Results 11 to 20 of about 285 (135)
Flavonoids with Gastroprotective Activity [PDF]
Molecules, 2009 Peptic ulcers are a common disorder of the entire gastrointestinal tract that occurs mainly in the stomach and the proximal duodenum. This disease is multifactorial and its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs.
de Lira Mota, Kelly Samara +7 more
openaire +7 more sources
, 2022 Gastric ulcer (GU), a common type of peptic ulcer, results from an imbalance in the action of protective and aggressive agents. Gastroprotective mechanisms are mucus layer, gastric epithelium, gastric blood flow, gastric neurons, mucosal repair capacity, and immune system.
Cirlane Alves Araujo de Lima +6 more
openaire +2 more sources
Bombesin-Induced Gastroprotection
Annals of Surgery, 2005 Bombesin is an endogenous gut peptide that is prominent in the stomach. In addition to its effects on modulating acid and gut peptide secretion, recent evidence indicates that bombesin is a potent gastroprotective agent. This review article examines the ability of bombesin to prevent gastric injury.
Sonlee D, West, David W, Mercer
openaire +3 more sources
Natural Product Communications, 2008 In this investigation the gastroprotective activity of stigmasterol and β-sitosterol was evaluated. Gastric mucosal damage was induced in rats by intragastric ethanol (1 mL/rat).
María Elena Sánchez-Mendoza +2 more
doaj +1 more source
Synthesis and Pharmacological Activity of Diterpenylnaphthoquinone Derivatives
Molecules, 2011 New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for ...
Guillermo Schmeda-Hirschmann +8 more
doaj +1 more source
Amtolmetin: A Reappraisal of NSAID with Gastroprotection [PDF]
Arthritis, 2016 Aim. To assess the gastrosparing effect of amtolmetin guacyl (AMG) against other nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteo-/rheumatoid arthritis. Methods. A literature search was done in the electronic databases (PubMed, Google Scholar, Embase, and Scopus) with key words “amtolmetin guacyl”, “amtolmetin”, and “arthritis ...
Garg, Amit +5 more
openaire +2 more sources
Molecules, 2021 Introduction: Adiponectin is a hormone secreted by adipocytes, which exhibits insulin-sensitizing and anti-inflammatory properties and acts through adiponectin receptors: AdipoR1 and AdipoR2.
Hubert Zatorski +7 more
doaj +1 more source
Journal of Drug Delivery and Therapeutics, 2018 NSAIDs suffer from a serious drawback of GI-SEs caused particularly after chronic use. There is evidence concerning the participation of ROS in the etiology & pathophysiology of digestive system disorders like GI-inflammation & gastro ulcer. With the aim to retard the adverse effects of GI-Origin, conjugates of NSAIDs (especially the carboxylic
DN Prasad +2 more
openaire +2 more sources
Gastroprotective Activity of Epitaondiol and Sargaol [PDF]
Natural Product Communications, 2011 The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25- 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying ...
Areche, Carlos +3 more
openaire +2 more sources
Frontiers in Pharmacology, 2021 Remote ischemic preconditioning (RIPC) is one of the most effective approaches to attenuate tissue injury caused by severe ischemia-reperfusion (I/R). Experimental studies have demonstrated that RIPC is capable of producing a protective effect not only ...
Ludmila Filaretova +3 more
doaj +1 more source