Results 1 to 10 of about 21,925 (161)

Mutational signatures in GATA3 transcription factor and its DNA binding domain that stimulate breast cancer and HDR syndrome [PDF]

Scientific Reports, 2021
Transcription factors (TFs) play important roles in many biochemical processes. Many human genetic disorders have been associated with mutations in the genes encoding these transcription factors, and so those mutations became targets for medications and ...
Atlal El-Assaad, Zaher Dawy, Athar Khalil, Georges Nemer   +3 more
doaj   +5 more sources

Interaction of the pioneer transcription factor GATA3 with nucleosomes [PDF]

Nature Communications, 2020
GATA 3 functions as a pioneer factor during cellular reprogramming. Here the authors delineate nucleosome positioning relative to GATA3 binding motifs and describe the structure of a GATA3–nucleosome complex; providing insight into how a pioneer factor ...
Hiroki Tanaka, Yoshimasa Takizawa, Motoki Takaku, Daiki Kato, Yusuke Kumagawa, Sara A. Grimm, Paul A. Wade, Hitoshi Kurumizaka   +7 more
doaj   +3 more sources

CD4+ T-cell transcription factors as early predictors of phenoconversion in idiopathic rapid eye movement sleep behaviour disorder [version 2; peer review: 2 approved] [PDF]

F1000Research
In this datanote we present data from 31 iRBD (idiopathic Rapid eye movement (REM) sleep Behaviour Disorder) patients followed throughout three years to assess their eventual phenoconversion to Parkinson’s disease and other established neurodegenerative ...
Maurizio Versino, Cristoforo Comi, Franca Marino, Michele Terzaghi, Monica Pinoli, Marco Cosentino   +5 more
doaj   +2 more sources

Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation

Cell Reports
Summary: The TAL1 oncogene driving T cell lymphoblastic leukemia is frequently activated through mutated cis-regulatory elements, whereby small insertions or deletions (indels) create a binding site for the transcription factor MYB.
Joana R. Costa, Yang Li, Nurkaiyisah Zaal Anuar, David O’Connor, Sunniyat Rahman, Tanya Rapoz-D’Silva, Kent T.M. Fung, Rachael Pocock, Zhaodong Li, Stephen Henderson, Lingyi Wang, Mateja E. Krulik, Sara Hyseni, Nivedita Singh, George Morrow, Yanping Guo, Daisy O.F. Gresham, Javier Herrero, Richard G. Jenner, A. Thomas Look, Dennis Kappei, Marc R. Mansour   +21 more
doaj   +3 more sources

Gata3 drives miR-21-5p transcription to mitigate hyperoxia-induced lung injury, independent of CpG Island methylation [PDF]

Scientific Reports
microRNA-21-5p (miR-21-5p) plays a key anti-apoptotic role in hyperoxia-induced lung injury (HALI), but its regulatory mechanisms are not well understood.
Yingcong Ren, Song Qin, Ping Yuan, Qianxia Huang, Ma Huang, Yuanzhi Shi, Miao Chen   +6 more
doaj   +2 more sources

Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear. [PDF]

PLoS ONE, 2009
We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model specific auditory ...
Marta Milo, Daniela Cacciabue-Rivolta, Adam Kneebone, Hikke Van Doorninck, Claire Johnson, Grace Lawoko-Kerali, Mahesan Niranjan, Marcelo Rivolta, Matthew Holley   +8 more
doaj   +7 more sources

ASSOCIATION BETWEEN SPECIFIC FEATURES OF GATA3 TRANSCRIPTION FACTOR EXPRESSION AND LYMPH NODE METASTASIS IN LUMINAL BREAST CANCER

Сибирский онкологический журнал, 2017
Currently, the study of the markers of cell differentiation, proliferative regulators, and molecules involved in the development of drug resistance mechanisms in breast cancer is extremely important. The transcription factor GATA3 plays an essential role
S. V. Vtorushin, D. V. Vasilchenko, К. Y. Khristenko, N. V. Krakhmal, I. V. Stepanov, М. V. Zavyalova, E. M. Slonimskaya, S. V. Patalyak   +7 more
doaj   +3 more sources

Reduced GATA3 expression associates with immuno‐metabolic alterations and aggressive features in breast cancer [PDF]

The Journal of Pathology: Clinical Research
In breast cancer (BC), the transcription factor GATA3 is linked to estrogen receptor (ER) alpha biology, and its loss is associated with aggressive tumor features.
Anna KM Sæle, Amalie A Svanøe, Cecilie Askeland, Gøril Knutsvik, Lise M Ingebriktsen, Rasmus OC Humlevik, Anette Heie, Turid Aas, Ingeborg Winge, Karin Collett, Ingunn M Stefansson, Erling A Hoivik, Lars A Akslen, Elisabeth Wik   +13 more
doaj   +2 more sources

LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3 [PDF]

BMC Biology, 2014
Abnormalities in pyloric development or in contractile function of the pylorus cause reflux of duodenal contents into the stomach and increase the risk of gastric metaplasia and cancer. Abnormalities of the pyloric region are also linked to congenital defects such as the relatively common neonatal hypertrophic pyloric stenosis, and primary ...
Li, Yushan, Pan, Jirong, Wei, Chao, Chen, Juan, Liu, Ying, Liu, Jiali, Zhang, Xiaoxin, Evans, Sylvia M, Cui, Yan, Cui, Sheng   +9 more
openaire   +2 more sources

GATA3 Transcription Factor Abrogates Smad4 Transcription Factor-mediated Fascin Overexpression, Invadopodium Formation, and Breast Cancer Cell Invasion [PDF]

Journal of Biological Chemistry, 2013
Transforming growth factor β (TGFβ) is a potent and context-dependent regulator of tumor progression. TGFβ promotes the lung metastasis of basal-like (but not the luminal-like) breast cancer. Here, we demonstrated that fascin, a pro-metastasis actin bundling protein, was a direct target of the canonical TGFβ-Smad4 signaling pathway in basal-like breast
Jianwei, Sun, Huifang, He, Smitha, Pillai, Yin, Xiong, Sridevi, Challa, Liyan, Xu, Srikumar, Chellappan, Shengyu, Yang   +7 more
openaire   +2 more sources