NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-Origin, conjugates of NSAIDs (especially the carboxylic
DN Prasad +2 more
openaire +2 more sources
Remote ischemic preconditioning (RIPC) is one of the most effective approaches to attenuate tissue injury caused by severe ischemia-reperfusion (I/R). Experimental studies have demonstrated that RIPC is capable of producing a protective effect not only ...
Ludmila Filaretova +3 more
doaj +1 more source
Non-steroidal anti-inflammatory drugs and gastroprotection gap among Family Physicians: Results from a survey [PDF]
IntroductionUse of non-steroidal anti-inflammatory drugs (NSAIDs) has increased over the last few years and identification of gastrointestinal risk factors is a key factor for prevention of its complications.
Graça Coutinho +7 more
core +1 more source
Addendum: Lallana, M.J. et al. Use of Non-Steroidal Anti-Inflammatory Drugs and Associated Gastroprotection in a Cohort of Workers. 2018, 15, 1836 [PDF]
The authors wish to make the following correction to this paper [1]: Change in Funding In the original version of our article (Lallana, M.J. et al. Use of Non-Steroidal Anti-Inflammatory Drugs and Associated Gastroprotection in a Cohort of Workers. 2018,
Feja, C. +4 more
core +1 more source
Use of non-steroidal anti-inflammatory drugs and associated gastroprotection in a cohort of workers [PDF]
Background: This study describes the prevalence of non-steroidal anti-inflammatory drug (NSAID) use, and analyses prescribing patterns of NSAIDs and associated gastroprotection.
Feja, C. +9 more
core +1 more source
Carbon Monoxide (CO) Released from Tricarbonyldichlororuthenium (II) Dimer (CORM-2) in Gastroprotection against Experimental Ethanol-Induced Gastric Damage. [PDF]
The physiological gaseous molecule, carbon monoxide (CO) becomes a subject of extensive investigation due to its vasoactive activity throughout the body but its role in gastroprotection has been little investigated.
Juliusz Adamski +15 more
core +1 more source
Protective Effects of Chitosan-Bilirubin Nanoparticles Against Ethanol-Induced Gastric Ulcers
Zhiwei Huang,1– 3,* Yannan Shi,2,* Hengcai Wang,2,* Changju Chun,3 Longwang Chen,1,4 Kang Wang,1,4 Zhongqiu Lu,1,4 Yingzheng Zhao,2 Xinze Li1,4 1Department of Emergency, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou ...
Huang Z +8 more
doaj
Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves [PDF]
Background: Melastoma malabathricum L. (Melastomaceae) is a small shrub with various medicinal uses. The present study was carried out to determine the gastroprotective mechanisms of methanol extract of M. malabathricum leaves (MEMM) in rats.
Teh, Lay Kek +11 more
core +2 more sources
Gastroprotective Role of Glucocorticoid Hormones
Gastric ulcer disease remains widespread; a stressful lifestyle and nonsteroidal antiinflammatory drugs (NSAIDs) make significant contributions to this pathological situation. The findings overviewed here support the idea that glucocorticoid hormones released in response to acute stress or NSAIDs act as gastroprotective substances and exert many of the
Filaretova, Ludmila +4 more
openaire +4 more sources
Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk
BACKGROUND AND PURPOSE: Ghrelin, a gut-brain peptide, is considered a gastroprotective factor in gastric mucosa. We investigated the role of prostaglandins (PG) and the possible interplay between PGs and nitric oxide (NO) in ghrelin gastroprotection ...
F. Pagani +10 more
core +1 more source

