Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential
Clinical &Experimental Allergy, EarlyView.Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole +4 more
wiley +1 more source
Cell Proliferation, EarlyView.Excessive mechanical stress induces nucleus pulposus cell pyroptosis and intervertebral disc degeneration. Itgb1 inhibits MNAT1‐mediated ubiquitination and degradation of Vimentin. Vimentin alleviates excessive mechanical stress‐induced nucleus pulposus cell pyroptosis and intervertebral disc degeneration through PINK1‐Parkin‐dependent mitophagy ...
Xuening Liu +7 more
wiley +1 more source
Myo1g Mediates NKR‐P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity
Immunology, EarlyView.In this study we analysed the participation of Myosin 1g in the development and functions of murine natural killer (NK) cells; we found that Myosin 1g is expressed in murine‐activated primary NK cells from the spleen. Additionally, in the absence of Myosin 1g, correlates with a reduced expression of NKR‐P1C but not of CD49b or NKp46.
Héctor Romero‐Ramírez +3 more
wiley +1 more source
Irradiation Induces Gasdermin E-Triggered Tumor Immunity to Inhibit Esophageal Carcinoma Cell Survival. [PDF]
ACS Omega, 2023 Tan B, Wang N, Yang S, Liu H, Cheng Y.
europepmc +1 more source
Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death
Journal of Periodontal Research, EarlyView.Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee +2 more
wiley +1 more source
Berberine Alleviates <i>Citrobacter rodentium</i>-Induced Colitis with Reduced Epithelial Gasdermin E-Mediated Pyroptosis. [PDF]
Int J Mol SciZhang M +10 more
europepmc +1 more source
Gasdermin D-independent IL-1ß secretion by living human monocytic cells
, 2018 Interleukin-1β (IL-1β), a major pro-inflammatory cytokine, is a leaderless cytosolic protein whose secretion does not follow the classical endoplasmic reticulum-to-Golgi pathway, and for which the mechanism of secretion remains to be established.
Six, Charlotte
core
Exploring the Post Cleavage Interactions of Gasdermin E
Pyroptosis is a type of programmed cell death activated by lethal stimuli to cleave gasdermins (GSDMs) into N-terminal pore forming and C-terminal autoinhibitory domains. Pyroptosis leads to inflammation which can be harnessed for host defense during infection and to promote anti-tumor immunity.
openaire +1 more source
Metabolic reprogramming of the immune response in periodontitis
Periodontology 2000, EarlyView.Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon +3 more
wiley +1 more source
Redefining Shiga toxin-induced human cell death as NLRP1- and gasdermin E-mediated pyroptosis. [PDF]
Proc Natl Acad Sci U S ARicci-Azevedo R +8 more
europepmc +1 more source