Results 91 to 100 of about 8,559 (195)
Domain II of the translation elongation factor eEF1A is required for Gcn2 kinase inhibition
, 2020 The signalling pathway governing general control nonderepressible (Gcn)2 kinase allows cells to cope with amino acid shortage. Under starvation, Gcn2 phosphorylates the translation initiation factor eukaryotic translation initiation factor (eIF)2 alpha ...
Evelyn Sattlegger +3 more
core +1 more source
mTORC1 senses glutamine and other amino acids through GCN2
The EMBO JournalmTORC1 promotes cell growth when nutrients such as amino acids are available. While dedicated sensors relaying availability of leucine, arginine and methionine to mTORC1 have been identified, it is still unclear how mTORC1 senses glutamine, one of its ...
Gianluca Figlia +6 more
doaj +1 more source
, 2018 SENSING DES ACIDES AMINÉSSENSING DES ACIDES AMINÉSLe sensing par GCN2 : la souris CARE-LUC, un outil pour visualiser l’activation de la voie GCN2-eIF2a-ATF4.
Bruhat, Alain
core +1 more source
The GCN2 kinase activates early events of autophagy
, 2018 Autophagy Session : Selected oral communication, Poster N°37 Organizing Committee: Chairs: Didier Attaix, Lydie Combaret and Daniel TaillandierAutophagy Session : Selected oral communication, Poster N°37Organizing Committee: Chairs: Didier Attaix, Lydie ...
B'Chir, Wafa +10 more
core +2 more sources
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
JCI InsightAcute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from both B and T cell lineages (B-ALL and T-ALL). Current therapy exploits ALL cells’ low expression of asparagine synthetase (ASNS) by using L-asparaginase, a bacterial ...
Rodney Claude +17 more
doaj +1 more source
General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases
Frontiers in AgingThe function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals.
Ozlem Altintas +2 more
doaj +1 more source
The amino acid sensor GCN2 biases macronutrient selection during aging
, 2011 International audiencePurpose Selection of a balanced diet has a determinant impact on human health. Individual food preferences involve socio-cultural as well as physiological factors and evolve during aging.
Cédric Chaveroux +21 more
core +1 more source
Molecular OncologyNutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance.
Marie Piecyk +21 more
doaj +1 more source
Absence of GCN2 favor HIV-1 protein expression.
, 2012 (A, B) HeLa cells were co-transfected with plasmids encoding wild type GCN2 or the inactive mutant GCN2-K618R and also with a mixture of HIV-1 encoding plasmids pNL4-3.Luc.R-E- and pNL4-3.GFP.R-E-. Cells were harvested 24 h after transfection.
Javier del Pino (125161) +6 more
core +1 more source