Results 11 to 20 of about 2,310 (209)

First Evidence of Gastroprotection by Schinus molle: Roles of Nitric Oxide, Prostaglandins, and Sulfhydryls Groups in Its Mechanism of Action

Molecules, 2022
Schinus molle is a plant traditionally used in Mexico to treat gastric disorders. However, no scientific evidence has been reported on its gastroprotective effect. The aim of the current contribution was to conduct a bioassay-guided study on S.
María Elena Sánchez-Mendoza, Yaraset López-Lorenzo, Leticia Cruz-Antonio, Daniel Arrieta-Baez, Miranda Carolina Pérez-González, Jesús Arrieta   +5 more
doaj   +2 more sources

Are the clinical guideline recommendations on gastroprotection being followed? A review in patients taking nonsteroidal anti-inflammatory drugs

Revista de Gastroenterología de México (English Edition), 2016
Introduction and aims: The chronic use of nonsteroidal anti-inflammatory drugs (NSAIDs) can cause complications in the gastrointestinal tract. The use of proton pump inhibitors (PPIs) is recommended in high-risk patients to prevent them.
J.A. Velasco-Zamora, E. Gómez-Reyes, L. Uscanga   +2 more
doaj   +2 more sources

Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice

BMC Musculoskeletal Disorders, 2006
Background Gastrointestinal harm, known to occur with NSAIDs, is thought to be lower with NSAID and gastroprotective agent, and with inhibitors selective to cyclooxygenase-2 (coxibs) at usual plasma concentrations.
Phillips Ceri J, Derry Sheena, Moore R Andrew, McQuay Henry J   +3 more
doaj   +3 more sources

The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms

BMC Complementary and Alternative Medicine, 2017
Background Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to series of adverse effects such as
Ramani Karunakaran, M. Ira Thabrew, G. Mayuri Thammitiyagodage, B. Prasanna Galhena, L.D.A. Menuka Arawwawala   +4 more
doaj   +2 more sources

Calcitonin Gene-Related Peptide Signalling in Alcohol Use Disorders: A Scoping Review. [PDF]

Drug Alcohol Rev
ABSTRACT Issue Alcohol use disorders (AUD) represent a major global health burden, and currently available pharmacological treatments show limited and heterogeneous efficacy. Calcitonin gene‐related peptide (CGRP) is a pleiotropic neuropeptide involved in stress regulation and neuroimmune signalling, and is an established therapeutic target in migraine.
Pellesi L, Ahmad TA, Guerzoni S.
europepmc   +2 more sources

Proton Pump Inhibitors Prescribing Behaviors and Rationalization Strategies Among Healthcare Providers in Southeast Asia. [PDF]

Pharmacol Res Perspect
Long‐term proton pump inhibitor (PPI) therapy raises significant concerns regarding cost‐effectiveness and adverse effects, necessitating effective deprescribing strategies. An evaluation of 763 Southeast Asian healthcare providers revealed two distinct prescriber phenotypes, where a proactive cluster utilized diverse, guideline‐based rationalization ...
Quach DT, Huynh TM, Galang AJG, Dao HV, Chirapongsathorn S, Kijdamrongthum P, Khan RA, Ong AM, Cheah WK, Khaira KS, Tan SF, Sollano J, Syam AF, Chua TS, Leelakusolvong S, Lee YY.   +15 more
europepmc   +2 more sources

Gastroprotective Effects of Oral Glycosaminoglycans with Sodium Alginate in an Indomethacin-Induced Gastric Injury Model in Rats

Veterinary Sciences, 2023
The gastrointestinal (GI) mucosal barrier is often exposed to inflammatory and erosive insults, resulting in gastric lesions. Glycosaminoglycans (GAGs), such as hyaluronic acid (HA), chondroitin sulfate (CS), and N-acetylglucosamine (NAG) have shown ...
Sara Traserra, Héctor Cuerda, Adriana Vallejo, Sergi Segarra, Roger Sabata, Marcel Jimenez   +5 more
doaj   +1 more source

Bombesin-Induced Gastroprotection

Annals of Surgery, 2005
Bombesin is an endogenous gut peptide that is prominent in the stomach. In addition to its effects on modulating acid and gut peptide secretion, recent evidence indicates that bombesin is a potent gastroprotective agent. This review article examines the ability of bombesin to prevent gastric injury.
Sonlee D, West, David W, Mercer
openaire   +3 more sources

Amtolmetin: A Reappraisal of NSAID with Gastroprotection [PDF]

Arthritis, 2016
Aim. To assess the gastrosparing effect of amtolmetin guacyl (AMG) against other nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteo-/rheumatoid arthritis. Methods. A literature search was done in the electronic databases (PubMed, Google Scholar, Embase, and Scopus) with key words “amtolmetin guacyl”, “amtolmetin”, and “arthritis ...
Garg, Amit, Shoeb, Ahsan, Moodahadu, Latha Subramanya, Sharma, Akhilesh, Gandhi, Arul, Akku, Shyam   +5 more
openaire   +2 more sources

Gastroprotective Mechanisms

, 2022
Gastric ulcer (GU), a common type of peptic ulcer, results from an imbalance in the action of protective and aggressive agents. Gastroprotective mechanisms are mucus layer, gastric epithelium, gastric blood flow, gastric neurons, mucosal repair capacity, and immune system.
Cirlane Alves Araujo de Lima, Robson Silva de Lima, Jesica Batista de Souza, Ariel de Souza Graça, Sara Maria Thomazzi, Josemar Sena Batista, Charles dos Santos Estevam   +6 more
openaire   +2 more sources