Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors
Frontiers in Immunology, 2023 Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important self-protection mechanisms against stimuli and infections. Hosts can defend against intracellular bacterial infections by inducing cell pyroptosis, which triggers the ...
Zhen Dai +5 more
semanticscholar +1 more source
Unconventional protein secretion by gasdermin pores [PDF]
Seminars in Immunology, 2023 Unconventional protein secretion (UPS) allows the release of specific leaderless proteins independently of the classical endoplasmic reticulum (ER)-Golgi secretory pathway. While it remains one of the least understood mechanisms in cell biology, UPS plays an essential role in immunity as it controls the release of the IL-1 family of cytokines, which ...
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Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice [PDF]
Proceedings of the National Academy of Sciences, 2023 Gasdermins (GSDMs) share a common functional domain structure and are best known for their capacity to form membrane pores. These pores are hallmarks of a specific form of cell death called pyroptosis and mediate the secretion of pro-inflammatory cytokines such as interleukin 1β (IL1β) and interleukin 18 (IL18).
Fattinger, Stefan A. +16 more
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Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
Livers, 2022 Acetaminophen (APAP) is a widely used pain reliever that can cause liver injury or liver failure in response to an overdose. Understanding the mechanisms of APAP-induced cell death is critical for identifying new therapeutic targets.
Hartmut Jaeschke +2 more
doaj +1 more source
Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]
, 2019 For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María +3 more
core +1 more source
Recombinant DnaK orally administered protects axenic European sea bass against vibriosis [PDF]
, 2020 Vibrio anguillarum causes high mortality in European sea bass (Dicentrarchus labrax) larviculture and is a hindering factor for successful sustainable aquaculture of this commercially valuable species.
Bajek, Aline +6 more
core +2 more sources
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
core +2 more sources
Molecular and structural aspects of gasdermin family pores and insights into gasdermin-elicited programmed cell death [PDF]
Biochemical Society Transactions, 2021 Pyroptosis is a highly inflammatory and lytic type of programmed cell death (PCD) commenced by inflammasomes, which sense perturbations in the cytosolic environment. Recently, several ground-breaking studies have linked a family of pore-forming proteins known as gasdermins (GSDMs) to pyroptosis.
Tengchuan Jin +3 more
openaire +3 more sources
Research Progress of Pyroptosis in Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2022 Alzheimer’s disease (AD) is a disease characterized by insidious and progressive neurodegeneration, with clinical syndromes of memory and visuospatial skills damage.
Weiyue Xue, Di Cui, Ye Qiu
doaj +1 more source
Role of Pyroptosis in Inflammatory Bowel Disease (IBD): From Gasdermins to DAMPs
Frontiers in Pharmacology, 2022 Pyroptosis is a pro-inflammatory cell death executed by gasdermin family proteins that involve the formation of pores on cells, recognition of danger signals, and release of pro-inflammatory cytokines IL-1β and IL-18.
Shuxia Zhang +4 more
doaj +1 more source