Results 181 to 190 of about 30,930,304 (249)

Dysregulation of the KLF9/TXNRD2 Axis Leads to Mitochondrial DNA Oxidation and NLRP3 Inflammasome Activation in Ulcerative Colitis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
In ulcerative colitis, the transcription factor KLF9 is abnormally overexpressed and inhibits TXNRD2 transcription. As a key mitochondrial antioxidant enzyme, the loss of TXNRD2 leads to disruption of mitochondrial redox homeostasis, resulting in excessive accumulation of mtROS and mitochondrial DNA damage.
Yijia Fan, Lingling Dai, Feng Zhu, Mingfang Ping, Xiaofeng Zhu, Junguo Chen   +5 more
wiley   +1 more source

Arming oncolytic M1 virus with gasdermin E enhances antitumor efficacy in breast cancer. [PDF]

iScience
Chen XY, Liu Y, Zhu WB, Li SH, Wei S, Cai J, Lin Y, Liang JK, Yan GM, Guo L, Hu C.   +10 more
europepmc   +1 more source

Medicarpin Mediates the Protective Effect of Cell Pyroptosis Against Sepsis‐Induced Liver Injury by NLRP3/GSDMD/Caspase‐1 Axis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Med reduces pyroptosis in LPS‐induced THLE‐2 cells by inactivating NLRP3/GSDMD/caspase‐1, thereby exerting a protective effect in sepsis‐induced liver injury. ABSTRACT The liver is a decisive organ that is damaged by sepsis. Medicarpin (Med) is a principal wing‐type final product of 5‐deoxyisoflavone sub‐branch in M.
Pengfei Chen, Weifeng Jiang
wiley   +1 more source

Pyroptosis‐Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Current advances in tumour immunotherapy remain constrained by inadequate cytotoxic T lymphocyte activation and the immunosuppressive tumour microenvironment. Innovative strategies are urgently required to enhance anti‐tumour immune potency for clinical improvements in immunotherapy‐resistant malignancies.
Geng Dou, Jiani Liu, Ran Tian, Keying Zhang, Meng Suo, Ding Zhou, Yipeng Zhang, Xuemei Liu, Xinyu Qiu, Jinxin Kuang, Zhaonan Zou, Shuchang Wang, Lu Zhao, Feng Ding, Di Wang, Congcong Guan, Xiaoyu Zhu, Dongyao Wang, Siying Liu, Tianfu Zhang, Yimin Zhao, Shiyu Liu   +21 more
wiley   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Targeting hepcidin in colorectal cancer triggers a TNF-dependent-gasdermin E-driven immunogenic cell death response. [PDF]

Exp Hematol Oncol
Di Grazia A, Franzè E, Frascatani R, Laudisi F, Pacifico T, Tomassini L, Di Fusco D, Formica V, Sica G, Stolfi C, Monteleone I, Monteleone G.   +11 more
europepmc   +1 more source

Proteomics‐Based Identification of the Pyroptosis‐Related Biomarker PCSK9 and Its Association With the Pathogenesis of Rheumatoid Arthritis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang, Hao‐Jie Chen, Ting‐Ting Wu, Xin‐Yi Shen, Ying‐Ying Gao, Yu‐Feng Yin, Tian Ren, Xin Chu, Jing Cao, Tao Cheng, Ming‐Jun Wang   +10 more
wiley   +1 more source

Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD-Like Receptor Family Protein 3/Gasdermin E-Mediated Pyroptosis in Pulmonary Arterial Hypertension. [PDF]

J Am Heart Assoc
Tian XT, Peng ZY, Wu YS, Cao YY, Li XC, Li Y, Tang SY, Chen AF, Li XH.   +8 more
europepmc   +1 more source

Gasdermin E activation in Crohn's Disease.

openaire   +2 more sources

RBMX Transcriptionally Repressed by EZH2‐Associated H3K27me3 Modification Attenuates Pyroptosis in Renal Ischemia/Reperfusion Injury via Regulating SIRT3/NLRP3 Inflammasome Activation

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Ischemic reperfusion injury (IRI) to kidney is a significant clinical factor in acute kidney injury (AKI). This study aimed to investigate the new role of RNA‐binding motif protein X‐linked (RBMX), a modulator of m6A methylation, in renal IRI and to examine the associated regulatory mechanisms. An in vitro renal IRI model was established using
Yi‐Han Wang, Yan Teng, Fang‐Lan Yao, Shu‐Qi Wei, Yan Li   +4 more
wiley   +1 more source