Results 131 to 140 of about 20,660 (301)

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice [PDF]

, 2016
Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and in populations with chronic conditions such as renal failure, diabetes, HIV and alcohol abuse.
Allison, Cody, Doerflinger, Marcel, Glab, Jason, Hotchkiss, Richard S, Jose, Irvin, Lin, Ann, Nedeva, Christina, O’Reilly, Lorraine, Pellegrini, Marc, Puthalakath, Hamsa   +9 more
core   +2 more sources

Refractory Lung Diseases: From Cellular Structures, Molecular Mechanisms to Therapeutic Strategies

Pediatric Discovery, EarlyView.
ABSTRACT Refractory lung diseases (RLDs) encompass a spectrum of progressive pulmonary disorders, including acute respiratory distress syndrome (ARDS), bronchopulmonary dysplasia (BPD), and idiopathic pulmonary fibrosis (IPF). These conditions are defined by poor responsiveness to current therapeutic interventions and pose substantial clinical ...
Yiheng Qiu, Xiangyu Dong, Yi Zhu, Nicole Miranda, Awele Chukwura, Yan Peng, Sarina Zhao, Michelle Xiang, Peyton McGuire, Ava Zou, Lucas Zhang, Jiaming Fan, Linghuan Zhang   +12 more
wiley   +1 more source

Pyroptosis in Spinal Cord Injury: Implications for Pathogenesis and Therapeutic Approaches

Frontiers in Bioscience-Landmark
Traumatic spinal cord injury (SCI) is a serious disease of the central nervous system. Aside from the limited intrinsic regenerative capacity of neurons, complex microenvironmental disturbances can also lead to further cellular damage and growth ...
Guangjin Gu, Huaqi Yu, Huishuang Zou, Wenjuan Kou, Pingping Zhang, Guangjie Gu, Jie Lu, Weihan Shi, Pengcheng Chu, Yaning Zhang, Guangwei Sun, Jun Shang   +11 more
doaj   +1 more source

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core  

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

The killer protein Gasdermin D [PDF]

Cell Death & Differentiation, 2016
John A Wright, Clare E Bryant
openaire   +1 more source

Gasdermin D Mediates Endoplasmic Reticulum Stress by FAM134B to Regulate Cardiomyocyte Autophagy and Apoptosis in Doxorubicin-induced Cardiotoxicity [PDF]

, 2022
Junbo Ge, Yanan Qu, Rifeng Gao, Xiang Wei, Xiaolei Sun, Kun Yang, Huairui Shi, Yang Gao, Shiyu Hu, Yiwen Wang, Jie Yang, Aijun Sun, Feng Zhang   +12 more
openalex   +1 more source

Pathogenesis of Age‐Related Hearing Loss and Therapeutic Strategies

Sensory Neuroscience, EarlyView.
ABSTRACT Age‐related hearing loss (ARHL) is a degenerative disorder of the auditory system, characterized by bilateral symmetrical sensorineural hearing loss that occurs with aging. As a highly prevalent age‐related condition worldwide, ARHL significantly impairs both the quality of life and mental health of the elderly.
Yu Xiao, Jiaxin Liu, Xiaohan Zhang, Miao Chang, Cheng Cheng, Yunhao Wu, Xiaolong Fu   +6 more
wiley   +1 more source

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

Neural Regeneration Research
Microglia, the resident monocyte of the central nervous system, play a crucial role in the response to spinal cord injury. However, the precise mechanism remains unclear.
Wei Zhang, Yubao Lu, Ruoqi Shen, Yingjie Wu, Chenrui Liu, Xingxing Fang, Liangming Zhang, Bin Liu, Limin Rong   +8 more
doaj   +1 more source