Results 1 to 10 of about 50,858 (171)

A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation in Xenopus [PDF]

Cell Reports, 2012
Discovering how histone variants that mark distinct chromatin regions affect a developmental program is a major challenge in the epigenetics field. To assess the importance of the H3.3 histone variant and its dedicated histone chaperone HIRA, we used an ...
Emmanuelle Szenker‐Ravi, Nicolas Lacoste, Geneviève Almouzni   +2 more
openalex   +3 more sources

Alternative splicing dynamics during gastrulation in mouse embryo. [PDF]

Sci Rep
Alternative splicing (AS) plays an essential role in development, differentiation and carcinogenesis. However, the mechanisms underlying splicing regulation during mouse embryo gastrulation remain unclear.
Wang W, Zhang Y, Zhai Y, Yang W, Xing Y.
europepmc   +2 more sources

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation

Biology Open, 2022
Formation of a properly sized and patterned embryo during gastrulation requires a well-coordinated interplay between cell proliferation, lineage specification and tissue morphogenesis.
Tingxu Chen, Heather Alcorn, Sujan Devbhandari, Dirk Remus, Elizabeth Lacy, Danwei Huangfu, Kathryn V. Anderson   +6 more
doaj   +1 more source

Fishing for drugs

eLife, 2022
Screening for drugs that disrupt embryonic development in zebrafish can help identify treatments that suppress metastasis.
Chinyere Kemet, Emily Hill, Hui Feng
doaj   +1 more source

Genetically programmed retinoic acid deficiency during gastrulation phenocopies most known developmental defects due to acute prenatal alcohol exposure in FASD

Frontiers in Cell and Developmental Biology, 2023
Fetal Alcohol Spectrum Disorder (FASD) arises from maternal consumption of alcohol during pregnancy affecting 2%–5% of the Western population. In Xenopus laevis studies, we showed that alcohol exposure during early gastrulation reduces retinoic acid (RA)
B. Petrelli, A. Oztürk, M. Pind, H. Ayele, A. Fainsod, G. G. Hicks   +5 more
doaj   +1 more source

Virtual cells in a virtual microenvironment recapitulate early development-like patterns in human pluripotent stem cell colonies

Stem Cell Reports, 2023
Summary: The mechanism by which morphogenetic signals engage the regulatory networks responsible for early embryonic tissue patterning is incompletely understood.
Himanshu Kaul, Nicolas Werschler, Ross D. Jones, M. Mona Siu, Mukul Tewary, Andrew Hagner, Joel Ostblom, Daniel Aguilar-Hidalgo, Peter W. Zandstra   +8 more
doaj   +1 more source

Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos

eLife, 2020
Ventral furrow formation, the first step in Drosophila gastrulation, is a well-studied example of tissue morphogenesis. Rho1 is highly active in a subset of ventral cells and is required for this morphogenetic event.
Ashley Rich, Richard G Fehon, Michael Glotzer   +2 more
doaj   +1 more source

Notch-dependent and -independent transcription are modulated by tissue movements at gastrulation

eLife, 2022
Cells sense and integrate external information from diverse sources that include mechanical cues. Shaping of tissues during development may thus require coordination between mechanical forces from morphogenesis and cell-cell signalling to confer ...
Julia Falo-Sanjuan, Sarah Bray
doaj   +1 more source

Random migration of induced pluripotent stem cell-derived human gastrulation-stage mesendoderm. [PDF]

PLoS ONE, 2018
Gastrulation is the initial systematic deformation of the embryo to form germ layers, which is characterized by the placement of appropriate cells in their destined locations.
Yuta Yamamoto, Shota Miyazaki, Kenshiro Maruyama, Ryo Kobayashi, Minh Nguyen Tuyet Le, Ayumu Kano, Akiko Kondow, Shuji Fujii, Kiyoshi Ohnuma   +8 more
doaj   +1 more source

The Adaptor Protein Lurap1 Is Required for Cell Cohesion during Epiboly Movement in Zebrafish

Biology, 2021
Cell adhesion and polarized cellular behaviors play critical roles in a wide variety of morphogenetic events. In the zebrafish embryo, epiboly represents an important process of epithelial morphogenesis that involves differential cell adhesion and ...
Ji-Tong Li, Xiao-Ning Cheng, Chong Zhang, De-Li Shi, Ming Shao   +4 more
doaj   +1 more source