Results 61 to 70 of about 6,913 (153)

Hypothalamic eIF2α Signaling Regulates Food Intake

Cell Reports, 2014
The reversible phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) is a highly conserved signal implicated in the cellular adaptation to numerous stresses such as the one caused by amino acid limitation.
Anne-Catherine Maurin, Alexandre Benani, Anne Lorsignol, Xavier Brenachot, Laurent Parry, Valérie Carraro, Christophe Guissard, Julien Averous, Céline Jousse, Alain Bruhat, Cédric Chaveroux, Wafa B’chir, Yuki Muranishi, David Ron, Luc Pénicaud, Pierre Fafournoux   +15 more
doaj   +1 more source

GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arterial hypertension

JCI Insight
Pulmonary arterial hypertension (PAH) is characterized by progressive increase of pulmonary vascular resistance and remodeling that result in right heart failure.
Maggie M. Zhu, Jingbo Dai, Zhiyu Dai, Yi Peng, You-Yang Zhao   +4 more
doaj   +1 more source

An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation

Life Science Alliance
GCN2 restrains ribosome biogenesis at mRNA and translational levels, keeps protein synthesis in check, and maintains metabolic homeostasis independently of the ISR in a subset of cancers. The integrated stress response (ISR) is a corrective physiological
Mónica Román-Trufero, Istvan T Kleijn, Kevin Blighe, Jinglin Zhou, Paula Saavedra-García, Abigail Gaffar, Marilena Christoforou, Axel Bellotti, Joel Abrahams, Abdelmadjid Atrih, Douglas Lamont, Marek Gierlinski, Pooja Jayaprakash, Audrey M Michel, Eric O Aboagye, Mariia Yuneva, Glenn R Masson, Vahid Shahrezaei, Holger W Auner   +18 more
doaj   +1 more source

mTORC1 senses glutamine and other amino acids through GCN2

The EMBO Journal
mTORC1 promotes cell growth when nutrients such as amino acids are available. While dedicated sensors relaying availability of leucine, arginine and methionine to mTORC1 have been identified, it is still unclear how mTORC1 senses glutamine, one of its ...
Gianluca Figlia, Sandra Müller, Fabiola Garcia-Cortizo, Marilena Neff, Glynis Klinke, Gernot Poschet, Aurelio A Teleman   +6 more
doaj   +1 more source

General control nonderepressible 2 (GCN2) as a therapeutic target in age-related diseases

Frontiers in Aging
The function of General Control Nonderepressible 2 (GCN2), an evolutionary-conserved component of the integrated stress response (ISR), has been well-documented across organisms from yeast to mammals.
Ozlem Altintas, Michael R. MacArthur, Michael R. MacArthur   +2 more
doaj   +1 more source

Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2

Cell Reports, 2016
FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction to FGF21 induction.
Thomas Laeger, Diana C. Albarado, Susan J. Burke, Lexus Trosclair, John W. Hedgepeth, Hans-Rudolf Berthoud, Thomas W. Gettys, J. Jason Collier, Heike Münzberg, Christopher D. Morrison   +9 more
doaj   +1 more source

The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context

Molecular Oncology
Nutrient availability is a key determinant of tumor cell behavior. While nutrient‐rich conditions favor proliferation and tumor growth, scarcity, and particularly glutamine starvation, promotes cell dedifferentiation and chemoresistance.
Marie Piecyk, Mouna Triki, Pierre‐Alexandre Laval, Cedric Duret, Joelle Fauvre, Laura Cussonneau, Christelle Machon, Jerôme Guitton, Nicolas Rama, Benjamin Gibert, Gabriel Ichim, Frederic Catez, Fleur Bourdelais, Sebastien Durand, Jean‐Jacques Diaz, Isabelle Coste, Toufic Renno, Serge N. Manié, Nicolas Aznar, Stephane Ansieau, Carole Ferraro‐Peyret, Cedric Chaveroux   +21 more
doaj   +1 more source

A GCN1-independent activator of the kinase GCN2

Abstract Mutations of EIF2AK4, which encodes the eIF2α kinase GCN2, cause a severe inherited form of pulmonary hypertension called pulmonary veno-occlusive disease (PVOD). Some pathogenic variants of GCN2 are amenable to pharmacological reactivation by low concentrations of ATP-pocket binding inhibitors.
Giulia Emanuelli, JiaYi Zhu, Glenn R Masson, Vanesa Vinciauskaite, Henriette Willems, Andrew Lim, Christopher Alan Brown, David Winpenny, Murray Clarke, Rebecca Gilley, Fergus Preston, Jordan Wilson, Aldo Bader, Taufiq Rahman, Joseph E Chambers, John Skidmore, Nicholas W Morrell, Stefan J Marciniak   +17 more
openaire   +1 more source

GCN2 in Viral Defence and the Subversive Tactics Employed by Viruses

Journal of Molecular Biology
The recent SARS-CoV-2 pandemic and associated COVID19 disease illustrates the important role of viral defence mechanisms in ensuring survival and recovery of the host or patient. Viruses absolutely depend on the host's protein synthesis machinery to replicate, meaning that impeding translation is a powerful way to counteract viruses. One major approach
Victoria J. Gibbs, Yu H. Lin, Aditi A. Ghuge, Reuben A. Anderson, Anja H. Schiemann, Layla Conaglen, Bianca J.M. Sansom, Richard C. da Silva, Evelyn Sattlegger   +8 more
openaire   +2 more sources

Gcn2 rescues reprogramming in the absence of Hog1/p38 signaling in C. neoformans during thermal stress

mBio
The fungus Cryptococcus neoformans is an opportunistic pathogen of humans that reprograms its translatome to facilitate adaptation and virulence within the host.
David Goich, Amanda L. M. Bloom, Sean R. Duffy, Maritza N. Ventura, John C. Panepinto   +4 more
doaj   +1 more source