Results 171 to 180 of about 12,681 (203)

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

2022
Summary Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin (GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their roles in the central nervous system (CNS) are not well understood.
Dylan V Neel, Himanish Basu, Georgia Gunner, Matthew D Bergstresser, Richard M. Giadone, Haeji Chung, Rui Miao, Vicky Chou, Eliza M. Brody, Xin Jiang, Edward B. Lee, Christine Marques, Aaron Held, Brian Wainger, Clotilde Lagier-Tourenne, Yong-Jie Zhang, Leonard Petrucelli, Tracy L. Young-Pearse, Alice S Chen-Plotkin, Lee L. Rubin, Judy Lieberman, Isaac M Chiu   +21 more
openaire   +1 more source

Enhanced Gasdermin-E-mediated Pyroptosis in Alzheimer’s Disease

Neuroscience
Amyloid β protein (Aβ) is a critical factor in the pathogenesis of Alzheimer's disease (AD). Aβ induces apoptosis, and gasdermin-E (GSDME) expression can switch apoptosis to pyroptosis. In this study, we demonstrated that GSDME was highly expressed in the hippocampus of APP23/PS45 mouse models compared to that in age-matched wild-type mice.
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song   +8 more
openaire   +2 more sources

MACC1 and Gasdermin-E (GSDME) regulate the resistance of colorectal cancer cells to irinotecan

Biochemical and Biophysical Research Communications, 2023
Metastasis-associated in colon cancer 1 (MACC1) is an oncogene associated with the progression and metastasis of many solid cancer entities. High expression of MACC1 is found in colorectal cancer (CRC) tissues. So far, the role of MACC1 in CRC cell pyroptosis and resistance to irinotecan is unclear.
Ming-Zhen, Cheng, Bo-Bo, Yang, Ze-Tao, Zhan, Si-Min, Lin, Zhe-Ping, Fang, Yi, Gao, Wei-Jie, Zhou   +6 more
openaire   +2 more sources

Improved antitumor immunity of chemotherapy in OSCC treatment by Gasdermin-E mediated pyroptosis

Apoptosis, 2022
Oral squamous cell carcinoma (OSCC) is a malignant tumor with high mortality and poor prognosis. Many OSCC patients have low response rate to current treatments including immunotherapies largely due to the immune-suppressive tumor microenvironment (TME). Chemotherapy could induce immunogenic cell death (ICD), a type of cell death such as pyroptosis and
Mei Zi, Chen Xingyu, Chen Yang, Su Xiaodong, Lv Shixian, Wei Shicheng   +5 more
openaire   +2 more sources

Insight into the structure, function and the tumor suppression effect of gasdermin E

Biochemical Pharmacology
Gasdermin E (GSDME), which is also known as DFNA5, was first identified as a deafness-related gene that is expressed in cochlear hair cells, and mutation of this gene causes autosomal dominant neurogenic hearing loss. Later studies revealed that GSDME is mostly expressed in the kidney, placenta, muscle and brain cells, but it is expressed at low levels
Yuge, Long, Xiaoyuan, Jia, Liang, Chu
openaire   +2 more sources

Gasdermin E shields PDAC

Nature Reviews Cancer, 2022
openaire   +2 more sources

Gasdermin E as a potential target and biomarker for CRISPR-Cas9-based cancer therapy

Biochemical Pharmacology
Gasdermin E (GSDME), a protein pivotal in mediating pyroptosis, has gained significant attention due to its role in cancer pathogenesis and its potential as a therapeutic target. The advent of CRISPR-Cas9, a precise genome editing tool, has revolutionized cancer therapy by enabling the manipulation of GSDME expression and function. This review explores
Mojtaba Tarin, Amir Sh. Saljooghi
openaire   +2 more sources

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Cell, 2021
Iva Hafner Bratković, John Doench, Martin W Lafleur   +2 more
exaly  

Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine

Cell, 2023
Zheng Wei, Richard Flavell
exaly  

Pyroptosis and the cellular consequences of gasdermin pores

Seminars in Immunology, 2023
Susan L Fink
exaly