Results 41 to 50 of about 2,582 (208)

Gastroprotective effects of Zingiber officinale in rodent models of peptic ulcers: A systematic review and meta-analysis [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Peptic ulcer remains a significant global health concern, particularly in low-resource settings. Conventional treatments are often associated with side effects and recurrence, prompting interest in herbal therapies such as Zingiber officinale ...
Coana Sukmagautama, Reviono, Wachid Putranto, Eti P. Pamungkasari, Hartono, Risya Cilmiaty, Paramasari Dirgahayu   +6 more
doaj   +1 more source

Nonsteroidal anti-inflammatory drugs, gastroprotection, and benefit-risk.

, 2014
BACKGROUND: Gastroprotective agents (GPA) substantially reduce morbidity and mortality with long-term nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin.
Moore, RA, Emery, P, Derry, Sheena, Derry, S, Simon, LS   +4 more
core   +1 more source

Mechanisms of gastroprotection by transdermal nitroglycerin in the rat [PDF]

British Journal of Pharmacology, 1999
Nitric oxide (NO) donors prevent experimentally‐induced gastric mucosal damage, but their clinical utility is limited by short duration of action or unsuitability of the pharmaceutical form employed. This study analyses the gastroprotection elicited by a clinically used mode of continuous administration of an NO donor, namely the nitroglycerin patch.
Calatayud S, Sanz M, Canet A, Bello R, de Rojas F, Esplugues J   +5 more
openaire   +3 more sources

Pentagastrin gastroprotection against acid is related to H₂ receptor activation but not acid secretion

, 1998
Background—Pentagastrin enhances gastric mucosal defence mechanisms against acid and protects the gastric mucosa from experimental injury.Aims—To investigate whether this gastroprotection is mediated by histamine receptors or occurs as a secondary effect
J D Kaunitz, S Tanaka, Y Akiba
core   +1 more source

Sonchus oleraceus L. Promotes Gastroprotection in Rodents via Antioxidant, Anti-Inflammatory, and Antisecretory Activities

, 2022
Sonchus oleraceus L. is an edible and medicinal plant used to treat stomachache and gastric ailments around the world. Thus, this study aimed to determine the gastroprotective mode of action of hydroalcoholic extract of S. oleraceus (HES).
Kaio Silva Nunes, Ruan, Gutiérrez, Max V., Serpa, Patricia Z., Zanatta, Maria Eduarda D. C., Miorando, Daniela, Vilegas, Wagner, Ernetti, Jackeline, Gutiérrez, Max V. [UNESP], Somensi, Lincon B., Bianchin Gomes, Denise, Vecchia, Cristian A. D., Silva, Luisa M., Roman, Walter A., Wildner, Silvana M., Roman Junior, Walter A., Locateli, Gelvani, Vilegas, Wagner [UNESP]   +16 more
core   +1 more source

Gasztroenterológiai-kardiológiai multidiszciplináris konszenzus a hatékony gasztroprotekció szükségességéről antitrombotikus kezelés alkalmazásakor : A Magyar Gasztroenterológiai Társaság és a Magyar Kardiológusok Társaságának közös állásfoglalása

, 2023
Az antitrombotikus (thrombocytaaggregáció-gátló – TAG és antikoaguláns) szerek alkalmazása nélkülözhetetlen a szív- és érrendszeri (kardiovaszkuláris – CV) betegségek kezelésében.
Márk Juhász, Vincze, Áron, Simonyi, Gábor, Endre Kolossváry, Zoltán Járai, Szabolcs Békássy, Róbert Gábor Kiss, Aradi, Dániel, Péter Torzsa, Torzsa, Péter, Szőnyi, Mihály, Gábor Simonyi, Herszényi, László, Juhász, Márk, Sándor Nárdai, Békássy, Szabolcs, László Herszényi, Nardai, Sándor, Áron Vincze, Zsolt Tulassay, Mihály Szőnyi, Kolossváry, Endre, Becker, Dávid, Dávid becker, Dániel Aradi, János Tomcsányi, Tomcsányi, János, Járai, Zoltán, Tulassay, Zsolt, Kiss, Róbert Gábor   +29 more
core   +1 more source

Mechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Rats

Molecules, 2010
Leaves and bark infusions Anacardium humile St. Hil. (Anacardiaceae), known as in Brazil as “cajuzinho do cerrado”, have been used in folk medicine as an alternative treatment for ulcers and gastritis.
Alba Regina Monteiro Souza Brito, Wagner Vilegas, Lourdes Campaner Santos, Clélia Akiko Hiruma-Lima, Cláudia Helena Pellizzon, Elisângela Farias-Silva, Ana Beatriz Albino de Almeida, Leônia Maria Batista, Anderson Luiz-Ferreira, Ana Cristina Alves de Almeida, Victor Barbastefano, Maíra Cola   +11 more
doaj   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Exposure to CYP2C19‐metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire, Andrew T. Lambarth, Ayesha Saleem, Daniel R. Burrage   +3 more
wiley   +1 more source

Gastroprotection among new chronic users of non-steroidal anti-inflammatory drugs: a study of utilization and adherence in the Netherlands

, 2009
Objective: To describe the use of gastroprotection (GP) among new chronic users of NSAIDs in the Netherlands by gastrointestinal (GI) risk factor (RF) score. Methods: Data for this retrospective follow-up study were extracted from the PHARMO database. We
Gaugris, S, Herings, RMC (Ron), van den Bemt, B.J.F. (Bart), Kuipers, Ernst, van der Linden, MW (Marleen), van Herk-Sukel, MPP   +5 more
core   +1 more source