Results 221 to 230 of about 30,930,304 (249)

Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis

Apoptosis, 2022
Oral squamous cell carcinoma (OSCC) is a malignant tumor with high mortality and poor prognosis. Many OSCC patients have low response rate to current treatments including immunotherapies largely due to the immune-suppressive tumor microenvironment (TME). Chemotherapy could induce immunogenic cell death (ICD), a type of cell death such as pyroptosis and
Mei Zi, Chen Xingyu, Chen Yang, Su Xiaodong, Lv Shixian, Wei Shicheng   +5 more
openaire   +2 more sources

Insight into the structure, function and the tumor suppression effect of gasdermin E

Biochemical Pharmacology
Gasdermin E (GSDME), which is also known as DFNA5, was first identified as a deafness-related gene that is expressed in cochlear hair cells, and mutation of this gene causes autosomal dominant neurogenic hearing loss. Later studies revealed that GSDME is mostly expressed in the kidney, placenta, muscle and brain cells, but it is expressed at low levels
Yuge, Long, Xiaoyuan, Jia, Liang, Chu
openaire   +2 more sources

Gasdermin E shields PDAC

Nature Reviews Cancer, 2022
openaire   +2 more sources

Gasdermin E as a potential target and biomarker for CRISPR-Cas9-based cancer therapy

Biochemical Pharmacology
Gasdermin E (GSDME), a protein pivotal in mediating pyroptosis, has gained significant attention due to its role in cancer pathogenesis and its potential as a therapeutic target. The advent of CRISPR-Cas9, a precise genome editing tool, has revolutionized cancer therapy by enabling the manipulation of GSDME expression and function. This review explores
Mojtaba Tarin, Amir Sh. Saljooghi
openaire   +2 more sources

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Cell, 2021
Iva Hafner Bratković, John Doench, Martin W Lafleur   +2 more
exaly  

Pyroptosis and the cellular consequences of gasdermin pores

Seminars in Immunology, 2023
Susan L Fink
exaly  

Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

Cell Reports, 2021
Kohsuke Tsuchiya, Takashi Suda, Hideki Hara   +2 more
exaly  

Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis

Journal of Molecular Biology, 2022
Chengliang Wang, Jianbin Ruan
exaly  

Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity

International Journal of Molecular Sciences, 2021
Kohsuke Tsuchiya
exaly  

Developing Detection Tools for Gasdermin E

Genetic Engineering & Biotechnology News, 2018
openaire   +1 more source