Results 111 to 120 of about 18,250,723 (243)

Different Expressions of Specific Transcription Factors of Th1 (T-bet) and Th2 cells (GATA-3) by Peripheral Blood Mononuclear Cells From Patients With Multiple Sclerosis

Basic and Clinical Neuroscience, 2018
Introduction: Multiple Sclerosis (MS) is an inflammatory disorder caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. The Th1 and Th2 cell differentiation are regulated by specific transcription factors, especially T-bet and ...
Zahra Etesam, Maryam Nemati, Mohammad-Amin Ebrahimizadeh, Hossain-Ali Ebrahimi, Hossain Hajghani, Tahereh Khalili, Abdollah Jafarzadeh   +6 more
doaj  

GATA-3 Promotes Maturation, IFN-γ Production, and Liver-Specific Homing of NK Cells [PDF]

, 2003
The GATA-3 transcription factor has a determinant role in T cell specification and is an essential mediator of T helper 2-type polarized immune responses. While both committed NK precursors and mature NK cells express GATA-3, a role of this transcription
Samson, Sandrine,, Jan Buer, Vosshenrich, CAJ, Thomas Ranson, Buer, Jan, Frank Grosveld, Di Santo, James P, Richard, O, Ranson, Thomas, Vosshenrich, Christian A. J., Tavian, Manuela, Vosshenrich, Christian A.J, Tavian, M, Colucci, F, Godin, I, Odile Richard, Sandrine I Samson, Grosveld, Frank, Francesco Colucci, Manuela Tavian, Di Santo, James, P, James P Di Santo, di Santo, JP, Samson, SI, Buer, J, Samson, Sandrine, I, Christian A.J Vosshenrich, Isabelle Godin, Di Santo, James,, Ranson, T, Colucci, Francesco, Richard, Odile, Samson, Sandrine I, Godin, Isabelle   +33 more
core   +1 more source

Eosinophilia and Hypereosinophilia: A Practical Approach to Navigating a Broad Differential Diagnosis

European Journal of Haematology, EarlyView.
ABSTRACT Eosinophilia, defined as an absolute eosinophil count (AEC) of ≥ 0.5 × 109/L, is a frequently encountered finding with a vast spectrum of potential underlying etiologies. Hypereosinophilia (HE) is defined as AEC > 1.5 × 109/L and may become life‐threatening when eosinophil‐induced organ damage occurs, defining the hypereosinophilic syndrome ...
Stijn Wigerinck, Peter Vandenberghe
wiley   +1 more source

Means and Standard Deviations (SD) for the winning parameters of the TCF-1, GATA-3, BCL11B, and Notch combinations with notation from Table 1: 6d = dimer TCF-1 AND (Notch OR dimer GATA-3); 7b = dimer GATA-3 AND (Notch OR TCF-1); 7d = dimer GATA-3 AND (Notch OR dimer TCF-1); 8b = Notch AND TCF-1 AND dimer GATA-3. The parameters are fully described in S1 File.

, 2016
Means and Standard Deviations (SD) for the winning parameters of the TCF-1, GATA-3, BCL11B, and Notch combinations with notation from Table 1: 6d = dimer TCF-1 AND (Notch OR dimer GATA-3); 7b = dimer GATA-3 AND (Notch OR TCF-1); 7d = dimer GATA-3 AND ...
Erica Manesso (3072768), George Freedman (3072765), Hao Yuan Kueh (52038), Ellen V. Rothenberg (9528), Carsten Peterson (1281)   +4 more
core   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Ocular Manifestations of Infectious Salmon Anaemia Virus Infection in Atlantic Salmon (Salmo salar)

Journal of Fish Diseases, EarlyView.
ABSTRACT Eyes are essential sensory organs needed by teleost Atlantic salmon for high visual acuity and survival in both the wild and in aquaculture settings. In this work, we assessed the ocular manifestations of Infectious Salmon Anaemia Virus (ISAV) infection in Atlantic salmon by a cohabitation‐mediated infection assay and histological and ...
Emily Mahon, Rebecca R. Kwabiah, Hélène Paradis, Manuel A. Soto‐Dávila, Sathees Duglas, Raja Ram Gurung, Thurka Paramanathan, Ignacio Vasquez, Shams Al‐Badoosh, John Law, Javier Santander, Mark D. Fast, Robert L. Gendron   +12 more
wiley   +1 more source

Effects of Acupoint Injection of Autoblood on Expression of Pulmonary Transcription Factor GATA 3 and T-bet Proteins and Genes in Asthma Rats

针刺研究, 2012
Objective To observe the effect of autoblood acupoint-injection(ABAI) on expression levels of pulmonary transacting T-cell-specific transcription factor GATA 3(involving Th 2 cytokine expression),Th 1-specific T-box transcription factor T-box expressed ...
MO Lü, LI Jun-xiong, Julia Kravitz1, TANG Chun-zhi1, GUO Ze-kai2, LI Pei-yong, GUO Feng-mei3   +6 more
doaj  

GATA-3 Dominant Negative Mutant [PDF]

Journal of Biological Chemistry, 1995
Virginia M. Smith, Perry P. Lee, Shannan Szychowski, Astar Winoto   +3 more
openaire   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Notch signaling in the regulation of T-bet and GATA-3 transcription factor mRNA expression in infiltrative pulmonary tuberculosis

Сибирский научный медицинский журнал
The ability of naïve T lymphocytes to differentiate into various effector subpopulations is determined by a complex of receptor-mediated signals from antigen-presenting cells and the cytokine microenvironment.
V. A. Serebryakova, A. E. Sanina, O. I. Urazova   +2 more
doaj   +1 more source