Results 51 to 60 of about 1,758,994 (174)

Evolution of bombesin conjugates for targeted PET imaging of tumors. [PDF]

PLoS ONE, 2012
Bombesin receptors are under intense investigation as molecular targets since they are overexpressed in several prevalent solid tumors. We rationally designed and synthesized a series of modified bombesin (BN) peptide analogs to study the influence of ...
Hanwen Zhang, Keelara Abiraj, Daniel L J Thorek, Beatrice Waser, Peter M Smith-Jones, Michael Honer, Jean Claude Reubi, Helmut R Maecke   +7 more
doaj   +1 more source

Human gastrin- releasing peptide receptor expression in women with uterine cervix cancer

Frontiers in Oncology, 2023
Introduction212Pb-DOTAM-GRPR1 is a pharmaceutical radioimmunoconjugate consisiting of an α-particle-emitting radionuclide lead-212 (212Pb), a metal chelator DOTAM (1,4,7,10-tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane), and a gastrin ...
Charles A. Kunos, Denise Fabian, Dana Napier, Mark S. Stonecypher, Ravyn M. Duncan, Jason Hurt   +5 more
doaj   +1 more source

Peptide‐based responsive molecular fluorescent probes for precision oncology

Responsive Materials, Volume 4, Issue 3, August 2026.
Peptide‐based responsive fluorescent probes have emerged as adaptive functional materials for precision tumor theranostics, combining tumor‐selective recognition, programmable stimulus responsiveness, and modular tunability. They enable high‐contrast imaging, intraoperative guidance, real‐time monitoring, and multimodal applications, while next ...
Xing Wang, Wen Liu, Jiahao Zhang, Wanqi Wang, Zhicheng Jin, Yuqi Tang, Quan Li   +6 more
wiley   +1 more source

Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors

, 2011
Bombesin receptors are overexpressed on a variety of human tumors. In particular, the gastrin-releasing peptide receptor (GRPr) has been identified on prostate and breast cancers and on gastrointestinal stromal tumors.
Keelara Abiraj, Forrer, Flavio, Mansi, Rosalba, Reubi, Jean Claude, Cescato, Renzo, Mäcke, Helmut R., Melpomeni Fani, Guillaume Nicolas, Tamma, Maria Luisa, Tamma, Maria-Luisa, Helmut R. Maecke, Maecke, Helmut R, Reubi, Jean-Claude, Flavio Forrer, Rosalba Mansi, Nicolas, Guillaume, Abiraj, Keelara, Fani, Melpomeni, Maria-Luisa Tamma, Renzo Cescato, Maecke, Helmut R., Jean Claude Reubi, Nicolas, Guillaume P.   +22 more
core   +1 more source

Critical role of GRP receptor–expressing neurons in the spinal transmission of imiquimod‐induced psoriatic itch

Neuropsychopharmacology Reports, 2020
Aim Ample evidence indicates that gastrin‐releasing peptide receptor (GRPR)–expressing neurons play a critical role in the transmission of acute itch. However, the pathophysiology of spinal mechanisms underlying intractable itch such as psoriasis remains
Norikazu Kiguchi, Fumihiro Saika, Yohji Fukazawa, Shinsuke Matsuzaki, Shiroh Kishioka   +4 more
doaj   +1 more source

GRPR Drives Metastasis via CRABP2 and FNDC4 Pathways in Lung Adenocarcinoma

Cells
Metastasis is a leading cause of lung adenocarcinoma (LUAD)-related mortality and presents significant challenges for treatment. The gastrin-releasing peptide receptor (GRPR), a member of the G protein-coupled receptor (GPCR) family, has an unclear role ...
Dong-Gun Kim, Eun-Young Choi, Hye-Mi Ahn, Youn-Jae Kim   +3 more
doaj   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review

International Journal of Dermatology, Volume 65, Issue 4, Page 706-723, April 2026.
ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Yagiz Matthew Akiska, Isha Gandhi, Robert Adler, Deena Fayyad, Perya Bhagchandani, Shabnam Afzal, Waleed Adawi, Shivani Patel, Shawn G. Kwatra   +8 more
wiley   +1 more source

Therapeutic advances in pruritus as a model of personalized medicine

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 415-422, March 2026.
Recent advances in itch biology reveal that chronic pruritus arises from distinct neuroimmune pathways driven by cytokines, JAK, BTK and GPCRs. Targeted biologics and small molecule inhibitors such as dupilumab, nemolizumab, remibrutinib and JAK inhibitors precisely modulate these pathways, leading to a new era of personalized therapeutics in pruritus.
Kelsey Auyeung, Ramsey Kubofcik, Brian S. Kim   +2 more
wiley   +1 more source

Photoacoustic signal enhancement in dual-contrast gastrin-releasing peptide receptor-targeted nanobubbles

Frontiers in Bioengineering and Biotechnology, 2023
Translatable imaging agents are a crucial element of successful molecular imaging. Photoacoustic molecular imaging relies on optical absorbing materials to generate a sufficient signal.
Shensheng Zhao, Shensheng Zhao, Leanne Lee, Leanne Lee, Yang Zhao, Yang Zhao, Yang Zhao, Nu-Chu Liang, Yun-Sheng Chen, Yun-Sheng Chen, Yun-Sheng Chen, Yun-Sheng Chen   +11 more
doaj   +1 more source