Results 61 to 70 of about 1,758,994 (174)

Profiling gastrin-releasing peptide receptor in prostate tissues: Clinical implications and molecular correlates

, 2011
BACKGROUND: The gastrin-releasing peptide receptor (GRPR) has emerged as an attractive target for both therapeutic and diagnostic appliances, but has only insufficiently been characterized in the human prostate so far. The aim of this study is to profile
Hany, T F; https://orcid.org/, Beer, Marc, Hany, Thomas F, Wild, P J, Josefine Gerhardt, Matteo Montani, Hermanns, Thomas, Peter J. Wild, Glen Kristiansen, Kristiansen, G, Müntener, Michael, Marc Beer, Hermanns, T, Montani, Matteo, Kristiansen, Glen, Wild, Peter J, Beer, M, Michael Müntener, Gerhardt, Josefine, Gerhardt, J, Thomas F. Hany, Thomas Hermanns, Müntener, M, Montani, M   +23 more
core   +1 more source

Revisiting the gastrin-releasing peptide/bombesin system: A reverse-evolutionary study considering Xenopus

, 2020
The expression levels of gastrin-releasing peptide (GRP) and GRP receptor (GRPR) mRNA in Xenopus central nervous system were measured by the real-time quantitative PCR.
Hamada, M
core   +2 more sources

Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

Nature Communications
Itch is a common side effect of opioid analgesics. The specific neurons mediating opioid-induced itch are still debated, and the mechanistic neuronal circuits remain elusive.
Qian Zeng, Yitong Li, Yifei Wu, Jiawei Wu, Kangtai Xu, Yiming Chen, Yunfei Rao, Nan Li, Yuhui Luo, Changyu Jiang, Chaoran Wu, Zilong Wang   +11 more
doaj   +1 more source

GRP Receptor Regulates Depression Behavior via Interaction With 5-HT2a Receptor

Frontiers in Psychiatry, 2020
ObjectiveAccumulating evidences indicate that gastrin-releasing peptide receptor (GRPR) may contribute to the pathophysiology of depression. However, the mechanism of the involvement of GRPR in the progression of depression remains unclear.
Dan Xiang, Huiling Wang, Siqi Sun, Lihua Yao, Ruiting Li, Xiaofen Zong, Gaohua Wang, Zhongchun Liu   +7 more
doaj   +1 more source

PSMA PET‐directed radiotherapy for prostate cancer: From precision planning to future innovations

VIEW, Volume 7, Issue 1, February 2026.
Prostate‐specific membrane antigen (PSMA) positron emission tomography (PET) imaging enables highly sensitive detection of prostate cancer recurrence and precise lesion mapping. This review summarizes current evidence and emerging applications of PSMA PET in radiotherapy, including diagnostic staging, target delineation, adaptive planning, and outcome ...
Wenpeng Huang, Jessica C. Hsu, Ruobing Li, Kexin Lan, Xin Qi, Yuchun Wei, Weibo Cai, Hongzhen Li   +7 more
wiley   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours

, 2004
Aims: To establish whether gastrin releasing peptide (GRP) and the GRP receptor (GRPR) are expressed together in gastrointestinal carcinoid tumours. Methods: Twenty six carcinoid tumours from the stomach, small intestine, appendix, and colorectum were ...
Scott, N., Millward, E., Preston, S. R., Coletta, P. L., Cartwright, E. J.; id_orcid   +4 more
core   +1 more source

Downregulation of the NPY-Y1R system in Grpr neurons results in mechanical and chemical hyperknesis in chronic itch

Neurobiology of Disease
Chronic itch remains a clinically challenging condition with limited therapeutic efficacy, posing a significant burden on patients' quality of life. Despite its prevalence, the underlying neural mechanisms remain poorly understood.
Danqing Dai, Zongxi Li, Tiantian Zhao, Zhen Li, Yali Tang, Xiujuan Li, Xiao-Fei Gao, Lize Xiong   +7 more
doaj   +1 more source

Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention

MedComm, Volume 7, Issue 1, January 2026.
The review manuscript examines the molecular pathogenesis, screening, prevention advances, and evolving targeted therapies in breast cancer. It highlights the integration of AI and multiomics for precision prevention and personalized treatment, pointing toward future directions in equitable cancer care.
Huijun Lei, Jinzhen Fu, Wei Gu, Hongjin Qiao, Huixue Guo, Zijian Chen, San Ming Wang, Tianhui Chen   +7 more
wiley   +1 more source

Spinal Cord Interneurons Expressing the Gastrin-Releasing Peptide Receptor Convey Itch Through VGLUT2-Mediated Signaling

, 2017
Itch is a sensation that promotes the desire to scratch, which can be evoked by mechanical and chemical stimuli. In the spinal cord, neurons expressing the gastrin-releasing peptide receptor (GRPR) have been identified as specific mediators of itch ...
Sharn Perry, Joey Lau, Lagerström, Malin C., Lau, Joey,, Freitag, Fabio B., Edda Blümel, Fabio B. Freitag, Marina C.M. Franck, Lagerström, Malin C.,, Perry, Sharn,, Franck, Marina C.M.,, Aresh, Bejan, Bejan Aresh, Aresh, Bejan,, Blümel, Edda, Malin C. Lagerström, Perry, Sharn, Lau, Joey, Freitag, Fabio B.,, Franck, Marina C.M., Blümel, Edda,   +20 more
core   +1 more source