Results 51 to 60 of about 50,858 (171)

Phosphoproteomic analysis reveals the diversity of signaling behind ErbB‐inhibitor‐induced phenotypes

The FEBS Journal, EarlyView.
Whole‐organism phosphoproteomics after ErbB inhibitor treatment was assessed in zebrafish embryos. Differential signaling was uncovered after treatments with more selective ErbB inhibitors and pan‐ErbB inhibitors, despite similar neurological and myocardial phenotypes.
Katri Vaparanta, Zejia Song, Iman Farahani, Anne Jokilammi, Johannes Merilahti, Johanna Örling, Noora Virtanen, Pekka Haapaniemi, Cecilia Sahlgren, Klaus Elenius, Ilkka Paatero   +10 more
wiley   +1 more source

Zebrafish as a model for Catel–Manzke syndrome—identification and characterization of the zebrafish TGDS ortholog

The FEBS Journal, EarlyView.
Zebrafish Tgds, when expressed as a recombinant protein, catalyzes the dehydration of UDP‐D‐glucose, the initial step in the formation of 6‐deoxyhexoses. Corresponding Tgds mutations found in Catel–Manzke syndrome patients lead to reduced enzymatic activity and stability.
Maria Rosaria Coppola, Deianira Bellitto, Erfan Asgari, Virginia Bazzurro, Giorgia Casucci, Francesco Piacente, Matteo Bozzo, Davide Ceresa, Costantino Parisi, Cecilia Winata, Simona Candiani, Michela Tonetti   +11 more
wiley   +1 more source

Zebrafish embryonic explants undergo genetically encoded self-assembly

eLife, 2020
Embryonic stem cell cultures are thought to self-organize into embryoid bodies, able to undergo symmetry-breaking, germ layer specification and even morphogenesis.
Alexandra Schauer, Diana Pinheiro, Robert Hauschild, Carl-Philipp Heisenberg   +3 more
doaj   +1 more source

Reproduction and embryonic development of monkeyface prickleback Cebidichthys violaceus in captivity

Journal of Fish Biology, EarlyView.
Abstract Understanding the sequence of embryonic and larval development and the factors necessary to induce reproduction in captivity are critical for developing new species for commercial or conservation aquaculture. In this study, we describe the adult reproductive behaviours and development of eggs, embryos and early larvae of captive monkeyface ...
Kevin D. Hinterman, Matthew R. Hoehn, Luke D. Gardner, Scott L. Hamilton   +3 more
wiley   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

Advanced Science, Volume 12, Issue 41, November 6, 2025.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin, Yang Ruimeng, Wang Peihong, Liu Xiaohui, Yuan Hao, Huang Hongli, Zhou Yongjian, Xie Baoshu   +7 more
wiley   +1 more source

May the force be with you

eLife, 2018
Understanding the coordination of the forces generated in embryos by two processes, convergent extension and convergent thickening, is key to understanding how a hollow sphere of cells develops into an elongated embryo.
Shinuo Weng, John B Wallingford
doaj   +1 more source

Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning

Advanced NanoBiomed Research, Volume 5, Issue 11, November 2025.
Micro‐ and nanotopographical cues, substrate stiffness, and mechanical patterning synergistically direct pluripotent stem cell fate and function by tuning cellular perception at the biointerface. Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential.
Yuan Jiang, Jann Harberts, Yaping Chen, Richard J. Williams, Wei Duan, Rasika M. Samarasinghe, Nicolas H. Voelcker, Roey Elnathan   +7 more
wiley   +1 more source

Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

eLife, 2018
Indirect evidence suggests that blastopore closure during gastrulation of anamniotes, including amphibians such as Xenopus laevis, depends on circumblastoporal convergence forces generated by the marginal zone (MZ), but direct evidence is lacking.
David R Shook, Eric M Kasprowicz, Lance A Davidson, Raymond Keller   +3 more
doaj   +1 more source

Ophthalmologic Findings in an Induced Model of Holoprosencephaly in Zebrafish

Journal of Comparative Neurology, Volume 533, Issue 11, November 2025.
We used a zebrafish (Danio rerio) model to variably induce bmp4 during embryonic development. We show ophthalmologic phenotypes of variable severity depending on the length and onset of bmp4 inductions. We find phenotypes like ocular hypotelorism, synophthalmia, cyclopia, and anophthalmia, which are described to be part of the HPE spectrum.
Johannes Bulk, Valentyn Kyrychenko, Stephan Heermann   +2 more
wiley   +1 more source