Results 91 to 100 of about 10,115 (192)

The TissueTractor: A Device for Applying Large Strains to Tissues and Cells for Simultaneous High‐Resolution Live Cell Microscopy

Small Methods, EarlyView.
Mechanical strain influences tissue development, homeostasis, and disease. The TissueTractor, a high‐strain stretcher system, enables high‐resolution imaging of live tissues and cells under strain, revealing cellular strain heterogeneity, cytoskeletal remodeling, and morphological adaptations in various model systems.
Jing Yang, Emily Hearty, Yingli Wang, Deepthi S. Vijayraghavan, Timothy Walter, Sommer Anjum, Carsten Stuckenholz, Ya‐Wen Cheng, Sahana Balasubramanian, Yicheng Dong, Adam V. Kwiatkowski, Lance A. Davidson   +11 more
wiley   +1 more source

The gastrulation of the partial embryos of Sphaerechinus [PDF]

Archiv für Entwickelungsmechanik der Organismen, 1903
1) The 1/2 and 1/4 larvae of Sphaerechinus contain only a half and a fourth respectively of the total number of cells in the whole larva. These cells are, therefore, proportionately twice and four times too large. There is no regulation in cell-size.
openaire   +2 more sources

Ethanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects

Biology Open, 2013
Summary Fetal alcohol spectrum disorder (FASD) occurs when pregnant mothers consume alcohol, causing embryonic ethanol exposure and characteristic birth defects that include craniofacial, neural and cardiac defects.
Swapnalee Sarmah, Pooja Muralidharan, Courtney L. Curtis, Jeanette N. McClintick, Bryce B. Buente, David J. Holdgrafer, Osato Ogbeifun, Opeyemi C. Olorungbounmi, Liliana Patino, Ryan Lucas, Sonya Gilbert, Evan S. Groninger, Julia Arciero, Howard J. Edenberg, James A. Marrs   +14 more
doaj   +1 more source

Embryo-scale tissue mechanics during Drosophila gastrulation movements

Nature Communications, 2015
Morphogenesis of an organism requires the development of its parts to be coordinated in time and space. While past studies concentrated on defined cell populations, a synthetic view of the coordination of these events in a whole organism is needed for a ...
M. Rauzi, U. Kržič, T. Saunders, Matej Krajnc, P. Ziherl, L. Hufnagel, M. Leptin   +6 more
semanticscholar   +1 more source

High concentrations of fluorescent nanoprobes delayed Oryzias melastigma embryo hatching by modulating respiratory and metabolic pathways

VIEW, EarlyView.
We investigated the developmental toxicity of a new graphene‐based fluorescent nanoprobe for tumor cell nucleus (GTTNs) using Oryzias melastigma embryos. The results confirmed that GTTNs have excellent biocompatibility for biomedical applications. Only the highest dose delayed hatching time.
Tianle Tang, Jinyan Chen, Jun Zhang, Pengcheng Pan, Jiahui Jiang, Chenyu Hu, Yuan He, Chenchen Li, Junfeng Zhang, Yanli Wang   +9 more
wiley   +1 more source

Spatial profiling of early primate gastrulation in utero

Nature, 2022
Sophie Bergmann, Christopher A. Penfold, Erin Slatery, D. Siriwardena, C. Drummer, Stephen J. Clark, S. Strawbridge, Keiko Kishimoto, Alice Vickers, Mukul Tewary, Timo N. Kohler, F. Hollfelder, W. Reik, E. Sasaki, R. Behr, Thorsten E. Boroviak   +15 more
semanticscholar   +1 more source

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells

Aging Cell, EarlyView.
Expression of HIRA in embryonic melanoblasts is required for proper epigenetic programing and lineage differentiation. Although HIRA deficiency results in a mild phenotype at birth and young adulthood, the melanocytic lineage is sensitive to proliferative challenge, prone to loss of stem cells and dramatically accelerated hair greying in later life ...
Farah Jaber‐Hijazi, Rouven Arnold, Karthic Swaminathan, Kathryn Gilroy, Alexander T. Wenzel, Anthony Lagnado, Kristina Kirschner, Neil Robertson, Claire Reid, Neil Fullarton, Jeff Pawlikowski, Taranjit Singh Rai, Ian Baranyk, Christina Huan Shi, Kevin Y. Yip, Karen Blyth, Jill P. Mesirov, Melissa L. Harris, João F. Passos, Laura M. Machesky, Peter D. Adams   +20 more
wiley   +1 more source

Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics

British Journal of Pharmacology, EarlyView.
An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama, Carlos G. Vanoye, Paul G. DeCaen   +2 more
wiley   +1 more source

Early human embryonic development: Blastocyst formation to gastrulation.

Developmental Cell, 2022
J. Rossant, P. Tam
semanticscholar   +1 more source

Identification of a Distal Enhancer That Regulates TGF‐β–Induced SNAI1 Expression

Cancer Science, EarlyView.
In TGF‐β–stimulated cells, the activated Smad complex composed of Smad3 and Smad4 associates with the distal super enhancer region 2 (DSE2) and enhances its interaction with the SNAI1 proximal promoter, thus inducing SNAI1 expression. RREB1 regulates the basal activity of the enhancer but not its inducibility by TGF‐β.
Hao Fu, Yuka Itoh, Tomoe Sawaguchi, Shigeo Otake, Chiho Omata, Masao Saitoh, Keiji Miyazawa   +6 more
wiley   +1 more source