Results 61 to 70 of about 495,118 (275)

Monte Carlo study of gating and selection in potassium channels

open access: yes, 2011
The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles.
A. L. Hodgkin   +6 more
core   +1 more source

The Historical Development of Easter-Southern Freight Rate Relationships [PDF]

open access: yes, 1947
A method for creating and presenting video-recorded synchronized audiovisual stimuli at a high frame rate-which would be highly useful for psychophysical studies on, for example, just-noticeable differences and gating-is presented.
Potter, David M.
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

The Role of Proton Transport in Gating Current in a Voltage Gated Ion Channel, as Shown by Quantum Calculations

open access: yesSensors, 2018
Over two-thirds of a century ago, Hodgkin and Huxley proposed the existence of voltage gated ion channels (VGICs) to carry Na+ and K+ ions across the cell membrane to create the nerve impulse, in response to depolarization of the membrane.
Alisher M. Kariev, Michael E. Green
doaj   +1 more source

Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

open access: yeseLife, 2021
Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating electrochemical signaling in neurons and other excitable cells.
Cathrine Bergh   +3 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Replicase-Mediated Resistance to Cucumber Mosaic Virus Does Not Inhibit Localization and/or Trafficking of the Viral Movement Protein

open access: yesMolecular Plant-Microbe Interactions, 1999
Replicase-mediated resistance to cucumber mosaic virus (CMV) affects CMV replication and restricts CMV movement. Confocal laser scanning microscopic analysis of resistant plants inoculated with either CMV or potato virus X, expressing the CMV movement ...
Tomas Canto, Peter Palukaitis
doaj   +1 more source

The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

open access: yeseLife, 2021
NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on a resolved cryo-EM structure, we performed all-atom molecular dynamics simulations and electrophysiological experiments to ...
Yang Wang   +7 more
doaj   +1 more source

Increasing efficiency of switching type regulator circuits Patent [PDF]

open access: yes, 1968
Switching series regulator with gating control ...
Clapp, W. M.
core   +1 more source

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