Results 81 to 90 of about 8,559 (195)
Biology Direct, 2017 The protein Gcn1 (General control non-derepressible 1) is found in virtually all eukaryotes, and is a key component of the general amino acid control signal transduction pathway.
Ramachandran Rakesh +3 more
doaj +1 more source
PLoS Genetics, 2020 Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters, as constituents in proteins and as nutrients. GCN2-mediated phosphorylation of eukaryotic initiation factor 2 alpha (elF2α) restores homeostasis in ...
Hiromi Yamazaki +14 more
doaj +1 more source
Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance
MedComm, Volume 7, Issue 8, August 2026.The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar +12 more
wiley +1 more source
DataSheet_1_Involvement of the eIF2α Kinase GCN2 in UV-B Responses.pdf
, 2019 GCN2 (general control nonrepressed 2) is a serine/threonine-protein kinase that regulates translation in response to stressors such as amino acid and purin deprivation, cold shock, wounding, cadmium, and UV-C exposure. Activated GCN2 phosphorylates the α-
Isabel Faus (8055008) +6 more
core +1 more source
Hypothalamic eIF2α Signaling Regulates Food Intake
Cell Reports, 2014 The reversible phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) is a highly conserved signal implicated in the cellular adaptation to numerous stresses such as the one caused by amino acid limitation.
Anne-Catherine Maurin +15 more
doaj +1 more source
HIV-1 protease directly cleaves GCN2.
, 2012 (A) BHK-21 cells were transfected by electroporation with in vitro transcribed capped Sindbis virus RNAs from plasmids pT7SV-HIV-1PR (C+HIV-1Pro), pT7SV-2Apro (C+2APro), pT7SVwt (C) for the expression of HIV-1 and PV-2A proteases.
Javier del Pino (125161) +6 more
core +1 more source
HIV-1 cleavage inhibits GCN2 eIF2alpha kinase activity.
, 2012 (A) Affinity purified human GCN2 was incubated for 30 min at 30°C in the absence or the presence of HIV-1Pro and in the absence or the presence of 2.5 µM SQ, as indicated, prior to being assayed in an eIF2alpha kinase assay (lanes 1–5). In lane 6, SQ was
Javier del Pino (125161) +6 more
core +1 more source
GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension
JCI InsightPulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure.
Maggie M. Zhu +4 more
doaj +1 more source
HF-mediated activation of autophagy is dependent on GCN2.
, 2018 (A) Immunoblot analysis of LC3 protein (LC3II conversion, membrane-bound form) in lysates of WT or GCN2−/−MEFs left untreated or treated with HF at concentrations specified for 6 h. β-actin was used as loading control.
Sumbul Afroz (5066183) +13 more
core +1 more source
An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
Life Science AllianceGCN2 restrains ribosome biogenesis at mRNA and translational levels, keeps protein synthesis in check, and maintains metabolic homeostasis independently of the ISR in a subset of cancers. The integrated stress response (ISR) is a corrective physiological
Mónica Román-Trufero +18 more
doaj +1 more source