Results 61 to 70 of about 50,858 (171)

Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration

eLife, 2018
Pitx2c, a homeodomain transcription factor, is classically known for its left-right patterning role. However, an early wave of pitx2 expression occurs at the onset of gastrulation in several species, indicating a possible earlier role that remains ...
Michelle M Collins, Hans-Martin Maischein, Pascale Dufourcq, Marine Charpentier, Patrick Blader, Didier YR Stainier   +5 more
doaj   +1 more source

Mutations in GFAP Alter Early Lineage Commitment of Organoids

Glia, Volume 73, Issue 11, Page 2167-2188, November 2025.
Main Points Mutations in GFAP alter lineage commitment of organoids. The severity of this commitment defect is dependent on method of embryoid body formation. GFAP is expressed in iPSCs and during early stages of organoid development. . ABSTRACT Glial fibrillary acidic protein (GFAP) is a type‐3 intermediate filament protein mainly expressed in ...
Werner Dykstra, Zuzana Matusova, Rachel A. Battaglia, Pavel Abaffy, Nuria Goya‐Iglesias, Dolores Pérez‐Sala, Henrik Ahlenius, Mikael Kubista, R. Jeroen Pasterkamp, Li Li, Jianfei Chao, Yanhong Shi, Lukas Valihrach, Milos Pekny, Elly M. Hol   +14 more
wiley   +1 more source

The transcription factor Pitx2 positions the embryonic axis and regulates twinning

eLife, 2014
Embryonic polarity of invertebrates, amphibians and fish is specified largely by maternal determinants, which fixes cell fates early in development. In contrast, amniote embryos remain plastic and can form multiple individuals until gastrulation.
Angela Torlopp, Mohsin A F Khan, Nidia M M Oliveira, Ingrid Lekk, Luz Mayela Soto-Jiménez, Alona Sosinsky, Claudio D Stern   +6 more
doaj   +1 more source

The Impact of Maternal Gut Dysbiosis on Embryo/Fetus Development

Cell Proliferation, EarlyView.
Nairui Fan, Yao Shen, Xuesong Yang, Shuxia Ma, Guang Wang   +4 more
wiley   +1 more source

Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells

Cell Proliferation, Volume 58, Issue 11, November 2025.
hESCsdel18q exhibit delayed and impaired anterior neuroectoderm induction, leading to deficient RPE specification. hESCsdel18q lines showed dysregulation of TGFβ signalling, and endogenous overactivation of activin/nodal/TGFβ in hESCsdel18q leads to improper anterior/posterior neuroectodermal fate commitments.
Yingnan Lei, Mai Chi Duong, Nuša Krivec, Charlotte Janssens, Marius Regin, Anfien Huyghebaert, Edouard Couvreu de Deckersberg, Karen Sermon, Diana Al Delbany, Claudia Spits   +9 more
wiley   +1 more source

Egg quality markers in domesticated broodstock of Atlantic halibut (Hippoglossus hippoglossus) with relevance for optimization of hatchery protocols

Frontiers in Aquaculture
IntroductionCommercial production of Atlantic halibut (Hippoglossus hippoglossus) has many obstacles, such as low and highly variable egg quality and survival rates during early developmental stages.
Nils Niepagen, Marc Ferrer Vidal, Leif Berg, Elin Kjørsvik   +3 more
doaj   +1 more source

Rapid Changes in Cholinergic Signaling, Myelination, and Thyroid Signaling Pathway Gene Expression in Amygdala Subnuclei in Response to Social Status Maintenance and Reorganization

European Journal of Neuroscience, Volume 62, Issue 9, November 2025.
ABSTRACT Male CD‐1 mice form linear social hierarchies and can rapidly reform them following social reorganization. Through tag‐based sequencing in the medial amygdala (MeA), we identified several genes regulating cholinergic signaling, myelination, and thyroid signaling that rapidly shift expression 70 min after animals change social status.
Tyler M. Milewski, Won Lee, Köll R. Rada, James P. Curley   +3 more
wiley   +1 more source

Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

eLife, 2019
In mouse embryo gastrulation, epiblast cells delaminate at the primitive streak to form mesoderm and definitive endoderm, through an epithelial-mesenchymal transition.
Bechara Saykali, Navrita Mathiah, Wallis Nahaboo, Marie-Lucie Racu, Latifa Hammou, Matthieu Defrance, Isabelle Migeotte   +6 more
doaj   +1 more source

Discovery of Genetically Distinct, Sympatric Coral Lineages With Temporal but Not Gametic Reproductive Isolation

Molecular Ecology, Volume 34, Issue 22, November 2025.
ABSTRACT Coral species abundance and biodiversity estimates are typically based on colony macromorphology. However, such measurements often underestimate the true diversity within coral communities because morphology does not necessarily reflect behavioral or genetic divergence. We previously reported on the unusual spawning behavior of the brain coral
Valérie F. Chamberland, Matías Gómez‐Corrales, Kristen L. Marhaver, Pim Bongaerts, Kelly R. W. Latijnhouwers, Diana Carolina Vergara‐Flórez, Skylar Snowden, Juan A. Sánchez, Mark J. A. Vermeij   +8 more
wiley   +1 more source

Maternal Torso-Like Coordinates Tissue Folding During Drosophila Gastrulation [PDF]

, 2017
Travis K. Johnson, Karyn A Moore, James C. Whisstock, Coral G. Warr   +3 more
openalex   +1 more source