Results 111 to 120 of about 18,813,060 (218)

Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy. [PDF]

, 2019
Solid tumours are infiltrated by effector T cells with the potential to control or reject them, as well as by regulatory T (Treg) cells that restrict the function of effector T cells and thereby promote tumour growth1.
Cadilha, Bruno L, Carrizosa, Esteban, Di Pilato, Mauro, Kim, Edward Y, Ligorio, Matteo, Mani, Vinidhra, Marangoni, Francesco, Medoff, Benjamin D, Mempel, Thorsten R, Misale, Sandra, Nasrallah, Mazen N, Prüßmann, Jasper N, Seruggia, Davide, Usmani, Shariq M, Villani, Alexandra-Chloe, Warner, Ross D, Zappulli, Valentina   +16 more
core   +2 more sources

GATA-3 基因表达质粒的构建及在大鼠脑细胞中的表达

Zhongshan Daxue xuebao. Yixue kexue ban, 2004
【目的】 构建GATA-3基因正义?反义重组质粒,为进一步研究GATA-3在T细胞发育分化中的作用提供基础?【方法】 采用PCR技术扩增GATA-3基因,通过酶切?连接?转化等分子生物学技术,将该全长基因亚克隆至表达载体pCDNA3,构建质粒后转染大肠杆菌,并在大肠杆菌中扩增?同时用脂质体法感染大鼠脑细胞?【结果】 从大鼠脑细胞中成功地克隆出全长1335 bp的GATA-3基因,并经序列分析筛选证实GATA-3基因以正向?反向重组转染入载体,且在大肠杆菌中得到扩增,同时用RT ...
杨培增, 黄祥坤, 纪淑兴
doaj  

Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment [PDF]

, 2016
During T cell development, multipotent progenitors relinquish competence for other fates and commit to the T cell lineage by turning on Bcl11b, which encodes a transcription factor. To clarify lineage commitment mechanisms, we followed developing T cells
A Champhekar, AP Weng, B Varnum-Finney, BN Weber, C Trapnell, CB Franco, CC Tydell, D Avram, D Panne, DD Scripture-Adams, DX Zhang, E Manesso, Ellen V Rothenberg, EV Rothenberg, F Spitz, G Hernández-Hoyos, George Freedman, H Hosokawa, H Wang, Hao Yuan Kueh, HY Kueh, Irwin D Bernstein, J Inoue, JA Zhang, JC Telfer, Jingli A Zhang, K Germar, K Takahashi, Kenneth K H Ng, L Li, L Li, M Ciofani, M Iwafuchi-Doi, M Kawazu, M Mingueneau, M Yu, MA Yui, MA Yui, MA Zarnegar, Mary A Yui, ME De Obaldia, ME García-Ojeda, Michael B Elowitz, MM Del Real, P Li, P Liu, P Liu, S Yu, Sagar S Damle, Sharmayne Siu, Shirley S Pease, T Ikawa, T Naito, T Nakano, T Schroeder, TM Schmitt, TM Schmitt, TN Taghon, W Ebina, Y Guo, Y Wakabayashi, YC Lin   +61 more
core   +3 more sources

Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta

Scientific Reports, 2017
The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is involved in the synthesis of active steroid hormones. Two human 3β-HSD isoforms are expressed in a tissue-specific pattern.
Tsai-Chun Lai, Hsiao-Fang Li, Yu-Shian Li, Pei-Yu Hung, Ming-Kwang Shyu, Meng-Chun Hu   +5 more
doaj   +1 more source

Molecular immunophenotyping of lungs and spleens in naive and vaccinated chickens early after pulmonary avian influenza A (H9N2) virus infection [PDF]

, 2006
In a respiratory-infection-model with the avian influenza A H9N2 virus we studied lung and splenic immune reactions in chickens using a recently developed 5K chicken immuno-microarray.
Burt, Dave W, Degen, Winfried G J, Glass, Elizabeth J, Schijns, Virgil E J C, Simmelink, Bartjan, Smith, Jacqueline   +5 more
core   +1 more source

Different Expressions of Specific Transcription Factors of Th1 (T-bet) and Th2 cells (GATA-3) by Peripheral Blood Mononuclear Cells From Patients With Multiple Sclerosis

Basic and Clinical Neuroscience, 2018
Introduction: Multiple Sclerosis (MS) is an inflammatory disorder caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. The Th1 and Th2 cell differentiation are regulated by specific transcription factors, especially T-bet and ...
Zahra Etesam, Maryam Nemati, Mohammad-Amin Ebrahimizadeh, Hossain-Ali Ebrahimi, Hossain Hajghani, Tahereh Khalili, Abdollah Jafarzadeh   +6 more
doaj  

GATA-3 Dominant Negative Mutant [PDF]

Journal of Biological Chemistry, 1995
Virginia M. Smith, Perry P. Lee, Shannan Szychowski, Astar Winoto   +3 more
openaire   +1 more source

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system [PDF]

, 2013
It has long been recognized that the T-cell compartment has more CD4 helper than CD8 cytotoxic T cells, and this is most evident looking at T-cell development in the thymus.
Bains, Iren, Seddon, Benedict, Sinclair, Charles, Yates, Andrew J.   +3 more
core   +1 more source

Diagnostic utility of GATA3 immunohistochemical expression in urothelial carcinoma

Indian Journal of Pathology and Microbiology, 2019
Aims: This study aims to explore the utility of GATA binding protein 3, a zinc finger transcription factor, expression in genitourinary carcinoma, especially urothelial carcinoma.
Harshita Agarwal, Suresh Babu, Chanchal Rana, Madhu Kumar, Atin Singhai, Shiv Narayan Shankhwar, Vishwajeet Singh, Rahul Janak Sinha   +7 more
doaj   +1 more source

The Expression Levels of Transcription Factors T-bet, GATA-3, RORγt and FOXP3 in Peripheral Blood Lymphocyte (PBL) of Patients with Liver Cancer and their Significance

International Journal of Medical Sciences, 2015
Objectives: To investigate the expression of transcriptional factors (TFs) T-bet, GATA-3, RORγt and FOXP in peripheral blood mononuclear cells (PBMC) of patients with hepatocellular carcinoma (HCC) and to evaluate the correlation between the imbalances ...
Zewei Lin, Li-Xuan Wu, Yong-song Xie, Xi Ou, Peikai Tian, Xiao-ping Liu, Jun Min, Jie Wang, Ru-fu Chen, Yajin Chen, Chao Liu, Hua-shan Ye, Q. Ou   +12 more
semanticscholar   +1 more source