Results 161 to 170 of about 30,930,304 (249)

Paeonol Alleviate Cisplatin‐ and Noise‐Induced Hearing Loss by Preserving Hair Cell Ribosome Biogenesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Paeonol protects against cisplatin‐ and noise‐induced hearing loss by mitigating oxidative damage and preserving protein homeostasis in cochlear hair cells, revealing a novel mechanism involving ribosome biogenesis. ABSTRACT Background Hearing loss primarily results from irreversible cochlear hair cell (HC) damage caused by factors such as noise, aging,
Minhui Xia, Tianshi Sun, Wenyu Hou, Yiyun Lou, Yunjie Li, Hua Jiang, Hui Chai, Jiaoyao Ma, Mingyu Xia   +8 more
wiley   +1 more source

A high-throughput Gaussia luciferase reporter assay for screening potential gasdermin E activators against pancreatic cancer. [PDF]

Acta Pharm Sin B, 2023
Liu Y, Zhang X, Zhang P, He T, Zhang W, Ma D, Li P, Chen J.   +7 more
europepmc   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-mediated pyroptosis in intestinal epithelial cells. [PDF]

J Transl Med
Zhou Q, Liu L, Lin X, Shen B, Huang W, Zhang Y, Li Y, Yang Y, Liu H, Zhang W, Zhao X, Qiao W, Liu Y, Tan G, Zhi F.   +14 more
europepmc   +1 more source

4‐2 VHL‐Recruiting PROTAC Inhibits the Growth and Migration of Triple Negative Breast Cancer Cells by Triggering Pyroptosis Through Fas‐Mediated IL‐17 Signaling

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT SND1 is an oncoprotein found to be overexpressed in breast cancer, especially in triple‐negative breast cancer(TNBC). In our previous study, a novel SND1‐interacting peptide 4‐2 was identified, exhibiting cytotoxicity to TNBC cells by inducing SND1 degradation.
Qiqi Wang, Qiufeng Huang, Huiping Ou, Tingting Huang, Yunjiao He, Peng Li   +5 more
wiley   +1 more source

Gasdermin E-mediated intestinal epithelial pyroptosis promotes chemically induced colitis in mice. [PDF]

Gastroenterol Rep (Oxf)
Wu YZ, Xie Y, Chen L, Ning L, Hu XQ, Xu XP.   +5 more
europepmc   +1 more source

Foot-and-Mouth Disease Virus Induces Porcine Gasdermin E-Mediated Pyroptosis through the Protease Activity of 3C^pro. [PDF]

J Virol, 2023
Ren X, Yin M, Zhao Q, Zheng Z, Wang H, Lu Z, Li X, Qian P.   +7 more
europepmc   +1 more source

Inflammatory Factors in Allergic Rhinitis: A 20‐Year Bibliometric Mapping and Emerging Trends

Flavour and Fragrance Journal, Volume 41, Issue 5, Page 1076-1089, September 2026.
This figure illustrates the bibliometric process and results of research on inflammatory factors of allergic rhinitis from 2004 to 2024 including data screening, global distribution, collaborative networks and the evolution of research hotspots. ABSTRACT Allergic rhinitis (AR) is driven by a network of inflammatory mediators released by mast cells ...
Shanshan Jing, Fengying Zhang, Qiqi Liu
wiley   +1 more source

Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells. [PDF]

Cell Commun Signal, 2023
Xu L, Shi F, Wu Y, Yao S, Wang Y, Jiang X, Su L, Liu X.   +7 more
europepmc   +1 more source

Synthetic Food Colorants and Gut Microbiota: A Systematic Review of Preclinical Studies

Food Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Growing evidence suggests that industrial food processing, including the excess consumption of food additives, might have a negative impact on human health. Despite regulatory safety evaluations, their impact on gut microbiota remains poorly characterized.
Sebastiano Alfio Torrisi, Federica Martina Di Domenico, Gian Marco Leggio, Giuseppe Caruso, Evelyn Frias‐Toral, Nohora Milena Martínez López, Agnieszka Micek, Marialaura Bonaccio, Justyna Godos, Giuseppe Grosso   +9 more
wiley   +1 more source