Results 41 to 50 of about 495,118 (275)

ELISPOTs Produced by CD8 and CD4 Cells Follow Log Normal Size Distribution Permitting Objective Counting

Cells, 2015
Each positive well in ELISPOT assays contains spots of variable sizes that can range from tens of micrometers up to a millimeter in diameter. Therefore, when it comes to counting these spots the decision on setting the lower and the upper spot size ...
Alexey Y. Karulin, Kinga Karacsony, Wenji Zhang, Oleg S. Targoni, Ioana Moldovan, Marcus Dittrich, Srividya Sundararaman, Paul V. Lehmann   +7 more
doaj   +1 more source

Gating-by-tilt of mechanosensitive membrane channels

, 2003
We propose an alternative mechanism for the gating of biological membrane channels in response to membrane tension that involves a change in the slope of the membrane near the channel. Under biological membrane tensions we show that the energy difference
A. Kloda, A. N. J. A. Ridder, B. Alberts, B. Calabrese, B. Martinac, I. V. Tabarean, J. Gullingsrud, J. M. Wood, M. Goulian, Matthew S. Turner, O. P. Hamill, Pierre Sens, R. S. Cantor, S. A. Safran, S. I. Sukharev, S. I. Sukharev   +15 more
core   +1 more source

The Role of Working Memory Gating in Task Switching: A Procedural Version of the Reference-Back Paradigm

Frontiers in Psychology, 2017
Models of working memory (WM) suggest that the contents of WM are separated from perceptual input by a gate, that enables shielding information against interference when closed, and allows for rapid updating when open.
Yoav Kessler
doaj   +1 more source

Feto-Maternal Crosstalk in the Development of the Circadian Clock System

Frontiers in Neuroscience, 2021
The circadian (24 h) clock system adapts physiology and behavior to daily recurring changes in the environment. Compared to the extensive knowledge assembled over the last decades on the circadian system in adults, its regulation and function during ...
Mariana Astiz, Henrik Oster
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Effects of repetitive practice of motor tasks on somatosensory gating

Frontiers in Human Neuroscience, 2023
IntroductionDuring voluntary muscle contraction, the amplitude of the somatosensory evoked potential (SEP) is reduced by inhibiting sensory information from a peripheral nerve supplying the contracted muscle.
Mayu Akaiwa, Yuya Matsuda, Hidekazu Saito, Eriko Shibata, Takeshi Sasaki, Kazuhiro Sugawara   +5 more
doaj   +1 more source

Ambipolar transport in bulk crystals of a topological insulator by gating with ionic liquid

, 2012
We report that the ionic-liquid gating of bulk single crystals of a topological insulator can control the type of the surface carriers and even results in ambipolar transport. This was made possible by the use of a highly bulk-insulating BiSbTeSe2 system
J. Ye, Kouji Segawa, Satoshi Sasaki, Susumu Kuwabata, Tetsuya Tsuda, Yoichi Ando, Zhi Ren   +6 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Molecular and Evolution In Silico Studies Unlock the h4-HPPD C-Terminal Tail Gating Mechanism

Biomedicines
The enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) is involved in the catabolism of the amino acid tyrosine in organisms such as bacteria, plants, and animals.
Alfonso Trezza, Ancuta Birgauan, Michela Geminiani, Anna Visibelli, Annalisa Santucci   +4 more
doaj   +1 more source

Aquaporins: More Than Functional Monomers in a Tetrameric Arrangement

Cells, 2018
Aquaporins (AQPs) function as tetrameric structures in which each monomer has its own permeable pathway. The combination of structural biology, molecular dynamics simulations, and experimental approaches has contributed to improve our knowledge of how ...
Marcelo Ozu, Luciano Galizia, Cynthia Acuña, Gabriela Amodeo   +3 more
doaj   +1 more source