Dementia & Neuropsychologia, 2007 Increasing evidence indicates that bombesin (BB)-like peptides (BLPs), such as the gastrin-releasing peptide (GRP) and its receptor (GRPR), might play a role in neurological and psychiatric disorders.
Rafael Roesler +2 more
doaj +3 more sources
The Gastrin-Releasing Peptide Receptor (GRPR) in the Spinal Cord as a Novel Pharmacological Target. [PDF]
Curr Neuropharmacol, 2014 Gastrin-releasing peptide (GRP) is a mammalian neuropeptide that acts through the G protein-coupled receptor, GRP receptor (GRPR). Increasing evidence indicates that GRPR-mediated signaling in the central nervous system plays an important role in many physiological processes in mammals. Additionally, we have recently reported that the GRP system within
Takanami K, Sakamoto H.
europepmc +4 more sources
A preclinical study on the influence of linkers in [68Ga]Ga-NOTA-X-RM26 radiotracers for PET imaging of GRPR expression [PDF]
EJNMMI ResearchBackground Gastrin-releasing peptide receptor (GRPR) is overexpressed in several cancers, including prostate and breast, making it an attractive target for radiopharmaceutical development.
Esther Olaniran Håkansson +9 more
doaj +2 more sources
Gastrin-releasing peptide receptor expression in gastrointestinal stromal tumours
ESMO Gastrointestinal OncologyBackground: There are limited treatment options for patients with advanced or metastatic gastrointestinal stromal tumours (GISTs) that lack mutations targetable by tyrosine kinase inhibitors (TKIs) or that have developed resistance to TKIs.
M. Berndsen +6 more
doaj +2 more sources
Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. [PDF]
, 1992 Helicobacter pylori increases gastrin release in duodenal ulcer patients. This may be through disruption or changes in the mucus layer affecting the access of luminal stimulants to gastrin releasing cells.
Ghosh, P +6 more
core +4 more sources
Bioorthogonal Chemistry Approach for the Theranostics of GRPR-Expressing Cancers
Pharmaceutics, 2022 Several gastrin-releasing peptide receptor (GRPR) antagonists with improved in vivo behavior have been recently developed and tested in the clinic. However, despite the generally mild side effects of peptide receptor radionuclide therapy (PRRT), toxicity
Alice D’Onofrio +9 more
doaj +1 more source
GRPR-targeting radiotheranostics for breast cancer management
Frontiers in Medicine, 2023 Breast Cancer (BC) is the most common cancer worldwide and, despite the advancements made toward early diagnosis and novel treatments, there is an urgent need to reduce its mortality.
Alice D’Onofrio +4 more
doaj +1 more source
Pharmaceuticals, 2021 In the context of hybrid multimodal imaging agents for gastrin releasing peptide receptor (GRPR) targeting, a correlation between the net charge and the receptor affinity of the agents was recently found.
Marco Maspero +6 more
doaj +1 more source
Engineered antibody and neuropeptide mediated radionuclide targeting in prostate cancer [PDF]
, 2010 PhDProstate cancer (PC) is the most common cancer type in men in the western world and to date no definitive stratergy to image PC is avaliable. This thesis explores the possibility of using Prostate Specific Membrane Antigen (PSMA) and Gastrin Releasing
Kashani, Roxana M. G.
core +4 more sources
Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice
Cell Reports, 2018 Summary: Chronic itch or pruritus is a debilitating disorder that is refractory to conventional anti-histamine treatment. Kappa opioid receptor (KOR) agonists have been used to treat chronic itch, but the underlying mechanism remains elusive.
Admire Munanairi +20 more
doaj +1 more source