Results 31 to 40 of about 21,925 (161)

The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4 [PDF]

Development, 1999
Abstract In this paper, we show that the transcription factor GATA3 is dynamically expressed during hindbrain development. Function of GATA3 in ventral rhombomere (r) 4 is dependent on functional GATA2, which in turn is under the control of Hoxb1.
I, Pata, M, Studer, J H, van Doorninck, J, Briscoe, S, Kuuse, J D, Engel, F, Grosveld, A, Karis   +7 more
openaire   +2 more sources

Transcriptional regulation of FOXP3 requires integrated activation of both promoter and CNS regions in tumor-induced CD8+ Treg cells

Scientific Reports, 2017
T-regulatory cells are an upsurge in the tumor microenvironment and induce immune-evasion. CD4+ Treg cells are well characterized whereas the role of CD8+ Tregs in cancer has recently started to crease attention. Here, we report an augmentation CD8+FOXP3+
Sreeparna Chakraborty, Abir K. Panda, Sayantan Bose, Dia Roy, Kirti Kajal, Deblina Guha, Gaurisankar Sa   +6 more
doaj   +1 more source

Changes in the Expression of Transcription Factors Involved in Modulating the Expression of EPO-R in Activated Human CD4-Positive Lymphocytes. [PDF]

PLoS ONE, 2013
We have recently described the presence of the erythropoietin receptor (EPO-R) on CD4(+) lymphocytes and demonstrated that its expression increases during their activation, reaching a level reported to be typical for erythroid progenitors.
Katarzyna A Lisowska, Joanna E Frackowiak, Anna Mikosik, Jacek M Witkowski   +3 more
doaj   +1 more source

Gata3ZsG and Gata3ZsG-fl: Novel murine Gata3 reporter alleles for identifying and studying Th2 cells and ILC2s in vivo

Frontiers in Immunology, 2022
T helper-2 (Th2) cells and type 2 innate lymphoid cells (ILC2s) play crucial roles during type 2 immune responses; the transcription factor GATA3 is essential for the differentiation and functions of these cell types.
Rama K. Gurram, Danping Wei, Qiao Yu, Qiao Yu, Olena Kamenyeva, Hyunwoo Chung, Mingzhu Zheng, Matthew J. Butcher, Juraj Kabat, Chengyu Liu, Jaspal S. Khillan, Jinfang Zhu   +11 more
doaj   +1 more source

An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation [PDF]

International Immunology, 2011
CD4 T(h) are critical for orchestrating adaptive immune responses. The expression of the transcription factor GATA3 (GATA-binding protein 3) is up-regulated or down-regulated during T(h)2 or T(h)1 cell differentiation, respectively. Furthermore, GATA3 is responsible for induction of T(h)2 differentiation and represses T(h)1 differentiation.
Ryoji, Yagi, Jinfang, Zhu, William E, Paul   +2 more
openaire   +2 more sources

Functional characterization of GATA3 mutations causing the hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome: insight into mechanisms of DNA binding by the GATA3 transcription factor [PDF]

Human Molecular Genetics, 2006
The hypoparathyroidism-deafness-renal (HDR) dysplasia syndrome is an autosomal dominant disorder caused by mutations of the dual zinc finger transcription factor, GATA3. We investigated 21 HDR probands and 14 patients with isolated hypoparathyroidism for GATA3 abnormalities. Thirteen different heterozygous germline mutations were identified in patients
Ali, Asif, Christie, Paul T., Grigorieva, Irina V., Harding, Brian, Van Esch, Hilde, Ahmed, S. Faisal, Bitner-Glindzicz, Maria, Blind, Eberhard, Bloch, Catherine, Christin, Patricia, Clayton, Peter, Gecz, Jozef, Gilbert-Dussardier, Brigitte, Guillen-Navarro, Encarna, Hackett, Anna, Halac, Isil, Hendy, Geoffrey N., Lalloo, Fiona, Mache, Christoph J., Mughal, Zulf, Ong, Albert C M, Rinat, Choni, Shaw, Nicholas, Smithson, Sarah F., Tolmie, John, Weill, Jacques, Nesbit, M. Andrew, Thakker, Rajesh V.   +27 more
openaire   +5 more sources

GATA3 differentially regulates the transcriptome via zinc finger 2-modulated phase separation

Cell Reports
Summary: Phase separation (PS) underlies gene control by transcription factors. However, little is known about whether and how DNA-binding domains (DBDs) regulate the PS for transcription factors to differentially regulate the transcriptome.
Yatao Chen, Yajie Wan, Xiaoying Pei, Ziqi Wei, Tan Wang, Jun Zhang, Liming Chen   +6 more
doaj   +1 more source

Genetic variation of the transcription factor GATA3, not STAT4, is associated with the risk of type 2 diabetes in the Bangladeshi population. [PDF]

PLoS ONE, 2018
Type 2 diabetes mellitus is a multifactorial metabolic disorder caused by environmental factors and has a strong association with hereditary issues. These hereditary issues result in an imbalance in CD4+T cells and a decreased level of naïve CD4+T cells,
Nafiul Huda, Md Ismail Hosen, Tahirah Yasmin, Pankaj Kumar Sarkar, A K M Mahbub Hasan, A H M Nurun Nabi   +5 more
doaj   +1 more source

The Transcription Factor GATA3 Is Essential for the Function of Human Type 2 Innate Lymphoid Cells [PDF]

Immunity, 2012
Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s mediate parasite expulsion but also contribute to airway inflammation, emphasizing the functional similarity between these cells and Th2 cells. Consistent with this, we report that
Mjösberg, Jenny, Bernink, Jochem, Golebski, Korneliusz, Karrich, Julien J., Peters, Charlotte P., Blom, Bianca, te Velde, Anje A., Fokkens, Wytske J., van Drunen, Cornelis M., Spits, Hergen   +9 more
openaire   +2 more sources

CD4+ T-cell transcription factors predict phenoconversion in idiopathic rapid eye movement sleep behavior disorder

Future Science OA
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a ...
Monica Pinoli, Michele Terzaghi, Franca Marino, Cristoforo Comi, Maurizio Versino, Marco Cosentino   +5 more
doaj   +1 more source