Results 231 to 240 of about 24,180 (354)

Xiaoxianxiong Decoction Attenuates LPS‐Induced Pneumonia in Mice by Inhibiting Inflammatory Response Through Activation of SIRT1

FASEB BioAdvances, Volume 7, Issue 10, October 2025.
In the present study, through a series of in vivo and vitro experiments, we have demonstrated that XXXD ameliorates pneumonia by suppressing the inflammatory response through activation of SIRT1. This discovery provides experimental evidence for the mechanism of action of traditional Chinese medicine in treating pneumonia and also offers a fresh ...
Linfeng Shi, Jiayan Zhang, Yuntao Cai, Junyun Bao, Huichao Chen   +4 more
wiley   +1 more source

Dexmedetomidine Inhibits Gasdermin D-Induced Pyroptosis via the PI3K/AKT/GSK3β Pathway to Attenuate Neuroinflammation in Early Brain Injury After Subarachnoid Hemorrhage in Rats [PDF]

, 2022
Boyang Wei, Wenchao Liu, Lei Jin, Shenquan Guo, Haiyan Fan, Fa Jin, Chengcong Wei, Dazhao Fang, Xin Zhang, Shixing Su, Chuanzhi Duan, Xifeng Li   +11 more
openalex   +1 more source

Dysregulation of Different Modes of Programmed Cell Death in Rheumatoid Arthritis Fibroblast‐Like Synoviocyte

International Journal of Rheumatic Diseases, Volume 28, Issue 10, October 2025.
ABSTRACT Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by chronic synovitis and skeletal joint deformities, often accompanied by systemic symptoms. Over the past few decades, various susceptibility factors for RA have been revealed, and numerous therapeutic drugs have been developed, including analgesics, glucocorticoids ...
Xiaorong Zhi, Hong Zhu, Xiaoyan Sun, Zhaoxia Wang, Lin Wang, Guanhua Song   +5 more
wiley   +1 more source

Gasdermin-Mediated Pyroptosis in Hidradenitis Suppurativa: Molecular Insights and Therapeutic Implications. [PDF]

Biology (Basel)
Tyczyńska K, Krajewski PK, Sójka A, Nowicka-Suszko D, Bednarz-Misa I, Fleszar M, Krzystek-Korpacka M, Szepietowski JC.   +7 more
europepmc   +1 more source

A new lead to NLRP3 inhibition [PDF]

, 2017
Dixit, Vishva M, Lamkanfi, Mohamed
core   +2 more sources

Long non‑coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation‑induced pyroptosis via microRNA‑448/gasdermin E in colorectal cancer cells

, 2021
Fei Su, Junzhao Duan, Jie Zhu, Hanjiang Fu, Xiaofei Zheng, Chang‐Hui Ge   +5 more
openalex   +2 more sources

The gasdermin protein family: emerging roles in gastrointestinal health and disease

Nature reviews: Gastroenterology & hepatology, 2023
G. Privitera, N. Rana, A. Armuzzi, T. Pizarro   +3 more
semanticscholar   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Improved structure of mouse gasdermin D: a new blueprint for structure-based drug design. [PDF]

Acta Crystallogr F Struct Biol Commun
De Colibus L, Ludzia P, Biasutto A, Pica A, Hopper JTS, Jazayeri A, Dürr KL.   +6 more
europepmc   +1 more source

Downregulating Gasdermin D Reduces Severe Acute Pancreatitis Associated with Pyroptosis

, 2020
Tianjiao Lin, Jingyu Song, Xinting Pan, Youdong Wan, Ziqian Wu, Shaoyan Lv, Liangyu Mi, Yunyun Wang, Fei Tian   +8 more
openalex   +2 more sources