Results 201 to 210 of about 30,930,304 (249)

Systemic impact of intramuscular snake envenomation and intravenous immunoglobulin‐based antivenom treatment on murine plasma proteome and peptidome

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Snake envenomation remains a critical global public health challenge. In Brazil, the genus Bothrops is responsible for most accidents, typically resulting in coagulopathy, hemorrhage, and renal failure. Despite its clinical prevalence, the molecular mechanisms driving plasma protein disturbances remain poorly understood.
Bianca C. S. C. de Barros, Alison F. A. Chaves, Mariana S. L. C. Morone, Ana T. A. Sachetto, Marcelo L. Santoro, Oliver Schilling, Solange M. T. Serrano   +6 more
wiley   +1 more source

Gasdermin-E-Dependent Non-Canonical Pyroptosis Promotes Drug-Induced Liver Failure by Promoting CPS1 deISGylation and Degradation. [PDF]

Adv Sci (Weinh)
Ouyang SX, Zhu JH, Cao Q, Liu J, Zhang Z, Zhang Y, Wu JW, Sun SJ, Fu JT, Chen YT, Tong J, Liu Y, Zhang JB, Shen FM, Li DJ, Wang P, Wang P.   +16 more
europepmc   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation. [PDF]

Cell Death Dis
Long F, Wei X, Chen Y, Li M, Lian N, Yu S, Chen S, Yang Y, Li M, Gu H, Chen X.   +10 more
europepmc   +1 more source

Apigenin Alleviates Pyroptosis in Lung Adenocarcinoma Cells by Modulating TNF‐α/NF‐κB Signaling and AIM2 Inflammasome Activation

Thoracic Cancer, Volume 17, Issue 17, September 2026.
Apigenin attenuated CCCP/FeSO4‐induced injury and pyroptosis‐associated molecular changes in A549 cells by suppressing TNF‐α/NF‐κB signaling and reducing AIM2/ASC‐associated protein expression. Integrated network pharmacology, molecular docking, molecular dynamics simulations, and LUAD transcriptomic analyses further prioritized TNF and AIM2 as ...
Kairui Zhu, Yulong Mu, Zhenguo Su, Zhen Yue, Dongyang Wu, Guiwu Qu, Chenyang Jiang, Qing Li, Youjie Li, Ning Xie   +9 more
wiley   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

CHOP-mediated Gasdermin E expression promotes pyroptosis, inflammation, and mitochondrial damage in renal ischemia-reperfusion injury. [PDF]

Cell Death Dis
Ma N, Lu H, Li N, Ni W, Zhang W, Liu Q, Wu W, Xia S, Wen J, Zhang T.   +9 more
europepmc   +1 more source

Gasdermin E benefits CD8⁺T cell mediated anti-immunity through mitochondrial damage to activate cGAS-STING-interferonβ axis in colorectal cancer. [PDF]

Biomark Res
Luo B, Zhang S, Yu X, Tan D, Wang Y, Wang M.   +5 more
europepmc   +1 more source

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Caspase-3 and gasdermin E detection in peri-implantitis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2021
Peri-implantitis could lead to progressive bone loss and implant failure; however, the mechanism of peri-implantitis remains unclear. Based on emerging evidence, pyroptosis, a novel proinflammatory programmed death, contributes to different oral infectious diseases.
Chaozhen, Chen, Zhiwei, Jiang, Qifeng, Jiang, Wei, Dai, Qin, Shao, Qianming, Chen, Ying, Wang, Guoli, Yang   +7 more
openaire   +2 more sources

USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer

Cancer Research, 2023
Abstract Pyroptosis is a type of programmed cell death characterized by the activation of inflammatory caspases and the cleavage of gasdermin proteins. Pyroptosis can suppress tumor development and induce antitumor immunity, and activating pyroptosis is a potential treatment strategy for ...
Yidan Ren, Maoxiao Feng, Xiaodong Hao, Xiaoyan Liu, Juan Li, Peilong Li, Jie Gao, Qiuchen Qi, Lutao Du, Chuanxin Wang, Qin Wang, Yunshan Wang   +11 more
openaire   +2 more sources