Results 251 to 260 of about 24,180 (354)

Zerumbone Attenuates Lipopolysaccharide‐Induced Acute Lung Injury by Suppressing the NLRP3/Caspase‐1/GSDMD Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 29, Issue 19, October 2025.
ABSTRACT A cyclic sesquiterpene with 11 carbon atoms is the primary component of essential oils from the wild ginger species, Zingiber zerumbet. It exhibits pharmacological effects, including anti‐inflammatory and antioxidant properties. However, limited information exists regarding its role in pyroptosis during acute lung injury (ALI).
Yun‐Jie Xu, Fei‐Fei Fang, Guo‐Qiang Zhao, Wei‐Yan Yu, Hong‐Yan Han, Hong Teng, Jun‐Ning Lyu, Jian‐Feng Wang   +7 more
wiley   +1 more source

Pyroptosis in cardiovascular diseases: roles, mechanisms, and clinical implications. [PDF]

Front Cardiovasc Med
Niu Y, Wang L, Zhang Y, Zou Y, Zhou C.
europepmc   +1 more source

O‐GlcNAcylation Mediated by OGA Activates NEK7/NLRP3 Pathway to Promote Pyroptosis in Parkinson's Disease

Journal of Cellular and Molecular Medicine, Volume 29, Issue 19, October 2025.
ABSTRACT Parkinson's disease (PD) is a neurodegenerative disorder characterised by pyroptosis. O‐GlcNAcylation, regulated solely by O‐GlcNAc transferase (OGT) and O‐GlcNAcase (OGA), has been shown to mitigate PD. This study aimed to investigate whether pyroptosis and PD pathogenesis are modulated by O‐GlcNAcylation.
Zhi Wang, Yue Liu, Lili Ma, Hongwei Sun, Ying Tang   +4 more
wiley   +1 more source

Gasdermin D: A New Inflammatory Biomarker in Assessing Clinical Disease Activity in Crohn's Disease. [PDF]

Turk J Gastroenterol
Buldukoglu OC, Ocal S, Atar GE, Kaya B, Isik MD, Aydin Tigli G, Akca S, Harmandar FA, Cekin Y, Cekin AH.   +9 more
europepmc   +1 more source

The Flavonoid Kaempferol Mitigates Periprosthetic Osteolysis by Regulating the NLRP3 Inflammasome and Balancing Bone Metabolism

Journal of Cellular and Molecular Medicine, Volume 29, Issue 19, October 2025.
ABSTRACT Total joint arthroplasty (TJA) is an effective intervention for end‐stage arthritis; however, its long‐term success is often compromised by wear particle–induced osteolysis, leading to aseptic loosening and implant failure. This study investigates the potential of kaempferol (Ka), a natural flavonoid with anti‐inflammatory properties, to ...
Cheng Huang, Chenhui Zhang, Yongjun Luo, Lujun Guo, Yanglin Wu, Qingyan Shi, Yazhong Zhang, Chengyuan Yang, Bo Wang, Junjie Niu, Jun Lin   +10 more
wiley   +1 more source

Metformin Attenuates Myocardial Ischemia-Reperfusion Injury in Rats by Modulating JNK Pathway and Inhibiting PANoptosis Mechanisms. [PDF]

Cardiovasc Ther
Hou B, Hou X, Zhang L, Liu T, Li Y, Dong R.   +5 more
europepmc   +1 more source

Nanosonodynamic effect-promoted mitochondrial dysfunction augments calcium overload for Gasdermin E-induced pyroptotic antitumor therapy

, 2022
Zheng Zhang, Xin Zhang, Shuangshuang Zhao, Caihong Dong, Wei Feng, Luodan Yu, Li Ding, Yu Chen, Baoding Chen   +8 more
openalex   +2 more sources

Mechanosensor Piezo1‑mediated smooth muscular cell pyroptosis contributes to vascular calcification. [PDF]

Int J Mol Med
Tao J, You D, Feng Z, Li H, Zhang Y, Cui Y, Lin K, Luo B, Yin S, Tan H.   +9 more
europepmc   +1 more source

A novel inflammatory biomarker in assessing disease activity in ulcerative colitis: gasdermin D. [PDF]

BMC Gastroenterol
Buldukoglu OC, Ocal S, Akca S, Atar GE, Kaya B, Isik MD, Koca O, Harmandar FA, Cekin Y, Cekin AH.   +9 more
europepmc   +1 more source

Human Gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signaling in budding yeast

, 2022
Marta Valenti, Marı́a Molina, Vı́ctor J. Cid   +2 more
openalex   +1 more source