Results 21 to 30 of about 2,310 (209)

Gastroprotective Activity of Epitaondiol and Sargaol [PDF]

Natural Product Communications, 2011
The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying ...
Areche, Carlos, San Martín Barrientos, Aurelio, Rovirosa, Juana, Sepúlveda, Beatriz   +3 more
openaire   +2 more sources

Role of Prostaglandins, Nitric oxide, Sulfhydryls and Capsaicin-sensitive Neurons in Gastroprotection of Stigmasterol and β-Sitosterol

Natural Product Communications, 2008
In this investigation the gastroprotective activity of stigmasterol and β-sitosterol was evaluated. Gastric mucosal damage was induced in rats by intragastric ethanol (1 mL/rat).
María Elena Sánchez-Mendoza, Jesús Arrieta, Andrés Navarrete   +2 more
doaj   +1 more source

Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives

Molecules, 2011
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for ...
Guillermo Schmeda-Hirschmann, Daniel Droguett, Paulo González, Francisco Monsalve, Erdem Yesilada, Maria del Mar Afonso, Cristina Theoduloz, Jose Antonio Palenzuela, Mariano Walter Pertino   +8 more
doaj   +1 more source

AdipoRon, an Orally Active, Synthetic Agonist of AdipoR1 and AdipoR2 Receptors Has Gastroprotective Effect in Experimentally Induced Gastric Ulcers in Mice

Molecules, 2021
Introduction: Adiponectin is a hormone secreted by adipocytes, which exhibits insulin-sensitizing and anti-inflammatory properties and acts through adiponectin receptors: AdipoR1 and AdipoR2.
Hubert Zatorski, Maciej Salaga, Marta Zielińska, Kinga Majchrzak, Agata Binienda, Radzisław Kordek, Ewa Małecka-Panas, Jakub Fichna   +7 more
doaj   +1 more source

GASTROPROTECTIVE NSAIDs

Journal of Drug Delivery and Therapeutics, 2018
NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-Origin, conjugates of NSAIDs (especially the carboxylic
DN Prasad, Parminder Kaur, Mohammad Shahnaz   +2 more
openaire   +2 more sources

Addendum: Lallana, M.J. et al. Use of Non-Steroidal Anti-Inflammatory Drugs and Associated Gastroprotection in a Cohort of Workers. 2018, 15, 1836 [PDF]

, 2020
The authors wish to make the following correction to this paper [1]: Change in Funding In the original version of our article (Lallana, M.J. et al. Use of Non-Steroidal Anti-Inflammatory Drugs and Associated Gastroprotection in a Cohort of Workers. 2018,
Feja, C., Malo, S., Aguilar-Palacio, I., Rabanaque, M.J., Lallana, M.J.   +4 more
core   +1 more source

Non-Invasive Remote Ischemic Preconditioning May Protect the Gastric Mucosa Against Ischemia-Reperfusion-Induced Injury Through Involvement of Glucocorticoids

Frontiers in Pharmacology, 2021
Remote ischemic preconditioning (RIPC) is one of the most effective approaches to attenuate tissue injury caused by severe ischemia-reperfusion (I/R). Experimental studies have demonstrated that RIPC is capable of producing a protective effect not only ...
Ludmila Filaretova, Olga Komkova, Maria Sudalina, Natalia Yarushkina   +3 more
doaj   +1 more source

A Case of Refractory Peptic Ulcer with Choledochoduodenal Fistula Successfully Treated by Biliary Stent Placement Using an Ultrathin Endoscopic Rendezvous Technique: A Case Report. [PDF]

DEN Open
ABSTRACT Choledochoduodenal fistula (CDF) is an abnormal communication between the common bile duct and the duodenum. While gallstones are the primary cause, peptic ulcer‐related CDF has become rare due to the widespread antiulcer therapy. Nevertheless, CDF remains clinically relevant as symptoms are often vague and diagnosis is frequently incidental ...
Miyashita Y, Koiwai A, Urita E, Takemoto M, Itoh T, Inomata N, Hirota M, Satoh K.   +7 more
europepmc   +2 more sources

Current Trends in NSAID Prescribing for Osteoarthritis and Axial Spondyloarthritis: Insights From Moroccan Rheumatologists Practices. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Nonsteroidal anti‐inflammatory drugs (NSAIDs) remain the cornerstone of symptomatic management in osteoarthritis (OA) and axial spondyloarthritis (axial SpA), but safety concerns have reshaped prescribing behaviors. This study aimed to describe current NSAID prescribing practices among Moroccan rheumatologists for both ...
El Binoune I, Zineb B, Rostom S, Amine B, Bahiri R.   +4 more
europepmc   +2 more sources

Gastroprotective effects of oral nucleotide administration [PDF]

Gut, 2005
Background and aims: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health. However, there has been only limited scientific study regarding the true biological activity of orally administered nucleotides. We therefore tested their
Belo, A, Marchbank, T, Fitzgerald, A, Ghosh, S, Playford, RJ   +4 more
openaire   +3 more sources