Results 21 to 30 of about 21,925 (161)

Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs [PDF]

Journal of Clinical Investigation, 2016
The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has pathological consequences. Previous studies have shown that GATA3 function in T cell development is regulated by multiple signaling pathways and that the Notch nuclear effector, RBP-J, binds specifically to the Gata3 promoter ...
Sakie, Ohmura, Seiya, Mizuno, Hisashi, Oishi, Chia-Jui, Ku, Mary, Hermann, Tomonori, Hosoya, Satoru, Takahashi, James Douglas, Engel   +7 more
openaire   +2 more sources

The Gata3 Transcription Factor Is Required for the Survival of Embryonic and Adult Sympathetic Neurons [PDF]

The Journal of Neuroscience, 2010
The transcription factor Gata3 is essential for the development of sympathetic neurons and adrenal chromaffin cells. As Gata3 expression is maintained up to the adult stage, we addressed its function in differentiated sympathoadrenal cells at embryonic and adult stages by conditional Gata3 elimination.
Tsarovina, K., Reiff, T., Stubbusch, J., Kurek, D., Grosveld, F., Parlato, R., Schutz, N., Rohrer, H.   +7 more
openaire   +4 more sources

The Diagnostic Value of Transcription Factors T-bet/GATA3 Ratio in Predicting Antibody-Mediated Rejection [PDF]

Clinical and Developmental Immunology, 2013
Background. Previous data showed that the predominance of intraglomerular T-bet or GATA3 is correlated with different mechanisms of rejection, suggesting that the ratio of T-bet/GATA3 might be used to distinguish antibody-mediated rejection (ABMR) and T-cell-mediated rejection (TCMR).Methods.
Xue Li, Qiquan Sun, Mingchao Zhang, Jinsong Chen, Zhihong Liu   +4 more
openaire   +3 more sources

Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types [PDF]

Immunity, 2011
The transcription factor GATA3 plays an essential role during T cell development and T helper 2 (Th2) cell differentiation. To understand GATA3-mediated gene regulation, we identified genome-wide GATA3 binding sites in ten well-defined developmental and effector T lymphocyte lineages.
Wei, Gang, Abraham, Brian J., Yagi, Ryoji, Jothi, Raja, Cui, Kairong, Sharma, Suveena, Narlikar, Leelavati, Northrup, Daniel L., Tang, Qingsong, Paul, William E., Zhu, Jinfang, Zhao, Keji   +11 more
openaire   +2 more sources

GATA Binding Protein 3 Is a Direct Target of Kruppel-Like Transcription Factor 7 and Inhibits Chicken Adipogenesis

Frontiers in Physiology, 2020
Kruppel-like transcription factor 7 (KLF7) is a negative regulator of adipogenesis, however, its precise mechanism is poorly understood. Our previous KLF7 ChIP-seq analysis showed that one of the KLF7 binding peaks was present upstream of GATA binding ...
Yingning Sun, Yingning Sun, Yingning Sun, Yingning Sun, Zhao Jin, Xinyang Zhang, Xinyang Zhang, Xinyang Zhang, Tingting Cui, Tingting Cui, Tingting Cui, Tingting Cui, Wenjian Zhang, Wenjian Zhang, Wenjian Zhang, Shuli Shao, Hui Li, Hui Li, Hui Li, Ning Wang, Ning Wang, Ning Wang   +21 more
doaj   +1 more source

Gata3 is required in late proneurosensory development for proper sensory cell formation and organization

Scientific Reports, 2023
It has previously been shown that the zinc-finger transcription factor Gata3 has dynamic expression within the inner ear throughout embryonic development and is essential for cochlear neurosensory development. However, the temporal window for which Gata3
Paige V. Blinkiewicz, Makayla R. Long, Zachary A. Stoner, Elizabeth M. Ketchum, Sydney N. Sheltz-Kempf, Jeremy S. Duncan   +5 more
doaj   +1 more source

Expression of FOXP3 and GATA3 Transcription Factors Among Bronchial Asthmatics in Northern Population

Indian Journal of Clinical Biochemistry, 2019
Asthma is a common chronic airways inflammatory disorder in which the expression of genes for the transcription factors FoxP3 and GATA3 plays crucial roles in activation of specific T cells population and pathogenesis of asthma. Recent data have shown that Hb, Eosinophils, total leucocytes count (TLC), absolute eosinophil count (AEC), and IgE, may be ...
Rashmi, Pandey, Ved, Prakash
openaire   +3 more sources

Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear [PDF]

Journal of Comparative Neurology, 2001
AbstractThe transcription factors GATA3 and Pax2 are expressed throughout development of the mouse inner ear. We have used antibodies to study their temporal and spatial expression patterns from embryonic days E8–E16.5. The two factors show reciprocal relationships in the regional patterning of the early otocyst and cellular patterning within the ...
Grace, Lawoko-Kerali, Marcelo N, Rivolta, Matthew, Holley   +2 more
openaire   +2 more sources

Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer

Genome Biology, 2021
Muscle-invasive bladder cancers are characterized by their distinct expression of luminal and basal genes, which could be used to predict key clinical features such as disease progression and overall survival.
Tejaswi Iyyanki, Baozhen Zhang, Qixuan Wang, Ye Hou, Qiushi Jin, Jie Xu, Hongbo Yang, Tingting Liu, Xiaotao Wang, Fan Song, Yu Luan, Hironobu Yamashita, Ruby Chien, Huijue Lyu, Lijun Zhang, Lu Wang, Joshua Warrick, Jay D. Raman, Joshua J. Meeks, David J. DeGraff, Feng Yue   +20 more
doaj   +1 more source

Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues

Cell Reports, 2023
Summary: Lymphoid tissue inducer (LTi) cells, a subset of innate lymphoid cells (ILCs), play an essential role in the formation of secondary lymphoid tissues.
Mingzhu Zheng, Chen Yao, Gang Ren, Kairui Mao, Hyunwoo Chung, Xi Chen, Gangqing Hu, Lei Wang, Xuemei Luan, Difeng Fang, Dan Li, Chao Zhong, Xiaoxiao Lu, Nikki Cannon, Mingxu Zhang, Avinash Bhandoola, Keji Zhao, John J. O’Shea, Jinfang Zhu   +18 more
doaj   +1 more source