mBioThe fungus Cryptococcus neoformans is an opportunistic pathogen of humans that reprograms its translatome to facilitate adaptation and virulence within the host.
David Goich +4 more
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GCN2 in Viral Defence and the Subversive Tactics Employed by Viruses
Journal of Molecular BiologyThe recent SARS-CoV-2 pandemic and associated COVID19 disease illustrates the important role of viral defence mechanisms in ensuring survival and recovery of the host or patient. Viruses absolutely depend on the host's protein synthesis machinery to replicate, meaning that impeding translation is a powerful way to counteract viruses. One major approach
Victoria J. Gibbs +8 more
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GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
Cell ReportsSummary: Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption of the G1 checkpoint in SCLC cells creates a dependency on the G2/M checkpoint to maintain genomic integrity.
Alexandros P. Drainas +9 more
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Novel cancer-related roles of GCN2
, 2020 GCN2, an amino-acid deprivation sensor is one of the kinases activated during the integrated stress response. Its role in normal as well as in cancer cells during stress induced by starvation has garnered a lot of attention. Most of the literature describes GCN2’s role based on its action on the eIF2-ATF4 pathway.
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A genetic approach to identify amino acids in human GCN1 required for mediating Gcn2 activation. [PDF]
MicroPubl BiolGhuge A +3 more
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The integrated stress response kinase GCN2 prevents ZAKα-Dependent inflammatory hyperactivation in macrophages. [PDF]
J Biol ChemRequião RD +12 more
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Beyond Translation Initiation: Translational Elongation, Decoding Fidelity, and Ribosome Surveillance During Branched-Chain Amino Acid Deprivation, with a Focus on Mammalian Systems. [PDF]
Biology (Basel)Ojima M, Matsuura M, Deguchi M, Kim DH.
europepmc +1 more source
From Cellular Stress to Systemic Adaptation: The Circadian Clock and Stress Response at Cellular and Systemic Levels. [PDF]
Int J Mol SciIvankovic I, Ramavath HN, Cao RR.
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Interleukin-6 is critical in the development of pulmonary vascular disease in <i>Gcn2-</i>deficient mice. [PDF]
Proc Natl Acad Sci U S ASchwiening M +12 more
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