermins in tumor immunity
Innate Immunity, 2023 The gasdermins (GSDM), a family of pore-forming proteins, consist of gasdermin A (GSDMA), gasdermin B (GSDMB), gasdermin C (GSDMC), gasdermin D (GSDMD), gasdermin E (GSDME) and DFNB59 (Pejvakin (PJVK)) in humans.
Xiaohu Ouyang +5 more
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Gasdermins: novel mitochondrial pore-forming proteins [PDF]
Molecular & Cellular Oncology, 2019 Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described.
Corey Rogers, Emad S. Alnemri
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Gasdermins: the hole picture emerges [PDF]
Nature Reviews Immunology, 2016 Yvonne Bordon
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Gasdermin D and Beyond – Gasdermin-mediated Pyroptosis in Bacterial Infections
Journal of Molecular Biology, 2022 The discovery of pyroptosis and its subsequent implications in infection and immunity has uncovered a new angle of host-defence against pathogen assault. At its most simple, gasdermin-mediated pyroptosis in bacterial infection would be expected to remove pathogens from the relative safety of the cytosol or pathogen containing vacuole/phagosome whilst ...
Lee M, Booty, Clare E, Bryant
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Acta Pharmaceutica Sinica B, 2021 Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to induce strong inflammatory responses that defend the host against microbe infection. Excessive pyroptosis, however, leads to several inflammatory diseases, including sepsis and autoimmune disorders. Pyroptosis can be canonical or noncanonical.
Brandon E. Burdette +3 more
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Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors
eLife, 2022 The type VI secretion system (T6SS) is used by bacteria to deliver toxic effectors directly into target cells. Most T6SSs mediate antibacterial activities, whereas the potential anti-eukaryotic role of T6SS remains understudied.
Hadar Cohen +5 more
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Pyroptosis: Role and Mechanisms in Cardiovascular Disease
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular disease (CVD) is a common disease that poses a huge threat to human health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative capacity under stressful conditions, ultimately leading to impaired cardiac ...
Xinzhe Chen +4 more
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