Results 111 to 120 of about 54,955 (220)

AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes

Clinical &Experimental Allergy, EarlyView.
ABSTRACT The AllergoOncology field brings together the study of allergic and cancer immune responses, having evolved from early epidemiological studies that reported inverse associations between allergies, IgE and cancer risk. Insights from studying allergic inflammation are revealing previously unappreciated immune mechanisms that confer protective ...
Jakub Zydron, Anishaa Balaji, Jitesh Chauhan, Jack Alder, Xinyi Chen, Anna M. F. Wiegman, Aurelie Poli, Joanna Jacków‐Malinowska, Jack Cheeseman, Daniel I. R. Spencer, James McDonnell, James Spicer, Alexandra J. McCraw, Sophia N. Karagiannis   +13 more
wiley   +1 more source

Different Expressions of Specific Transcription Factors of Th1 (T-bet) and Th2 cells (GATA-3) by Peripheral Blood Mononuclear Cells From Patients With Multiple Sclerosis

Basic and Clinical Neuroscience, 2018
Introduction: Multiple Sclerosis (MS) is an inflammatory disorder caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. The Th1 and Th2 cell differentiation are regulated by specific transcription factors, especially T-bet and ...
Zahra Etesam, Maryam Nemati, Mohammad-Amin Ebrahimizadeh, Hossain-Ali Ebrahimi, Hossain Hajghani, Tahereh Khalili, Abdollah Jafarzadeh   +6 more
doaj  

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. [PDF]

, 2019
Fluidity in cell fate or heterogeneity in cell identity is an interesting cell biological phenomenon, which at the same time poses a significant obstacle for cancer therapy.
Doh, Hanna, Kessenbrock, Kai, Roose, Jeroen P, Samocha, Alexandr   +3 more
core   +1 more source

PAX8‐positive conventional urothelial carcinomas of the urinary bladder and their distinct molecular profiles – A clinicopathologic study of 101 consecutive cases with next‐generation sequencing in 20 cases

Histopathology, EarlyView.
PAX8 expression in urothelial carcinoma was investigated in 101 consecutive transurethral resections of the urinary bladder. PAX8 was positive in 10% of cases, with targeted molecular testing of these cases revealing universal TERT promoter mutations and frequent alterations in TSC1, NOTCH1 and WT1. Aims PAX8 immunohistochemistry (IHC) is often used to
Sarah Mae Lammert, Wendy Luo, Allen C Zhu, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta

Scientific Reports, 2017
The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is involved in the synthesis of active steroid hormones. Two human 3β-HSD isoforms are expressed in a tissue-specific pattern.
Tsai-Chun Lai, Hsiao-Fang Li, Yu-Shian Li, Pei-Yu Hung, Ming-Kwang Shyu, Meng-Chun Hu   +5 more
doaj   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]

, 2013
It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren, Seddon, Benedict, Sinclair, Charles, Yates, Andrew J.   +3 more
core   +1 more source

Blue‐Gray Papules on the Chest and Face

JEADV Clinical Practice, EarlyView.
Sanjana Likki, Kevin Lee, Priyadharsini Nagarajan, Doina Ivan, Woo Cheal Cho, Fiorinda Muhaj   +5 more
wiley   +1 more source

Molecular Testing in Sickle Cell Disease: From Newborn Screening to Transfusion Care

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is one of the most frequent monogenic diseases worldwide and a highly heterogeneous and complex disease. SCD care carries several challenges. This includes early and accurate diagnosis as well as optimal red blood cell transfusion matching in this population carrying a high risk of alloimmunization.
Thomas Pincez, Yves D. Pastore
wiley   +1 more source

Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania. [PDF]

, 2017
Mycobacterium tuberculosis (Mtb) and helminth infections elicit antagonistic immune effector functions and are co-endemic in several regions of the world.
A Harari, A Lalvani, A Rougemont, A Sher, AC Mullen, Adam Penn-Nicholson, AK Abbas, Anneth Tumbo, AS McKee, B Speich, Beatrice Nickel, BM Sullivan, C Manca, CB Chesnais, Claudia Daubenberger, CN Ting, CY Chen, D Elias, D Elias, D Elias, D Gebreegziabiher, D Ordway, D Portevin, DA Karagiannis-Voules, Damien Portevin, E Jouanguy, E Jouanguy, E Petruccioli, E Petruccioli, EJ Pearce, EM Lipner, EV Acosta-Rodriguez, F Altare, F Annunziato, F McNab, Fatoumatta Darboe, Francis Mhimbira, G Walzl, GE Kaiko, Giuseppe Pantaleo, H Bruns, Hanspeter Marti, I Malhotra, IR Caldas, J Keane, J Zhu, JA Potian, JE Allen, JK Actor, JL Flynn, JP Huber, JP Huber, JS Sutherland, K Dheda, K Zevallos, KE Wiens, Khalid Ohmiti, KK McKinstry, Klaus Reither, L Barcellini, L Petrone, LB Ivashkiv, LC Osborne, LM Neto, M Brown, M Perreau, M Perreau, M Roederer, Matthieu Perreau, Maxmillian Mpina, MM Van der Zalm, MP Berry, N Caccamo, N van Soelen, ND Marin, P Jayaraman, P Mangtani, P Salgame, Patrizia Amelio, PH Gazzinelli-Guimaraes, PJ Cooper, PJ George, PJ George, PJ Hotez, R Anuradha, R Anuradha, R Anuradha, R de Jong, R Granich, R Tibshirani, RE Callard, RG Jenner, RJ Mazzaccaro, RM Anthony, RM Houben, RM Teles, S Brighenti, S Herbst, S Knopp, S Metenou, S Nookala, S Romagnani, S Romagnani, S Romagnani, SA Stanley, Song Ding, Stefanie Knopp, Subash Babu, T Chiacchio, TA Reese, TA Thomas, TH Ottenhoff, Thomas J. Scriba, U Sester, V Rozot, V Rozot   +115 more
core   +4 more sources