Results 21 to 30 of about 24,180 (354)
Role of pyroptosis in the pathogenesis and treatment of diseases
MedComm, 2023 Programmed cell death (PCD) is regarded as a pathological form of cell death with an intracellular program mediated, which plays a pivotal role in maintaining homeostasis and embryonic development.
Xiangyu Jin +3 more
doaj +1 more source
Pyroptosis and Sarcopenia: Frontier Perspective of Disease Mechanism
Cells, 2022 With global ageing, sarcopenia, as an age-related disease, has brought a heavy burden to individuals and society. Increasing attention has been given to further exploring the morbidity mechanism and intervention measures for sarcopenia.
Hongfu Jin +5 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundDuchenne muscular dystrophy (DMD) is the most common inherited human myopathy. Typically, the secondary process involving severe inflammation and necrosis exacerbate disease progression.
Nicolas Dubuisson +9 more
doaj +1 more source
Gasdermins: Effectors of Pyroptosis [PDF]
Trends in Cell Biology, 2017 Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD).
Stephen B. Kovacs, Edward A. Miao
openaire +3 more sources
Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors
eLife, 2022 The type VI secretion system (T6SS) is used by bacteria to deliver toxic effectors directly into target cells. Most T6SSs mediate antibacterial activities, whereas the potential anti-eukaryotic role of T6SS remains understudied.
Hadar Cohen +5 more
doaj +1 more source
Gasdermin E suppresses tumor growth by activating anti-tumor immunity
Nature, 2020 Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)—mutated in familial ageing-related hearing loss2—can be cleaved by caspase 3 ...
Zhibin Zhang +13 more
semanticscholar +1 more source
Pyroptosis: Role and Mechanisms in Cardiovascular Disease
Frontiers in Cardiovascular Medicine, 2022 Cardiovascular disease (CVD) is a common disease that poses a huge threat to human health. Irreversible cardiac damage due to cardiomyocyte death and lack of regenerative capacity under stressful conditions, ultimately leading to impaired cardiac ...
Xinzhe Chen +4 more
doaj +1 more source
Cells, 2023 Psoriasis is a frequent and incurable skin disease whose pathogenesis is still not fully understood. It is characterized by immune disturbances leading to hyperproliferation and improper differentiation of keratinocytes.
Julia Nowowiejska +6 more
doaj +1 more source
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012 Review on GSDMB (gasdermin B), with data on DNA, on the protein encoded, and where the gene is implicated.
Tamura, M, Shiroishi, T
openaire +3 more sources
Gasdermin-B promotes invasion and metastasis in breast cancer cells [PDF]
, 2014 Gasdermin B (GSDMB) belongs to the Gasdermin protein family that comprises four members (GSDMA-D). Gasdermin B expression has been detected in some tumor types such as hepatocarcinomas, gastric and cervix cancers; and its overexpression has been related ...
Abril, Sandra +11 more
core +8 more sources