Results 61 to 70 of about 7,295 (170)

Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis [PDF]

BMC Plant Biology, 2015
The increased selection pressure of the herbicide glyphosate has played a role in the evolution of glyphosate-resistance in weedy species, an issue that is becoming a threat to global agriculture. The molecular components involved in the cellular toxicity response to this herbicide at the expression level are still unidentified.In this study, we ...
Faus, Isabel, Zabalza Aznárez, Ana, Santiago, Julia, Nebauer, Sergio G., Royuela Hernando, Mercedes, Serrano, Ramón, Gadea, José   +6 more
openaire   +6 more sources

The appropriate dietary methionine content reduces deamination and gluconeogenesis in Chinese perch (Siniperca chuatsi)

Journal of the World Aquaculture Society, Volume 57, Issue 5, October 2026.
Abstract This study evaluated the effects of different dietary methionine (Met) levels on the feeding, growth, and protein metabolism of Chinese perch, Siniperca chuatsi. Six diets containing graded levels of Met (0.88%, 1.11%, 1.68%, 2.02%, 2.27%, and 2.72%) were fed to fish (initial weight: 13.74 ± 0.12 g) for 8 weeks.
Xinyao Ji, Jiacheng Hu, Baoye Hao, Jinguo Chen, Binhua Niu, Yufei Zhang, Xu‐Fang Liang, Liwei Liu   +7 more
wiley   +1 more source

Targeted Modulation of Eukaryotic Release Factor 1 (OseRF1) by an RNA Aptamer Enhances Drought Adaptation in Rice

Plant Biotechnology Journal, Volume 24, Issue 10, Page 5440-5459, October 2026.
ABSTRACT Drought stress severely restricts rice productivity, necessitating strategies to enhance stress resilience. Here, we identify translation termination as a tunable regulatory node for stress adaptation. Using 25 rounds of SELEX, we isolated RTAR, an RNA aptamer that binds the rice eukaryotic release factor 1 (OseRF1) with nanomolar affinity ...
Shuangfeng Dai, Mingming Chen, Haomin Chen, Yuantao Ye, Hong Huang, Renrong Zhang, Zhenyu Guo, Yongxiang Huang   +7 more
wiley   +1 more source

The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells

eLife, 2019
The eukaryotic translation initiation factor 2α (eIF2α) kinase GCN2 is activated by amino acid starvation to elicit a rectifying physiological program known as the Integrated Stress Response (ISR).
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron   +6 more
doaj   +1 more source

Aging concomitantly reduces skeletal muscle proteome plasticity and hypertrophic responses to resistance training in male adults

Physiological Reports, Volume 14, Issue 19, October 2026.
We examined the vastus lateralis (VL) muscle proteomic signature in younger and older males before and after a 10–12‐week resistance training period. Despite similar training volumes between age groups, VL hypertrophy (determined via ultrasound) was dampened in older individuals, and this coincided with an attenuated proteome plasticity response.
Dustyn T. Lewis, J. Max Michel, Mason C. McIntosh, Dakota R. Tiede, Daniel L. Plotkin, Madison L. Mattingly, Nicholas J. Kontos, George Kontos Jr., Breanna J. Mueller, Samuel C. Norton, Joshua S. Godwin, Brad J. Schoenfeld, Melissa D. Boersma, Andrew D. Frugé, C. Brooks Mobley, Andreas N. Kavazis, Michael D. Roberts   +16 more
wiley   +1 more source

Downhill running regulates cardiac immune response through GCN2.

PLoS ONE
Downhill running (DR) has recently emerged as a promising exercise modality for cardiac rehabilitation, but the effect and mechanism of DR on myocardium remains unclear. General control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α (eIF2α)
Xinyue Bai, Wanting Zhang, Yingyue Zhang, Xin Xu   +3 more
doaj   +1 more source

The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.

PLoS ONE, 2019
IMPACT, a highly conserved protein, is an inhibitor of the eIF2α kinase GCN2. In mammals, it is preferentially expressed in neurons. Knock-down of IMPACT expression in neuronal cells increases basal GCN2 activation and eIF2α phosphorylation and decreases
Catia M Pereira, Renato Filev, Francisco P Dubiela, Bruna B Brandão, Claudio M Queiroz, Raissa G Ludwig, Debora Hipolide, Beatriz M Longo, Luiz E Mello, Marcelo A Mori, Beatriz A Castilho   +10 more
doaj   +1 more source

GCN2 regulates paclitaxel‐induced neuropathic pain

British Journal of Pharmacology
Background and Purpose Neuropathic pain is debilitating and pervasive. Chemotherapeutic agents commonly induce chronic neuropathic pain. Paclitaxel is a prototypical example, causing painful peripheral neuropathy in a majority of patients.
Mikesell, Alexander R., Meyer, Angela R., García, Guadalupe, Frietze, Luke R., Stucky, Cheryl L., Pan, Tao, Campbell, Zachary T.   +6 more
openaire   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, Volume 16, Issue 9, Page 1766-1785, September 2026.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.

PLoS Genetics, 2020
Amino acids exert many biological functions, serving as allosteric regulators and neurotransmitters, as constituents in proteins and as nutrients. GCN2-mediated phosphorylation of eukaryotic initiation factor 2 alpha (elF2α) restores homeostasis in ...
Hiromi Yamazaki, Shuya Kasai, Junsei Mimura, Peng Ye, Atsushi Inose-Maruyama, Kunikazu Tanji, Koichi Wakabayashi, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Tsubasa Sato, Taku Ozaki, Douglas R Cavener, Masayuki Yamamoto, Ken Itoh   +14 more
doaj   +1 more source