Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils. [PDF]
Proc Natl Acad Sci U S A, 2012 Neutrophil migration to inflamed sites is crucial for both the initiation of inflammation and resolution of infection, yet these cells are involved in perpetuation of different chronic inflammatory diseases. Gastrin-releasing peptide (GRP) is a neuropeptide that acts through G protein coupled receptors (GPCRs) involved in signal transmission in both ...
Czepielewski RS +8 more
europepmc +7 more sources
Gastrin-releasing peptide receptor (GRPr) promotes EMT, growth, and invasion in canine prostate cancer [PDF]
Prostate, 2016 The gastrin-releasing peptide receptor (GRPr) is upregulated in early and late-stage human prostate cancer (PCa) and other solid tumors of the mammary gland, lung, head and neck, colon, uterus, ovary, and kidney. However, little is known about its role in prostate cancer.
Said M Elshafae +2 more
exaly +5 more sources
GRPR (Gastrin-Releasing Peptide Receptor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014 Bombesin (BB) and gastrin-releasing peptide (GRP) bind with high affinity to the GRP-receptor (GRP-R) which regulates release of gastrointestinal hormones, smooth muscle contraction and proliferation of epithelial as well as cancer cells. The GRP-R is a G-protein coupled receptor (GPCR) which activates phospholipase C signaling pathways.
Moody, TW
openaire +4 more sources
Evaluation of fluorine-labeled gastrin-releasing peptide receptor (GRPR) agonists and antagonists by LC/MS [PDF]
Amino Acids, 2012 An LC/MS method was used to evaluate 2-fluoropropionyl (FP) and 4-fluorobenzoyl (FB) modified bombsin peptides: GRPR agonist [Aca-QWAVGHLM-NH(2)] and antagonist [fQWAVGHL-NHEt], and their hydrophilic linker modified counterparts with the attachment of GGGRDN sequence.
Min Yang +2 more
exaly +5 more sources
Gastrin-Releasing Peptide Receptor Mediates Activation of the Epidermal Growth Factor Receptor in Lung Cancer Cells [PDF]
Neoplasia: An International Journal for Oncology Research, 2005 Gastrin-releasing peptide receptor (GRPR) and the epidermal growth factor receptor (EGFR) are expressed in several cancers including non-small cell lung carcinoma (NSCLC).
Sufi Mary Thomas +5 more
doaj +3 more sources
Frontiers in Molecular Neuroscience, 2023 The prevalence of allergic conjunctivitis in itchy eyes has increased constantly worldwide owing to environmental pollution. Currently, anti-allergic and antihistaminic eye drops are used; however, there are many unknown aspects about the neural circuits
Keiko Takanami +14 more
doaj +2 more sources
Gastrin-Releasing Peptide (GRP) Stimulates Osteoclastogenesis in Periodontitis
Cells, 2020 Periodontitis is a chronic inflammatory disease with alveolar bone resorption and subsequent tooth loss as its ultimate outcomes. Gastrin-releasing peptide (GRP) is a neuropeptide with growth-stimulatory and tumorigenic properties, and neuropeptides have
YunJeong Choi +6 more
doaj +2 more sources
Exploring the theranostic potential of two metabolically stable GRPR-targeting peptides labelled with Ga-68 for PET imaging [PDF]
EJNMMI Radiopharmacy and ChemistryBackground Gastrin-releasing peptide receptor (GRPR) attracts increasing attention as a target for radiotheranostic applications. We previously developed a metabolically stable GRPR-targeting peptide, incorporating α-methyl-L-tryptophan within its ...
Karim Obeid +4 more
doaj +2 more sources
Evolution of the Jawed Vertebrate (Gnathostomata) Stomach Through Gene Repertoire Loss: Findings from Agastric Species [PDF]
Journal of Developmental BiologyThe stomach has been a highly conserved organ throughout vertebrate evolution; however, there are now over 20 lineages composed of monotremes, lungfish and teleost fish displaying a secondary loss of stomach function and morphology.
Jackson Dann, Frank Grützner
doaj +2 more sources
Gastrin-releasing peptide signaling in the nucleus accumbens medial shell regulates neuronal excitability and motivation [PDF]
Nature CommunicationsNeuropeptides are the largest class of neuromodulators. It has been shown that subpopulations of ventral tegmental area (VTA) dopamine neurons express mRNA for the neuropeptide Gastrin-releasing peptide (GRP); however, its functional relevance in ...
Erin E. Aisenberg +5 more
doaj +2 more sources