Results 51 to 60 of about 2,310 (209)

Gastroprotection among new chronic users of non-steroidal anti-inflammatory drugs: a study of utilization and adherence in the Netherlands

, 2009
Objective: To describe the use of gastroprotection (GP) among new chronic users of NSAIDs in the Netherlands by gastrointestinal (GI) risk factor (RF) score. Methods: Data for this retrospective follow-up study were extracted from the PHARMO database. We
Gaugris, S, Herings, RMC (Ron), van den Bemt, B.J.F. (Bart), Kuipers, Ernst, van der Linden, MW (Marleen), van Herk-Sukel, MPP   +5 more
core   +1 more source

Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage

Pharmaceuticals, 2018
The development of the gastric lesion is complex and the result of the imbalance between aggressive and protective factors, involving the generation of free radicals and disturbance in nitric oxide (NO) production.
José Gerardo Carneiro, Ticiana de Brito Lima Holanda, Ana Luíza Gomes Quinderé, Annyta Fernandes Frota, Vitória Virgínia Magalhães Soares, Rayane Siqueira de Sousa, Manuela Araújo Carneiro, Dainesy Santos Martins, Antoniella Souza Gomes Duarte, Norma Maria Barros Benevides   +9 more
doaj   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Gasztroenterológiai-reumatológiai konszenzus a hatékony gasztroprotekció szükségességéről nemszteroid gyulladáscsökkentők alkalmazásakor = Gastroenterologist-Rheumatologist Expert Consensus Addressing the Need of Effective Gastroprotection During Therapy with Non-Steroidal Anti-Inflammatory Drugs [PDF]

, 2020
Non-steroidal anti-inflammatory drugs (NSAIDs) are essential agents in the treatment of musculoskeletal disorders. However, their use is associated with mucosal injury of gastrointestinal tract, including the development of peptic ulcer disease and its ...
Kovács, László, Szekanecz, Zoltán, Vincze, Áron, Herszényi, László, Altorjay, István, Tamaskó, Mónika, Tulassay, Zsolt   +6 more
core   +1 more source

From Selye’s and Szabo’s Cysteamine-Duodenal Ulcer in Rats to Dopamine in the Stomach: Therapy Significance and Possibilities

Pharmaceuticals, 2023
We reviewed gastric ulcer healing by dopamine considering several distinctive duodenal key points. Selye and Szabo describe the cysteamine-induced duodenal ulcer in rats as a duodenal stress ulcer in patients.
Predrag Sikiric, Alenka Boban Blagaic, Ivan Krezic, Helena Zizek, Luka Kalogjera, Ivan Maria Smoday, Vlasta Vukovic, Katarina Oroz, Helen Marie Chiddenton, Sara Buric, Marko Antunovic, Slaven Gojkovic, Sanja Strbe, Milena Skocic, Suncana Sikiric, Marija Milavic, Lidija Beketic Oreskovic, Antonio Kokot, Antun Koprivanac, Ivan Dobric, Marko Sever, Mario Staresinic, Lovorka Batelja Vuletic, Anita Skrtic, Sven Seiwerth   +24 more
doaj   +1 more source

Non-steroidal anti-inflammatory drugs and gastroprotection gap among Family Physicians: Results from a survey

, 2013
IntroductionUse of non-steroidal anti-inflammatory drugs (NSAIDs) has increased over the last few years and identification of gastrointestinal risk factors is a key factor for prevention of its complications.
Graça Coutinho, Areia, Miguel, Pereira, António Dias, Banhudo, António, Miguel Areia, António Banhudo, Coutinho, Graça, António Dias Pereira   +7 more
core   +1 more source

Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity

International Journal of Nanomedicine, 2020
Mohammed M Mehanna,1,2 Amina Tarek Mneimneh,2 Souraya Domiati,3 Ahmed N Allam4 1Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab ...
Mehanna MM, Mneimneh AT, Domiati S, Allam AN   +3 more
doaj  

Possibilities of gastroprotective therapy in NSA1Dinduced gastropathies with De-Nol

Научно-практическая ревматология, 2004
Objective. To assess efficacy of De-Nol in NSAID-induced gastropathies. Material and Methods. 45 pts with rheumatic diseases taking NSAID with gastric and/or duodenal ulcer up to 1 cm of size or multiple (>10) gastric erosions (MGE) confirmed with ...
A. E. Karateev, E L Nassonov, S G Radenska-Lopovok   +2 more
doaj   +1 more source

Gastroprotective Effects of Hexanic Extract of the Leaves of Spondias purpurea and Its Underlying Mechanism of Action

Journal of Food Process Engineering, Volume 49, Issue 6, June 2026.
Histopathological analysis of gastric mucosa stained with HE and PAS of rats submitted to induction of ulcers with acetic acid. The animals were treated orally with vehicle (injured control), ranitidine, and SpHE (25 mg/kg) for 14 days. In A and B, observe preserved mucosa and submucosal layers (black asterisk) and presence of the barrier protection of
Cynthia Layse Ferreira de Almeida, Samara Alves Brito, Temístocles Italo de Santana, Henrique Alves Bandeira Alves Costa, Caroline Leal Rodrigues Soares, Natalie Emanuelle Ribeiro Rodrigues, Vanda Lucia dos Santos, Almir Gonçalves Wanderley, Henrique D. M. Coutinho, Teresinha Gonçalves da Silva   +9 more
wiley   +1 more source

Traditional medicine and gastroprotective crude drugs

Journal of Ethnopharmacology, 2005
A frequent question when dealing with the search for gastroprotective compounds from natural sources is how far or close are both the plant preparations and extract amounts from the doses recommended in traditional medicine and what should be considered realistic levels for experimental studies. The administration way is oral and therefore extracts and
Schmeda-Hirschmann, G., Yesilada, E.
openaire   +6 more sources