NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. [PDF]
, 2017 Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood ...
Nichols, Randilea D +2 more
core +2 more sources
The role of pyroptosis and its crosstalk with immune therapy in breast cancer
Frontiers in Immunology, 2022 Pyroptosis is a brand-new category of programmed cell death (PCD) that is brought on by multitudinous inflammasomes, which can recognize several stimuli to pilot the cleavage of and activate inflammatory cytokines like IL-18 and IL-1β is believed to have
Ling Wu +7 more
doaj +1 more source
The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
core +3 more sources
Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture [PDF]
, 2019 Pyroptosis is rapidly emerging as a mechanism of anti-microbial host defense, and of extracellular release of the inflammasome-dependent cytokines interleukin (IL)-1 beta and IL-18, which contributes to autoinflammatory pathology. Caspases 1, 4, 5 and 11
Lamkanfi, Mohamed +4 more
core +1 more source
‘Hints’ in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death [PDF]
Cell Death & Differentiation, 2017 Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis, necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases cleave a gasdermin D (GSDMD) protein to generate a 31 kDa N-terminal domain.
Qiu, Shiqiao, Liu, Jing, Xing, Feiyue
openaire +2 more sources
Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
Biomolecules, 2022 Ischemia-reperfusion (I/R) injury, uncommon among patients suffering from myocardial infarction, stroke, or acute kidney injury, can result in cell death and organ dysfunction.
Yu Zheng +3 more
doaj +1 more source
P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis? [PDF]
, 2016 Transglutaminases have important roles in stabilizing extracellular protein assemblies in tissue repair processes but some reaction products can stimulate immune activation, leading to chronic inflammatory conditions or autoimmunity.
Aeschlimann, Daniel, Knauper, Vera
core +1 more source
Supplementary Figure from Raptinal Induces Gasdermin E–Dependent Pyroptosis in Naïve and Therapy-Resistant Melanoma [PDF]
, 2023 Mégane Vernon +7 more
openalex +3 more sources
Not sorcery after all: Roles of multiple charged residues in membrane insertion of gasdermin-A3
Frontiers in Cell and Developmental Biology, 2022 Gasdermins execute programmatory cell death, known as pyroptosis, by forming medium-sized membrane pores. Recently, the molecular structure of those pores as well as the diversity in their shape and size have been revealed by cryoTEM and atomic force ...
Viktoria Korn, Kristyna Pluhackova
doaj +1 more source
Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]
, 2017 The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke +14 more
core +2 more sources