Continued expression of GATA3 is necessary for cochlear neurosensory development. [PDF]
PLoS ONE, 2013 Hair cells of the developing mammalian inner ear are progressively defined through cell fate restriction. This process culminates in the expression of the bHLH transcription factor Atoh1, which is necessary for differentiation of hair cells, but not for ...
Jeremy S Duncan, Bernd Fritzsch
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Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover [PDF]
BMC Cancer, 2014 The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory program driving tumor growth. GATA3 mutations are frequent in breast cancer and have been classified as driver mutations. To elucidate the contribution(
Adomas, Aleksandra B +5 more
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E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment [PDF]
Blood, 2013 Key Points GATA3 is elevated in E2A−/− DN2 cells. GATA3 contributes to arrested T-cell development from E2A−/− DN2 cells.
Wei, Xu +5 more
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The multi-faceted role of Gata3 in developmental haematopoiesis [PDF]
Open Biology, 2018 The transcription factor Gata3 is crucial for the development of several tissues and cell lineages both during development as well as postnatally. This importance is apparent from the early embryonic lethality following germline Gata3 deletion, with ...
Nada Zaidan, Katrin Ottersbach
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The Transcription Factor GATA3 Actively Represses RUNX3 Protein-Regulated Production of Interferon-γ [PDF]
Immunity, 2010 The transcription factor GATA3 is crucial for the differentiation of naive CD4(+) T cells into T helper 2 (Th2) cells. Here, we show that deletion of Gata3 allowed the appearance of interferon-gamma (IFN-gamma)-producing cells in the absence of interleukin-12 (IL-12) and IFN-gamma.
Yagi, Ryoji +6 more
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Pan-cancer predictions of transcription factors mediating aberrant DNA methylation
Epigenetics & Chromatin, 2022 Background Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcription factors initially thought to be repressed from binding by DNA methylation, have recently ...
Dylane Detilleux +4 more
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GATA3 immunoreactivity expands the transcription factor profile of pituitary neuroendocrine tumors [PDF]
Modern Pathology, 2019 The modern classification of pituitary neuroendocrine tumors relies mainly on immunohistochemistry for pituitary transcription factors, hormones, and other biomarkers, including low molecular weight cytokeratins. The transcription factor GATA2 is required for development of gonadotrophs and thyrotrophs but has not been used for classification of ...
Ozgur Mete +3 more
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Frontiers in Cell and Developmental Biology, 2021 USP21 is a kind of deubiquitinating enzymes involved in the malignant progression of various cancers, while its role in gastric cancer (GC) and the specific molecular mechanism are still unclear.
Qingqu Guo +6 more
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CARMA1 Controls Th2 Cell-Specific Cytokine Expression through Regulating JunB and GATA3 Transcription Factors [PDF]
The Journal of Immunology, 2012 Abstract The scaffold protein CARMA1 is required for the TCR-induced lymphocyte activation. In this study, we show that CARMA1 also plays an essential role in T cell differentiation. We have found that the adoptive transfer of bone marrow cells expressing constitutively active CARMA1 results in lung inflammation, eosinophilia, and ...
Marzenna, Blonska +4 more
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Differential Expression of the Transcription Factor GATA3 Specifies Lineage and Functions of Innate Lymphoid Cells [PDF]
Immunity, 2020 Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs). However, these cells are not derived from the ILC common progenitor, which generates other ILC subsets and is defined by the expression of the transcription factor PLZF.
Chao, Zhong +11 more
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