Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation. [PDF]
Cell Death DisLong F +10 more
europepmc +1 more source
CHOP-mediated Gasdermin E expression promotes pyroptosis, inflammation, and mitochondrial damage in renal ischemia-reperfusion injury. [PDF]
Cell Death DisMa N +9 more
europepmc +1 more source
Gasdermin E benefits CD8+T cell mediated anti-immunity through mitochondrial damage to activate cGAS-STING-interferonβ axis in colorectal cancer. [PDF]
Biomark ResLuo B +5 more
europepmc +1 more source
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Caspase-3 and gasdermin E detection in peri-implantitis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021Peri-implantitis could lead to progressive bone loss and implant failure; however, the mechanism of peri-implantitis remains unclear. Based on emerging evidence, pyroptosis, a novel proinflammatory programmed death, contributes to different oral infectious diseases.
Chaozhen, Chen +7 more
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USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer
Cancer Research, 2023Abstract Pyroptosis is a type of programmed cell death characterized by the activation of inflammatory caspases and the cleavage of gasdermin proteins. Pyroptosis can suppress tumor development and induce antitumor immunity, and activating pyroptosis is a potential treatment strategy for ...
Yidan Ren +11 more
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Inducing Pyroptosis via Gasdermin B and Gasdermin E Cleavage
2023Gasdermin B (GSDMB) and gasdermin E (GSDME) are two members of the gasdermin family, which shares a conservative gasdermin-N domain capable of executing pyroptotic cell death, through perforating the plasma membrane from inside of the cell. Both GSDMB and GSDME are autoinhibited in the resting stage and require proteolytic cleavage to unleash the pore ...
Zhiwei, Zhou, Yupeng, Wang, Feng, Shao
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Caspase‐3 and gasdermin E mediate macrophage pyroptosis in periodontitis
Journal of Periodontal Research, 2023AbstractBackground and ObjectivesPeriodontitis is a chronic inflammatory disease linked to pyroptosis, an inflammatory cell death process. Macrophages are essential for maintaining microenvironment homeostasis, which is crucial for periodontal health.
Xiangru Gao +9 more
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Role of Gasdermin E in the Biogenesis of Apoptotic Cell–Derived Exosomes
The Journal of Immunology, 2023Abstract The gasdermins are a family of pore-forming proteins that has recently been suggested to play a central role in pyroptosis. In this study, we describe the novel roles of gasdermins in the biogenesis of apoptotic cell–derived exosomes.
Jaehark Hur +15 more
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Molecular mechanisms and therapeutic relevance of gasdermin E in human diseases
Cellular Signalling, 2022Gasdermin E (GSDME) is one of the main members of the GSDM family and is originally involved in hereditary hearing loss. Recent studies have reported that GSDME expression is epigenetically silenced by methylation in several common tumours, thereby enhancing tumour proliferation and metastasis.
Jiabing, Wang +4 more
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Zebrafish gasdermin E cleavage-engaged pyroptosis by inflammatory and apoptotic caspases
Developmental & Comparative Immunology, 2021As the executor of pyroptosis known to date, gasdermins (GSDMs), consists of GSDMA, GSDMB, GSDMC, GSDMD, GSDME and pejvakin, might play critical roles in anti-bacterial infection as well as inflammatory diseases. However, zebrafish only harbors a pair of Gsdme (Gsdmea/b), and their activation mechanisms remain largely unknown.
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