Results 41 to 50 of about 1,758,994 (174)

Gastrin releasing peptide receptor targeted nano-graphene oxide for near-infrared fluorescence imaging of oral squamous cell carcinoma

Scientific Reports, 2020
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor that occurs in the oral mucosa. Pathological biopsy is still the current gold standard for OSCC diagnosis; however, some drawbacks need to be overcome.
Ran Li, Ruifang Gao, Yimei Wang, Zhuanzhuan Liu, Hang Xu, Ailin Duan, Fang Zhang, Lixin Ma   +7 more
doaj   +1 more source

Heterodimeric Radiotracer Targeting PSMA and GRPR for Imaging of Prostate Cancer—Optimization of the Affinity towards PSMA by Linker Modification in Murine Model

Pharmaceutics, 2020
Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) are promising targets for molecular imaging of prostate cancer (PCa) lesions.
Fanny Lundmark, Ayman Abouzayed, Bogdan Mitran, Sara S. Rinne, Zohreh Varasteh, Mats Larhed, Vladimir Tolmachev, Ulrika Rosenström, Anna Orlova   +8 more
doaj   +1 more source

Radionuclide GRPR imaging in malignant pathology of the mammary and prostate glands: clinical experience

Бюллетень сибирской медицины
In this lecture, we presented current clinical studies on targeted radionuclide imaging of breast and prostate tumors with overexpression of the gastrin-releasing peptide receptor (GRPR). The gastrin-releasing peptide receptor is a transmembrane receptor,
O. D. Bragina, A. G. Ivanova, E. A. Usynin   +2 more
doaj   +1 more source

Targeting rectal cancer using fluorescent nanoparticles conjugated to a novel GRPR-Binding peptide for tumor imaging applications

Materials & Design
Surgical treatment of rectal cancer is difficult due to anatomical complexity. To improve tumor resection, fluorescence-guided surgery (FGS) has been developed using near-infrared fluorescence (NIRF, approximately 800 nm) and a dedicated camera system ...
Somayeh Rezaei, Mark Fonteyne, Luis J. Cruz, Nada Badr, Ajinkya Manelkar, Mahin Saberi, Ronald L.P. van Vlierberghe, Alexander L. Vahrmeijer, Christina Eich, Fernando Albericio, Louise. van der Weerd, Peter J.K. Kuppen   +11 more
doaj   +1 more source

Precision Theranostics in Nuclear Medicine Targeting Gastrin-Releasing Peptide Receptor

Xiehe Yixue Zazhi
The gastrin-releasing peptide receptor (GRPR) is highly expressed in various malignant tumors (e.g., glioblastoma, prostate cancer, and breast cancer) and has emerged as an important molecular target for precision cancer diagnosis and therapy.
WANG Rongxi, ZHU Zhaohui, CHEN Xiaoyuan
doaj   +1 more source

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target

Frontiers in Endocrinology, 2012
Neuropeptides acting on specific cell membrane receptors of the G protein-coupled receptor (GPCR) superfamily regulate a range of important aspects of nervous and neuroendocrine function.
Rafael eRoesler, Gilberto eSchwartsmann
doaj   +1 more source

Role of GRPR in Acupuncture Intervention in the “Itch-scratch Vicious Cycle” Spinal Circuit of Chronic Pruritus

Chinese Medicine, 2023
Many previous studies have shown the potential antipruritic effect of acupuncture. This paper reviews the antipruritic mechanisms of acupuncture according to these aspects: sample characteristics, detail of intervention, and effects evaluation.
Jia-jia Liu, Xuemei Li, Jing Guo, Shuguang Yu, Sha Yang   +4 more
doaj   +1 more source

New Gastrin Releasing Peptide Receptor-Directed [^99mTc]Demobesin 1 Mimics: Synthesis and Comparative Evaluation [PDF]

, 2018
We have previously reported on the gastrin releasing peptide receptor (GRPR) antagonist [99mTc]1, ([99mTc]­demobesin 1, 99mTc-[N4′-diglycolate-dPhe6,Leu-NHEt13]­BBN­(6–13)).
Jean-Claude Reubi, Mansi, Rosalba, David Charalambidis (4972360), Werner Sallegger, Jean-Claude Reubi (2509744), David Charalambidis, Melpomeni Fani, Nock, Berthold A, Guillaume P. Nicolas (2086789), Waser, Beatrice, Eleni Ketani, Reubi, Jean-Claude, Eleni Ketani (4972363), Guillaume P. Nicolas, Werner Sallegger (4972369), Fani, Melpomeni, Beatrice Waser, Berthold A. Nock, Charalambidis, David, Sallegger, Werner, Anastasia Nikolopoulou, Berthold A. Nock (3022125), Beatrice Waser (307519), Nicolas, Guillaume P, Nikolopoulou, Anastasia, Rosalba Mansi (1583038), Theodosia Maina (2961291), Theodosia Maina, Maina, Theodosia, Rosalba Mansi, Melpomeni Fani (2086792), Anastasia Nikolopoulou (4972366), Ketani, Eleni   +32 more
core   +1 more source

66Ga-PET-imaging of GRPR-expression in prostate cancer: production and characterization of [66Ga]Ga-NOTA-PEG2-RM26

Scientific Reports, 2021
Molecular imaging of the gastrin-releasing peptide receptor (GRPR) could improve patient management in prostate cancer. This study aimed to produce gallium-66 (T½ = 9.5 h) suitable for radiolabeling, and investigate the imaging properties of gallium-66 ...
Sara S. Rinne, Ayman Abouzayed, Katherine Gagnon, Vladimir Tolmachev, Anna Orlova   +4 more
doaj   +1 more source

Spinal Mechanisms of Testosterone Involved in Itch Regulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Testosterone serves as an endogenous anti‐pruritic hormone underlying sex‐dependent itch differences. In the spinal dorsal horn, testosterone binds androgen receptors on GABAergic interneurons to enhance GABA release, suppressing GRPR+ − pruriceptive neurons through GABAA receptors and alleviating acute/chronic itch alongside itch‐comorbid anxiety ...
Luying Chen, Xiaodong Wang, Lu Cheng, Pengtao Li, Zhenyu Wu, Hui Li   +5 more
wiley   +1 more source