The Role of Pyroptosis in Alzheimer's Disease
Journal of Integrative Neuroscience, 2023 Pyroptosis is a type of regulated cell death that relies on caspases, vesicles, and the cleavage of gasdermin proteins (which create pores in the cell membrane).
Yanxiu Ju +3 more
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, 2018 In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation.
Sandstrom, Andrew, VANCE, Russell E.
core +1 more source
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor [PDF]
Acta Crystallographica Section A Foundations and Advances, 2018 Significance The inflammasomes are signaling platforms that promote the activation of inflammatory caspases such as caspases-1, -4, -5, and -11, which cleave gasdermin D (GSDMD) to induce pyroptotic cell death. The mechanisms of GSDMD recognition by inflammatory caspases remain poorly understood.
Jie Yang +10 more
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The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomes. [PDF]
, 2018 Activation of the inflammasome pathway is crucial for effective intracellular host defense. The mitochondrial network plays an important role in inflammasome regulation but the mechanisms linking mitochondrial homeostasis to attenuation of inflammasome ...
Alnemri, Emad S. +9 more
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Gasdermin D activity in inflammation and host defense [PDF]
Science Immunology, 2019 This Review summarizes our current understanding of the functions of gasdermin D.
Judy Lieberman +2 more
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Caspase-1 initiates apoptosis in the absence of gasdermin D
Nature Communications, 2019 In inflammasomes, caspase-1 activation leads to pyroptosis mediated by gasdermin D, but cells lacking gasdermin-D still initiate caspase-dependent cell death. Here, Tsuchiya et al. show that these cells undergo Bid- and caspase-3-dependent apoptosis.
Kohsuke Tsuchiya +14 more
doaj +1 more source
NAIP/NLRC4 inflammasome activation in MRP8+ cells is sufficient to cause systemic inflammatory disease. [PDF]
, 2017 Inflammasomes are cytosolic multiprotein complexes that initiate protective immunity in response to infection, and can also drive auto-inflammatory diseases, but the cell types and signalling pathways that cause these diseases remain poorly understood ...
Nichols, Randilea D +2 more
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Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture [PDF]
, 2019 Pyroptosis is rapidly emerging as a mechanism of anti-microbial host defense, and of extracellular release of the inflammasome-dependent cytokines interleukin (IL)-1 beta and IL-18, which contributes to autoinflammatory pathology. Caspases 1, 4, 5 and 11
Lamkanfi, Mohamed +4 more
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Bacillus cereus cytotoxin K triggers gasdermin D-dependent pyroptosis
Cell Death Discovery, 2022 AbstractBacillus cereus is well known as a causative agent of foodborne gastrointestinal diseases and systemic non-gastrointestinal diseases. We have recently identified a pathogenic B. cereus (named H2) from a deep-sea cold-seep. H2 possesses the pyroptosis-inducing capacity and contains a number of enterotoxins including cytotoxin K (CytK).
Yan Zhao, Li Sun
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Gasdermin D: A Potential New Auxiliary Pan-Biomarker for the Detection and Diagnosis of Diseases
Biomolecules, 2023 Pyroptosis is a form of programmed cell death mediated by gasdermins, particularly gasdermin D (GSDMD), which is widely expressed in tissues throughout the body.
Ningyi Wan +8 more
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