Results 31 to 40 of about 1,758,994 (174)

A spinal neural circuitry for converting touch to itch sensation

Nature Communications, 2020
Light touch can sometimes induce unpleasant itch sensation but the neural correlates of this conversion are not well studied. Here, the authors provide evidence that Tac2 expressing spinal interneurons are connected to gastrin-releasing peptide receptor (
Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen   +11 more
doaj   +1 more source

Copper-67-Labeled Bombesin Peptide for Targeted Radionuclide Therapy of Prostate Cancer

Pharmaceuticals, 2022
The gastrin-releasing peptide receptor (GRPR) is a promising molecular target for imaging and therapy of prostate cancer using bombesin peptides that bind to the receptor with high affinity. Targeted copper theranostics (TCTs) using copper radionuclides,
Truc T. Huynh, Ellen M. van Dam, Sreeja Sreekumar, Cedric Mpoy, Benjamin J. Blyth, Fenella Muntz, Matthew J. Harris, Buck E. Rogers   +7 more
doaj   +1 more source

Bombesin receptor-targeted liposomes for enhanced delivery to lung cancer cells

Beilstein Journal of Nanotechnology, 2019
Background: Gastrin-releasing peptide is a member of the bombesin family of peptides. Its cognate receptor, gastrin releasing peptide receptor (GRPR), is widely expressed in cancers of the lung, pancreas and ovaries. Gastrin releasing peptide (GRP) is an
Mohammad J. Akbar, Pâmela C. Lukasewicz Ferreira, Melania Giorgetti, Leanne Stokes, Christopher J. Morris   +4 more
doaj   +1 more source

Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP) [PDF]

, 2009
Background: Pro-gastrin releasing peptide ( ProGRP) concentrations in blood play an important role in the diagnosis and treatment of patients with small cell lung cancer (SCLC).
Patil, Rahul D., Dowell, Barry L., Iizuka, Masayuki, Yamaguchi, Ken, Chan, Sabrina S., Kinukawa, Hideki, Chan, Daniel W., Hofmann, Karin, Stieber, Petra, Sakurai, Yousuke, Yoshimura, Toru, Matsuoka, Yoshiharu, Sokoll, Lori, Scheuer, Cornelia, Saegusa, Haruhisa, Fujita, Kenju, Beligere, Gangamani S., Elliott, Debra   +17 more
core   +1 more source

Characterization of the expression of gastrin‐releasing peptide and its receptor in the trigeminal and spinal somatosensory systems of Japanese macaque monkeys: Insight into humans

, 2022
Gastrin-releasing peptide (GRP) and its receptor (GRPR) have been identified as itch mediators in the spinal and trigeminal somatosensory systems in rodents.
Oti Takumi, さかもと ひろたか, Tsutsui Naoaki, さかもと たつや, Ueda Yasumasa, おち たくみ, Sakamoto Hirotaka, Kobayashi Yasuhisa, 小林 靖尚, つつい なおあき, Carstens Earl, はせがわ こうき, 越智 拓海, たかなみ けいこ, 高浪 景子, 筒井 直昭, 坂本 浩隆, Sakamoto Tatsuya, Ito Takashi, こばやし やすひさ, Takanami Keiko, 上田 康雅, 1000070578830, 坂本 竜哉, 長谷川 功紀, うえだ やすまさ, Hasegawa Koki   +26 more
core   +1 more source

A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior

Cell Reports, 2022
Summary: Contagious itch behavior informs conspecifics of adverse environment and is crucial for the survival of social animals. Gastrin-releasing peptide (GRP) and its receptor (GRPR) in the suprachiasmatic nucleus (SCN) of the hypothalamus mediates ...
Fang Gao, Jun Ma, Yao-Qing Yu, Xiao-Fei Gao, Yang Bai, Yi Sun, Juan Liu, Xianyu Liu, Devin M. Barry, Steven Wilhelm, Tyler Piccinni-Ash, Na Wang, Dongyang Liu, Rachel A. Ross, Yan Hao, Xu Huang, Jin-Jing Jia, Qianyi Yang, Hao Zheng, Johan van Nispen, Jun Chen, Hui Li, Jiayi Zhang, Yun-Qing Li, Zhou-Feng Chen   +24 more
doaj   +1 more source

Prospects of Targeting the Gastrin Releasing Peptide Receptor and Somatostatin Receptor 2 for Nuclear Imaging and Therapy in Metastatic Breast Cancer. [PDF]

PLoS ONE, 2017
The gastrin releasing peptide receptor (GRPR) and the somatostatin receptor 2 (SSTR2) are overexpressed on primary breast cancer (BC), making them ideal candidates for receptor-mediated nuclear imaging and therapy.
Simone U Dalm, Willemijne A M E Schrijver, Anieta M Sieuwerts, Maxime P Look, Angelique C J Ziel-van der Made, Vanja de Weerd, John W Martens, Paul J van Diest, Marion de Jong, Carolien H M van Deurzen   +9 more
doaj   +1 more source

Gastrin-Releasing Peptide Receptor in Low Grade Prostate Cancer: Can It Be a Better Predictor Than Prostate-Specific Membrane Antigen?

Frontiers in Oncology, 2021
The aim of the present study was to evaluate whether prostate cancer (PC) patients can be accurately classified on the bases of tissue expression of gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA).
Pinuccia Faviana, Laura Boldrini, Paola Anna Erba, Iosè Di Stefano, Francesca Manassero, Riccardo Bartoletti, Luca Galli, Carlo Gentile, Massimo Bardi   +8 more
doaj   +1 more source

Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy [PDF]

, 2023
Gastrin releasing peptide receptor (GRPR), a member of the bombesin (BBN) G protein-coupled receptors, is aberrantly overexpressed in several malignant tumors, including those of the breast, prostate, pancreas, lung, and central nervous system ...
Zhan, Yuting, Ren, Lu, Chen, Anqi, Chen, Zhou-Feng, Zhang, Haitao, Shuman Peng, Dongqi Zhang, Zhang, Dongqi, Lu Ren, Zhou-Feng Chen, Anqi Chen, Haitao Zhang, Peng, Shuman, Yuting Zhan   +13 more
core   +1 more source

Phase I Trial of [99mTc]Tc-maSSS-PEG2-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors

Cancers, 2023
The gastrin-releasing peptide receptor (GRPR) is overexpressed in prostate cancer (PCa) and in hormone-driven breast cancer (BCa). The aim of this phase I clinical trial was to evaluate safety, biodistribution, and dosimetry after the administration of the recently developed GRPR-targeting antagonistic bombesin analogue [99mTc]Tc-maSSS-PEG2-RM26 in PCa
Vladimir Chernov, Anastasiya Rybina, Roman Zelchan, Anna Medvedeva, Olga Bragina, Nadejda Lushnikova, Artem Doroshenko, Evgeniy Usynin, Liubov Tashireva, Sergey Vtorushin, Ayman Abouzayed, Sara S. Rinne, Jens Sörensen, Vladimir Tolmachev, Anna Orlova   +14 more
openaire   +3 more sources