The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation. [PDF]
ElifeXu H, Yuan Z, Qin K, Jiang S, Sun L.
europepmc +1 more source
Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 9, September 2026.Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li +3 more
wiley +1 more source
Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder. [PDF]
BrainFernandes JP +6 more
europepmc +1 more source
Ferroptosis: Newly Emerged Regulator for Human Disease
MedComm, Volume 7, Issue 9, September 2026.Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao +4 more
wiley +1 more source
Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
MedComm, Volume 7, Issue 9, September 2026.The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song +4 more
wiley +1 more source
DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy
MedComm, Volume 7, Issue 9, September 2026.This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu +6 more
wiley +1 more source
LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes. [PDF]
Cell Death DisKeller J +12 more
europepmc +1 more source
Tissue‐Resident Macrophage in Inflammation and Cancer
MedComm, Volume 7, Issue 9, September 2026.Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang +13 more
wiley +1 more source
Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 3, September 2026.Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley +1 more source
Correction: Gasdermin E benefits CD8 + T cell mediated anti-immunity through mitochondrial damage to activate cGAS-STING-interferonβ axis in colorectal cancer. [PDF]
Biomark ResLuo B +5 more
europepmc +1 more source