Results 111 to 120 of about 8,559 (195)

Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions

Diverse environmental insults induce the integrated stress response (ISR), which features eIF2 phosphorylation and translational control that serves to restore protein homeostasis. The eIF2 kinase GCN2 is a first responder in the ISR that is activated by
Misra, Jagannath, Carlson, Kenneth R., Spandau, Dan F., Wek, Ronald C.   +3 more
core   +1 more source

Kinase GCN2 and the phosphorylation of HIV-1 integrase

, 2014
L’intégrase (IN) du VIH-1 est une enzyme clé qui catalyse l’insertion stable du génome viral dans celui de la celluleinfectée. D’autre part, l’IN participe également à de nombreuses étapes du cycle viral telles que la transcriptioninverse ou la ...
Jaspart, Anaïs
core  

Elevated GCN2 levels in cancer cells confer protection from mitotic stress and faster cell movement. [PDF]

Cell Oncol (Dordr)
Stonyte V, Fjeldbo CS, Langiu M, Joy-Immediato M, Swaminathan P, Humagain PS, Valencia-Pesqueira LM, Lindbergsengen L, Campsteijn C, Lyng H, Grallert B.   +10 more
europepmc   +1 more source

Redox-metabolic circuits as a central regulator of T cell-based immunotherapy. [PDF]

Front Immunol
McPhedran S, Zhao T, Lum JJ.
europepmc   +1 more source

Fungistatic effect of sorbic acid on yeast cells via translational repression involving eIF2 α phosphorylation and formation of Ded1- and eIF2B-granules. [PDF]

Microb Cell
Yoshiyama H, Nomura W, Izawa S.
europepmc   +1 more source

An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity. [PDF]

J Biol Chem
Misra J, Spandau DF, Vilseck JZ, Anthony TG, Staschke KA, Wek RC.   +5 more
europepmc   +1 more source

Extracellular vesicles derived by hypoxic preconditioned EPCs attenuated atherosclerosis by suppressing ferroptosis via regulating arginine metabolism. [PDF]

Redox Biol
Luo X, Zhu X, Chen Y, Guo Y, Xu B, Mou J, Wang M, Gu Q, Sun Q, Lv Y, Huang X, Zeng M, Yi B, Liu X, Bai X, Fang C, Li J, Yu B, Jia H.   +18 more
europepmc   +1 more source

Amino acid insufficiency orchestrates AMPK and mTOR signaling. [PDF]

Fundam Res
Li T, Zhao L, Jia D.
europepmc   +1 more source

A Novel Potent and Selective GCN2 Inhibitor, APL-4098, Has Antileukemic Activity through Dysregulation of Mitochondrial Function. [PDF]

Clin Cancer Res
Román-Trufero M, Whitlock G, Seydoux C, Blighe K, Perfler B, Zebisch A, Butt R, Fuchter MJ, Auner HW, Clemo N.   +9 more
europepmc   +1 more source

Regulatory dynamics of monosomes and polysomes in cellular adaptation. [PDF]

J Biochem
Imai H, Yamashita A.
europepmc   +1 more source