Results 21 to 30 of about 2,582 (208)

Bioinspired Quinoline-2 Derivatives Based on the Natural Alkaloid 2-Phenylquinoline from Conchocarpus longifolius (A.St.-Hil.) Kallunki & Pirani: Pharmacological Evaluation of Their Gastroprotective Potential [PDF]

Molecules
The treatment of gastric ulcers based on antisecretory drugs is often associated with side effects and high recurrence rates, reinforcing the need for new therapeutic alternatives.
Sérgio Fallone de Andrade, Eduardo Breviglieri, Ivan Limachi, Luisa Mota da Silva, Thaise Boeing, Lincon Bordignon Somensi, Olov Sterner, Alberto Gimenez, Valdir Cechinel Filho   +8 more
doaj   +2 more sources

Gastroprotection by Nonprostaglandin Substances

, 1989
Cytoprotection is the term originally introduced into gastrointestinal (GI) pa-thophysiology by Robert to describe the unique feature of prostaglandins (PG) to prevent acute necrotic lesions of the GI mucosa at nonantisecretory doses. This phenomenon has been studied extensively, primarily in experimental animals, and two major categories of ...
Jan W. Konturek, Stanislaw J. Konturek
core   +2 more sources

Copper-Derivatives and Gastroprotection

, 1997
The regulation of mucosal microcirculation is involved in maintaining gastric integrity. Limitations to microvascular perfusion, either by direct vasoconstriction or by removal of endogenous vasodilator tone, can lead to the development of mucosal damage, erosion or ulcerations (Whittle, 1981).
L. Franco, G. P. Velo, E. Rizzarelli
core   +2 more sources

Vonoprazan vs Proton Pump Inhibitors for Gastroprotection in Anticoagulated Patients: A Real-World Cohort Study. [PDF]

Cureus
Introduction Oral anticoagulation is associated with an increased risk of GI bleeding. Proton pump inhibitors (PPIs) are commonly used for gastroprotection but have pharmacologic limitations.
Ahmed H, Alabdul Razzak I, Abdulrazzak E, Gomaa S, Abdelrazeq K, Korimilli A, Khetarpal R, Almahmood M, Shahzad A, Elsokary K.   +9 more
europepmc   +3 more sources

Freshwater Clam Extract Attenuates Indomethacin-Induced Gastric Damage In Vitro and In Vivo

Foods, 2022
Contemporary pharmacological studies have reported that freshwater clam (Corbicula fluminea) can provide a broad spectrum of bioactivities, including antioxidant, anticancer, antihypertensive, hepatoprotective, and hypocholesterolemic effects. The aim of
Fuad Sauqi Isnain, Nai-Chen Liao, Hui-Yun Tsai, Yu-Jie Zhao, Chien-Hua Huang, Jue-Liang Hsu, Agustin Krisna Wardani, Yu-Kuo Chen   +7 more
doaj   +1 more source

Flavonoids with Gastroprotective Activity [PDF]

Molecules, 2009
Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs.
de Lira Mota, Kelly Samara, Nunes Dias, Guilherme Eduardo, Ferreira Pinto, Meri Emili, Luiz-Ferreira, Anderson, Monteiro Souza-Brito, Alba Regina, Hiruma-Lima, Clelia Akiko, Barbosa-Filho, Jose Maria, Batista, Leonia Maria   +7 more
openaire   +7 more sources

Amtolmetin: A Reappraisal of NSAID with Gastroprotection [PDF]

Arthritis, 2016
Aim. To assess the gastrosparing effect of amtolmetin guacyl (AMG) against other nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteo-/rheumatoid arthritis. Methods. A literature search was done in the electronic databases (PubMed, Google Scholar, Embase, and Scopus) with key words “amtolmetin guacyl”, “amtolmetin”, and “arthritis ...
Garg, Amit, Shoeb, Ahsan, Moodahadu, Latha Subramanya, Sharma, Akhilesh, Gandhi, Arul, Akku, Shyam   +5 more
openaire   +2 more sources

Gastroprotective Activity of Epitaondiol and Sargaol [PDF]

Natural Product Communications, 2011
The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying ...
Areche, Carlos, San Martín Barrientos, Aurelio, Rovirosa, Juana, Sepúlveda, Beatriz   +3 more
openaire   +2 more sources

Gastroprotective Mechanisms

, 2022
Gastric ulcer (GU), a common type of peptic ulcer, results from an imbalance in the action of protective and aggressive agents. Gastroprotective mechanisms are mucus layer, gastric epithelium, gastric blood flow, gastric neurons, mucosal repair capacity, and immune system.
Cirlane Alves Araujo de Lima, Robson Silva de Lima, Jesica Batista de Souza, Ariel de Souza Graça, Sara Maria Thomazzi, Josemar Sena Batista, Charles dos Santos Estevam   +6 more
openaire   +2 more sources

Bombesin-Induced Gastroprotection

Annals of Surgery, 2005
Bombesin is an endogenous gut peptide that is prominent in the stomach. In addition to its effects on modulating acid and gut peptide secretion, recent evidence indicates that bombesin is a potent gastroprotective agent. This review article examines the ability of bombesin to prevent gastric injury.
Sonlee D, West, David W, Mercer
openaire   +3 more sources