Results 101 to 110 of about 8,559 (195)
mBioThe fungus Cryptococcus neoformans is an opportunistic pathogen of humans that reprograms its translatome to facilitate adaptation and virulence within the host.
David Goich +4 more
doaj +1 more source
GCN2 in Viral Defence and the Subversive Tactics Employed by Viruses
Journal of Molecular BiologyThe recent SARS-CoV-2 pandemic and associated COVID19 disease illustrates the important role of viral defence mechanisms in ensuring survival and recovery of the host or patient. Viruses absolutely depend on the host's protein synthesis machinery to replicate, meaning that impeding translation is a powerful way to counteract viruses. One major approach
Victoria J. Gibbs +8 more
openaire +2 more sources
GCN2 adapts protein synthesis to scavenging-dependent growth
Pancreatic cancer cells with limited access to free amino acids can grow by scavenging extracellular protein. In a murine model of pancreatic cancer, we performed a genome-wide CRISPR screen for genes required for scavenging-dependent growth.
Wang, Tim +12 more
core +1 more source
, 2013 Asparaginase is an important drug in the treatment regimen for acute lymphoblastic leukemia. Asparaginase depletes circulating asparagine and glutamine, activating an amino acid stress response (AAR) involving phosphorylation of eukaryotic initiation ...
Anthony, Tracy G. +4 more
core +1 more source
GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
Cell ReportsSummary: Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity.
Alexandros P. Drainas +9 more
doaj +1 more source
GCN2 enhances p21 translation independently of p53.
, 2015 A) qPCR for p21 was performed on RNA isolated from wildtype, p53-/-, p63-/-, and p73-/- MEFs deprived of leucine for the indicated times. p21 transcript levels were normalized to 18S rRNA.
Gregg J. Johannes (759146) +5 more
core +1 more source
Interleukin-6 is critical in the development of pulmonary vascular disease in Gcn2-deficient mice.
Biallelic mutations in EIF2AK4, encoding Eukaryotic Translation Initiation Factor 2α kinase 4 or General Control Nonderepressible 2 (GCN2), cause pulmonary veno-occlusive disease (PVOD), a fatal form of pulmonary hypertension. The mechanisms linking GCN2
core +2 more sources
Uncharged tRNA Activates GCN2 by Displacing the Protein Kinase Moiety from a Bipartite tRNA-Binding Domain [PDF]
, 2000 Protein kinase GCN2 regulates translation in amino acid–starved cells by phosphorylating eIF2. GCN2 contains a regulatory domain related to histidyl-tRNA synthetase (HisRS) postulated to bind multiple deacylated tRNAs as a general sensor of starvation ...
Hinnebusch, Alan G. +4 more
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Protéine kinase GCN2 et phosphorylation de l’intégrase du VIH-1
, 2014 HIV-1 integrase (IN) catalyzes the integration of the viral DNA into the cellular genome. Besides, IN is also involved inother steps of the viral life cycle like the reverse transcription or the viral maturation.
Jaspart, Anaïs
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