Results 81 to 90 of about 83,923 (287)

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Soluble Dietary Fiber of Hawthorn Relieves Constipation Induced by Loperamide Hydrochloride by Improving Intestinal Flora and Inflammation, Thereby Regulating the Aquaporin Ion Pathway in Mice

Foods
Dietary fiber can be fermented and utilized by gut microbiota to reshape the gut microbiota, thereby alleviating constipation. This experiment mainly studied the physicochemical functions of hawthorn soluble dietary fiber (HSDF)and its effect and ...
Henghui Zhang, Qixin Zu, Jiancai Zhang, Suwen Liu, Guohua Zhang, Xuedong Chang, Xiaojun Li   +6 more
doaj   +1 more source

Central and peripheral control of food intake

Endocrine Regulations, 2017
The maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive. Th e body weight depends on the balance between the energy intake and energy expenditure. Increased food intake over the energy
Abdalla M. M. I.
doaj   +1 more source

Foods and nutrients modulates the release of gastrointestinal hormones anorexigenic [PDF]

, 2010
FOODS AND NUTRIENTS MODULATES THE RELEASE OF GASTROINTESTINAL HORMONES ANOREXIGENICThe short-term regulation of food intake controls what, how much and when we eat during one day or a single meal.
Zemdegs, Juliane Costa Silva [UNIFESP], Pimentel, Gustavo Duarte [UNIFESP]   +1 more
core  

Artificial Intelligence‐Based Body Composition Analysis Reveals Sex‐Specific Prognostic Markers and Their Clinical Value in Gastric Cancer: A Multicenter Study

Advanced Science, EarlyView.
This study applied AI to quantify multidimensional body composition from CT images in gastric cancer and healthy controls. Distinct sex‐specific patterns and disease‐related alterations were identified and were associated with survival. Higher muscle and fat measures were linked to improved outcomes.
Tianxiang Li, Tingting Liu, Qian Yang, Zhiqing Zhang, Xiaofang Guo, Xiang Wang, Yihan Zhang, Limin Ge, Yu Su, Wenjun Wu, Weihua Guo, Zheng Wang, Lian Yang, Yanfeng Niu   +13 more
wiley   +1 more source

Cellular and subcellular co-storage of gastrointestinal hormones [PDF]

, 2018
© 2018 Dr. Linda Jane FothergillGastrointestinal hormones regulate a diverse range of physiological processes including digestion, metabolism, and food intake, as well as maintaining mucosal integrity and mounting defensive mechanism in response to ...
Fothergill, Linda Jane
core  

Gastrointestinal growth factors and pancreatic islet hormones during postoperative IGF-I supplementation in man

, 2000
Insulin-like growth factor-I (IGF-I) has been demonstrated to exert a nitrogen sparing effect, both experimentally and in patients after abdominal surgery. IGF-I is a major mediator for the anabolic effects of growth hormone (GH).
Larsson, J,, Leinsköld, T, Larsson, J, Adrian, TE, Leinsköld, Ted,, Adrian, TE,, Arnelo, U,, Permert, J,   +7 more
core   +1 more source

Gastrointestinal Hormones, Morphological Characteristics, and Physical Performance in Elite Soccer Players

, 2022
PURPOSE: To determine the relationship between gastrointestinal hormones (leptin, glucagon-like peptide-1), ghrelin, cholecystokinin, peptide YY, morphological characteristics, and physical performances in elite soccer players.METHODS: Q2 Twenty-two ...
Zouhal, Hassane, Ben Aabderrahman, Abderraouf, Clark, Cain C T, Saeidi, Ayoub, Kurtz, Jennifer A., Clark, Cain C. T., Laher, Ismail, Hackney, Anthony C, VanDusseldorp, Trisha A, Triki, Raoua, Hackney, Anthony C., Gaed, Sabri, Salhi, Iyed, Kurtz, Jennifer A   +13 more
core   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source