Results 1 to 10 of about 2,582 (208)

First Evidence of Gastroprotection by Schinus molle: Roles of Nitric Oxide, Prostaglandins, and Sulfhydryls Groups in Its Mechanism of Action

Molecules, 2022
Schinus molle is a plant traditionally used in Mexico to treat gastric disorders. However, no scientific evidence has been reported on its gastroprotective effect. The aim of the current contribution was to conduct a bioassay-guided study on S.
María Elena Sánchez-Mendoza, Yaraset López-Lorenzo, Leticia Cruz-Antonio, Daniel Arrieta-Baez, Miranda Carolina Pérez-González, Jesús Arrieta   +5 more
doaj   +2 more sources

Are the clinical guideline recommendations on gastroprotection being followed? A review in patients taking nonsteroidal anti-inflammatory drugs [PDF]

Revista de Gastroenterología de México (English Edition), 2016
Introduction and aims: The chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) can cause complications in the gastrointestinal tract. The use of proton pump inhibitors (PPIs) is recommended in high-risk patients to prevent them.
J.A. Velasco-Zamora, E. Gómez-Reyes, L. Uscanga   +2 more
doaj   +2 more sources

Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice [PDF]

BMC Musculoskeletal Disorders, 2006
Background Gastrointestinal harm, known to occur with NSAIDs, is thought to be lower with NSAID and gastroprotective agent, and with inhibitors selective to cyclooxygenase-2 (coxibs) at usual plasma concentrations.
Phillips Ceri J, Derry Sheena, Moore R Andrew, McQuay Henry J   +3 more
doaj   +2 more sources

The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms

BMC Complementary and Alternative Medicine, 2017
Background Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to series of adverse effects such as
Ramani Karunakaran, M. Ira Thabrew, G. Mayuri Thammitiyagodage, B. Prasanna Galhena, L.D.A. Menuka Arawwawala   +4 more
doaj   +2 more sources

Gastroprotective effect of hydroalcoholic extract of Ocimum africanum leaves [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2017
Ocimum africanum Lour. (hairy basil, hoary basil or lemon basil) is an aromatic herb in Asian and Thai cuisine that has been used as a carminative, a digestion enhancement and remedy for gastrointestinal disturbance in Thai traditional medicine.
Jaruwat Bunwijit, Bungorn Sripanidkulchai, Wanassanun Pannangrong, Jintana Junlatat, Kittisak Sripanidkulchai   +4 more
doaj   +1 more source

Gastric Ulcer Healing Property of Bryophyllum pinnatum Leaf Extract in Chronic Model In Vivo and Gastroprotective Activity of Its Major Flavonoid

Frontiers in Pharmacology, 2021
Gastric ulcer is a common disease that develops complications such as hemorrhages and perforations when not properly treated. Extended use of drugs in the treatment of this pathology can provoke many adverse effects.
Edilane Rodrigues Dantas De Araújo, Gerlane Coelho Bernardo Guerra, Anderson Wilbur Lopes Andrade, Júlia Morais Fernandes, Valéria Costa Da Silva, Emanuella De Aragão Tavares, Aurigena Antunes De Araújo, Raimundo Fernandes de Araújo Júnior, Raimundo Fernandes de Araújo Júnior, Raimundo Fernandes de Araújo Júnior, Raimundo Fernandes de Araújo Júnior, Silvana Maria Zucolotto, Silvana Maria Zucolotto, Silvana Maria Zucolotto   +13 more
doaj   +1 more source

Gastroprotective Effects of Oral Glycosaminoglycans with Sodium Alginate in an Indomethacin-Induced Gastric Injury Model in Rats

Veterinary Sciences, 2023
The gastrointestinal (GI) mucosal barrier is often exposed to inflammatory and erosive insults, resulting in gastric lesions. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA), chondroitin sulfate (CS), and N-acetylglucosamine (NAG) have shown ...
Sara Traserra, Héctor Cuerda, Adriana Vallejo, Sergi Segarra, Roger Sabata, Marcel Jimenez   +5 more
doaj   +1 more source

Role of Prostaglandins, Nitric oxide, Sulfhydryls and Capsaicin-sensitive Neurons in Gastroprotection of Stigmasterol and β-Sitosterol

Natural Product Communications, 2008
In this investigation the gastroprotective activity of stigmasterol and β-sitosterol was evaluated. Gastric mucosal damage was induced in rats by intragastric ethanol (1 mL/rat).
María Elena Sánchez-Mendoza, Jesús Arrieta, Andrés Navarrete   +2 more
doaj   +1 more source

Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives

Molecules, 2011
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for ...
Guillermo Schmeda-Hirschmann, Daniel Droguett, Paulo González, Francisco Monsalve, Erdem Yesilada, Maria del Mar Afonso, Cristina Theoduloz, Jose Antonio Palenzuela, Mariano Walter Pertino   +8 more
doaj   +1 more source

AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice

Molecules, 2021
Introduction: Adiponectin is a hormone secreted by adipocytes, which exhibits insulin-sensitizing and anti-inflammatory properties and acts through adiponectin receptors: AdipoR1 and AdipoR2.
Hubert Zatorski, Maciej Salaga, Marta Zielińska, Kinga Majchrzak, Agata Binienda, Radzisław Kordek, Ewa Małecka-Panas, Jakub Fichna   +7 more
doaj   +1 more source