Results 81 to 90 of about 1,758,994 (174)

The evolving role of positron emission tomography in precision prostate cancer biopsy

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
Prostate biopsy plays a pivotal role in the detection and characterization of prostate cancer. PSMA PET‐targeted biopsy represents a significant advancement in prostate cancer diagnostics, offering higher sensitivity, specificity and accuracy in detecting clinically significant lesions compared to traditional methods. PSMA PET, when combined with mpMRI,
Alessio Imperiale, Valentina Berti, Roberto Luigi Cazzato, Darejan Mamulashvili Bessac, Alice Ressault, Luca Vaggelli, Mehdi Helali, Camilo Garcia, Hervé Lang, Desirée Deandreis, Luc Mertz, Afshin Gangi   +11 more
wiley   +1 more source

177Lu Radiolabeling of RM26 Modified with Oligo-Phenylene-Ethynylene and its Cellular Internalization

Journal of Isotopes, 2022
Gastrin releasing peptide receptor (GRPR) is overexpressed in various tumors, and these GRPR-positive tumors have successfully and widely been targeted with GRPR antagonists.
LIAO Wei;FU Huaxia;LI Xiangyu;KAN Wentao;YANG Xia;WANG Jing;ZHAO Peng;ZHUO Liangang;YANG Yuchuan;WEI Hongyuan
doaj  

Benzochalcogenodiazoles, Synthesis, and Applications in Medicinal Chemistry and Photomedicine

European Journal of Organic Chemistry, Volume 28, Issue 23, June 23, 2025.
Benzochalcogenodiazoles (BXD) including benzoxadiazoles, benzothiadiazoles, and benzoselenadiazoles are initially mainly designed for optoelectronic materials as electron‐deficient cores. Nevertheless, they are now extending their application to biology.
Jean‐Elie Zheng, Xavier Franck, Thibault Gallavardin   +2 more
wiley   +1 more source

Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

Pharmaceutics, 2019
Gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) are overexpressed in most prostate cancers. GRPR expression is higher in early stages while PSMA expression increases with progression.
Ayman Abouzayed, Cheng-Bin Yim, Bogdan Mitran, Sara S. Rinne, Vladimir Tolmachev, Mats Larhed, Ulrika Rosenström, Anna Orlova   +7 more
doaj   +1 more source

How Gastrin-Releasing Peptide Opens the Spinal Gate for Itch [PDF]

, 2019
Spinal transmission of pruritoceptive (itch) signals requires transneuronal signaling by gastrin-releasing peptide (GRP) produced by a subpopulation of dorsal horn excitatory interneurons.
Albisetti, Gioele W, Johannssen, Helge C, Santello, Mirko, Zeilhofer, Hanns Ulrich; https://orcid.org/, Sivakumar, Nandhini, Wildner, Hendrik, Pagani, Martina   +6 more
core   +1 more source

Gastrin-releasing peptide receptor-targeted gadolinium oxide-based multifunctional nanoparticles for dual magnetic resonance/fluorescent molecular imaging of prostate cancer

, 2017
Danting Cui,1 Xiaodan Lu,1 Chenggong Yan,1 Xiang Liu,1 Meirong Hou,1 Qi Xia,2 Yikai Xu,1 Ruiyuan Liu2,3 1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China; 2School of ...
Liu X, Liu RY, Yan CG, Lu XD, Xia Q, Xu YK, Hou MR, Cui DT   +7 more
core  

Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]

, 1994
The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Strasburger, Christian J., Renner, U., Müller, O., Stalla, G., Brockmeier, S., Schopohl, Jochen, Strasburger, C., Müller, Otto-Albrecht, Schopohl, J., Strasburger, C. J., Werder, K., Lange, M., Werder, K. von, Stalla, G. K., Müller, O. A.   +14 more
core   +1 more source

Chemotherapy alters radiosensitivity and GRPR expression of prostate and breast cancer cells

EJNMMI Research
Background Gastrin releasing peptide receptor (GRPR)-targeting radiotracers have been studied (pre)-clinically with promising results. Patients eligible for this treatment are likely to have undergone prior treatments with other anti-cancer agents ...
Tyrillshall S.T. Damiana, Lilian van den Brink, Lisette W. de Kreij-de Bruin, Debra C. Stuurman, Corrina M.A. de Ridder, Simone U. Dalm   +5 more
doaj   +1 more source

Positron emission tomography (PET) imaging of prostate cancer with a gastrin releasing peptide receptor antagonist - from mice to men [PDF]

, 2014
UNLABELLED Ex vivo studies have shown that the gastrin releasing peptide receptor (GRPr) is overexpressed on almost all primary prostate cancers, making it a promising target for prostate cancer imaging and targeted radiotherapy.
Meyer, Philipp T, Mansi, Rosalba, Reubi, Jean Claude, Schultze-Seemann, Wolfgang, Grosu, Anca-Ligia, Mäcke, Helmut R., Wieser, Gesche, Dumont-Walter, Rebecca A., Maecke, Helmut R, Reubi, Jean-Claude, Dumont-Walter, Rebecca A, Grosu, Anca L, Weber, Wolfgang A., Weber, Wolfgang A, Meyer, Philipp Tobias   +14 more
core   +2 more sources

Comparison of the binding of the gastrin-releasing peptide receptor (GRP-R) antagonist 68Ga-RM2 and 18F-FDG in breast cancer samples.

PLoS ONE, 2019
The Gastrin-Releasing Peptide Receptor (GRPR) is over-expressed in estrogen receptor (ER) positive breast tumors and related metastatic lymph nodes offering the opportunity of imaging and therapy of luminal tumors. 68Ga-RM2 binding and 18F-FDG binding in
Clément Morgat, Romain Schollhammer, Gaétan Macgrogan, Nicole Barthe, Valérie Vélasco, Delphine Vimont, Anne-Laure Cazeau, Philippe Fernandez, Elif Hindié   +8 more
doaj   +1 more source