Results 141 to 150 of about 12,681 (203)

Foot-and-Mouth Disease Virus Induces Porcine Gasdermin E-Mediated Pyroptosis through the Protease Activity of 3C^pro. [PDF]

J Virol, 2023
Ren X, Yin M, Zhao Q, Zheng Z, Wang H, Lu Z, Li X, Qian P.   +7 more
europepmc   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells. [PDF]

Cell Commun Signal, 2023
Xu L, Shi F, Wu Y, Yao S, Wang Y, Jiang X, Su L, Liu X.   +7 more
europepmc   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Dual function of Gasdermin E: pyroptosis-mediated pan-cancer suppression versus HCC-specific oncogenic activity. [PDF]

Front Immunol
Kahaer G, Pan S, Yang C, Xie W, Lu Y.
europepmc   +1 more source

Die Rolle des entzündlichen Zelltods bei Typ‐1‐dominanten entzündlichen Hautkrankheiten

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 8, Page 1047-1051, August 2026.
Zusammenfassung Während es in den letzten Jahren große Fortschritte bei der Entwicklung neuer Therapien für die Psoriasis und die atopische Dermatitis gab, ist die Innovation im Bereich der Typ‐1‐dominanten Hautkrankheiten immer noch überschaubar. Zu dieser Gruppe zählt man all jene Erkrankungen, bei denen es zu einer zytotoxischen Immunreaktion gegen ...
Felix Lauffer
wiley   +1 more source

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, Volume 111, Issue 8, Page 3557-3569, 1 August 2026.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source

SNS‑032 combined with decitabine induces caspase‑3/gasdermin E‑dependent pyroptosis in breast cancer cells. [PDF]

Oncol Lett
Chen Y, Zhang D, Li J, Sun Y, Wang J, Xi L.   +5 more
europepmc   +1 more source

Oxypeucedanin alleviates cisplatin-induced intestinal toxicity through impairing caspase-3/gasdermin E signaling. [PDF]

J Vet Med Sci
Wang R, Gao F, Hao L, Zhang J, Chen Z, Song D, Gao F, He W, Zhao K, Guan J.   +9 more
europepmc   +1 more source

Pterostilbene induces pyroptosis in mouse breast cancer cells through the caspase-3/Gasdermin E signaling pathway and reshapes the tumor immune microenvironment. [PDF]

Transl Oncol
Huang X, Yang W, Hu X, Peng L, Dong J, Li L.   +5 more
europepmc   +1 more source