Results 31 to 40 of about 24,180 (354)
Pyroptosis Modulators: New Insights of Gasdermins in Health and Disease
Antioxidants, 2023 Pyroptosis is an inflammation-dependent type of cell death that has been in the spotlight for the scientific community in the last few years. Crucial players in the process of pyroptosis are the members of the gasdermin family of proteins, which have ...
Imane Allali-Boumara +4 more
doaj +1 more source
Pyroptosis- What We Know and the Road Ahead! [PDF]
Journal of Clinical and Diagnostic Research, 2022 Pyroptosis, a type of cell death, initiated by proinflammatory signals, is classically associated with inflammation. It was thought to occur mainly in macrophages and leukocytes during inflammatory conditions and involves the activation of caspase 1 ...
Anitha Krishnan Pandarathodiyil +3 more
doaj +1 more source
NLRP3 Inflammasome and Pyroptosis in Liver Pathophysiology: The Emerging Relevance of Nrf2 Inducers
Antioxidants, 2022 Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial regulators of the inflammatory response through the activation of Caspase-1 ...
Laura Hurtado-Navarro +4 more
doaj +1 more source
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome [PDF]
, 2020 Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome ...
Atmosukarto, Ines I. +21 more
core +5 more sources
Pyroptosis: shedding light on the mechanisms and links with cancers
Frontiers in Immunology, 2023 Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and the release of intracellular proinflammatory contents,
Hong-mei You +5 more
doaj +1 more source
The Versatile Gasdermin Family: Their Function and Roles in Diseases
Frontiers in Immunology, 2021 The gasdermin (GSDM) family, a novel group of structure-related proteins, consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF. GSDMs possess a C-terminal repressor domain, cytotoxic N-terminal domain, and flexible linker domain (except ...
Ju Zou +9 more
doaj +1 more source
Gasdermins assemble; recent developments in bacteriology and pharmacology
Frontiers in Immunology, 2023 The discovery of gasdermin D (GSDMD) as the terminal executioner of pyroptosis provided a large piece of the cell death puzzle, whilst simultaneously and firmly putting the gasdermin family into the limelight.
Claudine S. Greenwood +4 more
doaj +1 more source
ASC filament formation serves as a signal amplification mechanism for inflammasomes [PDF]
, 2016 A hallmark of inflammasome activation is the ASC speck, a micrometre-sized structure formed by the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD), which consists of a pyrin domain (PYD) and a caspase ...
Broz, Petr +4 more
core +1 more source
Gasdermins and their role in immunity and inflammation [PDF]
Journal of Experimental Medicine, 2019 The gasdermins are a family of pore-forming proteins recently implicated in the immune response. One of these proteins, gasdermin D (GSDMD), has been identified as the executioner of pyroptosis, an inflammatory form of lytic cell death that is induced upon formation of caspase-1–activating inflammasomes.
Egil Lien +5 more
openaire +3 more sources
Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. [PDF]
, 2017 Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged, they progress to a lytic and inflammatory phase called secondary necrosis.
Alnemri, Diana +5 more
core +2 more sources