Results 1 to 10 of about 1,943 (121)

Gastrin-releasing peptide receptor (GRPR) as a novel biomarker and therapeutic target in prostate cancer [PDF]

Annals of Medicine
Aim: This comprehensive review aims to explore the potential applications of Gastrin-releasing peptide receptor (GRPR) in the diagnosis and treatment of prostate cancer.
Honghu Zhang, Lin Qi, Yi Cai, Xiaomei Gao   +3 more
doaj   +4 more sources

Stability Evaluation and Stabilization of a Gastrin-Releasing Peptide Receptor (GRPR) Targeting Imaging Pharmaceutical [PDF]

Molecules, 2019
The prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptor (GRPR) are identified as important targets on prostate cancer. Receptor-targeting radiolabeled imaging pharmaceuticals with high affinity and specificity are useful in ...
Arijit Ghosh, Karen Woolum, Shankaran Kothandaraman, Michael F. Tweedle, Krishan Kumar   +4 more
doaj   +4 more sources

Supraspinal Circuit Mechanisms Underlying Itch Processing. [PDF]

CNS Neurosci Ther
Peripheral pruriceptive signals ascend from the spinal cord to the brainstem, thalamus, and cortex to encode the sensory features of itch. Parallel projections to limbic and basal ganglia circuits mediate affective and motivational components, including aversion and scratching urge.
Luo Y, Tang HD, Liao P, Jiang R.
europepmc   +2 more sources

GRPR-induced FAM135A expression promote perineural invasion in prostate cancer [PDF]

Molecular Cancer
Perineural invasion (PNI) is an independent adverse prognostic marker for prostate cancer (PCa) metastasis. Gastrin releasing peptide receptor (GRPR) targeted imaging and therapeutics have entered clinical trials, while its role in PCa perineural ...
Ning Zhang, Xiaohao Ruan, Siteng Chen, Ruofan Shi, Xiaoqun Yang, Yongle Zhan, Stacia Chun, Chi Yao, Salida Ali, Brian Sze-Ho Ho, Ada Tsui-Lin Ng, Richard KY Lo, Rong Na   +12 more
doaj   +2 more sources

The gastrin-releasing peptide receptor in oncology: a comprehensive review of recent advances in targeted radionuclide theranostics [PDF]

Frontiers in Oncology
The gastrin-releasing peptide receptor (GRPR) is aberrantly expressed in several malignancies, including prostate cancer, breast cancer, lung cancer, and gastrointestinal stromal tumors, making it an important target for molecular imaging and targeted ...
YunLong Yang, YunLong Yang, Jiang Fu, ShengJie Tang, Tao Liu, HaiYang Hu, HaiYang Guo, Long Wen, Long Wen, Yang Yang, Yang Yang, ChengKuan Liu, ChengKuan Liu, GuiYan Yi, Li Yu, HaiNing Zhou, HaiNing Zhou, HaiNing Zhou, HaiNing Zhou   +18 more
doaj   +2 more sources

Emerging agents for boron neutron capture therapy: Biomolecular carriers paving the way for precision radiotherapy. [PDF]

Precis Radiat Oncol
Boron neutron capture therapy (BNCT) requires key non‐negotiable technical criteria: megadose administration, precise tumor‐specific targeting, favorable biocompatibility, and sustained tumor retention. Overcoming these interconnected challenges fundamentally depends on biomolecular carriers, which are critical for translating the therapeutic potential
Chen C, Yang M, Wang J, Zhang L, Huang S, Xu X, Liu Y.   +6 more
europepmc   +2 more sources

The gastrin-releasing peptide receptor as a potential biomarker for squamous cell carcinoma [PDF]

Scientific Reports
The gastrin-releasing peptide receptor (GRPR) is expressed across multiple human cancer types, including head and neck tumors, and has also been detected in the oral mucosa of patients bearing head and neck neoplasms.
Danielly Brufatto Olguins, Júlia Caroline Marcolin, Mariane da Cunha Jaeger, Manoela Domingues Martins, Luis Fernando da Rosa Rivero, Gilberto Schwartsmann, Rafael Roesler, Marcelo Gerardin Poirot Land, Martina Lichtenfels, Caroline Brunetto de Farias   +9 more
doaj   +2 more sources

Potential Targets and Biomarkers of Radionuclide Therapy in Breast Cancer. [PDF]

Cancer Innov
Potential biomarkers for the development of targeted radionuclide therapy that can be employed in the treatment of breast cancer have been summarised in the review. They include receptor markers of ER, PR and HER2, as well as other markers of Trop2, PD‐1, EGFR, GRPR and PSMA.
Tan Y, Zeng C, Wang J, Ma F.
europepmc   +2 more sources

In vitro gastrin-releasing peptide response in chicken ovarian follicles [PDF]

Poultry Science
The gastrin-releasing peptide (GRP) is reported to be mainly produced by the pituitary in chickens, with its receptor (GRPR) highly expressed in the ovaries, indicating its regulatory role in ovarian function. Present study aims to verify the role of GRP
Chunheng Mo, Can Lv, Guoqiang Zhu, Jiannan Zhang, Yuanyou Li, Yajun Wang, Juan Li   +6 more
doaj   +2 more sources

How gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin expression reflect reorganization features of tumors after hyperthermia treatments [PDF]

Scientific Reports, 2017
The outcome of tumor treatment via hyperthermia in the clinic has been reported to be heterogeneous. Here, we assessed how the presence of gastrin-releasing peptide receptor (GRPR) and αvβ3 integrin together with the morphology of the vascularization ...
Sandra Hallasch, Sindy Frick, Maximilian Jung, Ingrid Hilger   +3 more
doaj   +2 more sources